HOME >> BIOLOGY >> NEWS
Researchers find new mechanism for growing new blood vessels

BOSTON--Researchers have identified a potentially powerful tool to promote the growth of new blood vessels in the heart to replace blocked ones. The discovery may lead to a new treatment for people with coronary artery disease or peripheral vascular disease. It also links for the first time two biological processes - inflammation and hypoxia - that normally trigger some new blood vessel growth in the body

Cardiologist Michael Simons, MD, director of the Angiogenesis Research Center at Beth Israel Deaconess Medical Center, and his colleagues have found that a naturally occurring antibacterial peptide called PR39 encourages angiogenesis. In mice studies, injecting PR39 into the myocardium resulted in a three-fold increase in vessel growth, according to a paper published in the Jan. 2000 issue of Nature Medicine. Most importantly, says Simons, the newly formed vessels were fully functional.

PR39 achieves this affect by a new mechanism. The peptide blocks the degradation of a "master switch" transcription factor. Known as hypoxia-inducible factor (HIF)-1alpha, it turns on expression of multiple angiogenesis-related genes, including genes for the growth factor VEGF and its receptors. Also, PR39 stimulates the expression of receptors for another family of potent inducers of angiogenesis, fibroblast growth factors (FGF). A combination of VEGF and FGF has been shown to be much more effective in inducing angiogenesis than either group alone, says Simons, also an associate professor of medicine at Harvard Medical School.

The peptide PR39 promotes angiogenesis by blocking the cell's central protein-degradation factory known as a proteasome, an organized collection of cellular proteases, which would otherwise break down HIF-1alpha. "Unlike the other available proteasome inhibitors, PR39 appears to be fairly selective for HIF-1alpha, thereby likely minimizing side effects typically observed with the use of proteasome inhibitors," says Simons. "This unique mechani
'"/>

Contact: Carol Cruzan Morton
cmorton@caregroup.harvard.edu
617-975-6150
Beth Israel Deaconess Medical Center
4-Jan-2000


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to lead ... near term focus on Type 2 diabetes and associated comorbidities. , Justin brings ... areas and classes. As Chief Commercial Officer, Justin will lead Better Therapeutics’ ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues in ... FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/cellandgenetherapy ... most effective way to complete one? Will the study comply with all FDA ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... (MBS) has announced a publication detailing the use of its revolutionary NEXTGENPCR ... chain reaction (RT-PCR) in 16 minutes. The article, titled "Ultra-fast one-step RT-PCR ...
Breaking Biology News(10 mins):
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... develop a vaccine or drug treatment. In an effort to better understand the ... released the world’s largest imaging dataset portraying therapeutic compound effects from over 1,600 ...
(Date:6/28/2020)... ... June 26, 2020 , ... The Security Industry ... its strong opposition to the recently introduced bicameral Facial Recognition and Biometric ... most federal use of nearly all biometric and related image analytics technologies, incorrectly ...
(Date:6/23/2020)... ... 2020 , ... DeCurtis Corporation, the premier provider of location ... has been appointed CEO and President. Founder and former CEO, David DeCurtis, will ... Corporation has been on an incredible journey for the last twenty years, and ...
Breaking Biology Technology:
Cached News: