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Researchers find new genetic influences on alcohol metabolism

Deitrich. "They found candidate genes for variations in alcohol metabolism that have never been suggested to have anything to do with alcohol metabolism, especially the superoxide dismutase enzyme. The implications are that it becomes increasingly important to do these kind of studies since they are continually turning up genes that apparently influence alcohol metabolism and alcohol's effects that we would never have considered as being important previously."

"Our job now is to home in on the specific genes," said Crabbe. "This requires making specific crosses between mouse strains and testing the offspring until we gradually get closer and closer to the actual genes involved. As these studies progress, we should be able to locate the relevant genes in humans as well, because knowing where the genes are in mice tells us where to look in humans. Potentially, finding additional genetic participants in alcohol metabolism could serve as sources of treatments in the future."


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15-May-2002


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