Researchers first to catalogue interactions of an organism's proteins

In recent years, researchers have made significant scientific advancements by decoding the entire genetic blueprint the genome of several organisms, including humans. That work, however, is only a first step in understanding how living things are put together and how they operate.

Now, a team of scientists at North Carolina State University has played a key role in the first analysis of the function of all of an organism's important proteins, the main building blocks of all living organisms. That peer-reviewed research, headed by a team of scientists from Yale University, is described in the July 27 edition of the journal Science.

Proteins are the complex molecules created to carry out the instructions in an organism's genes, encoded in DNA, for how that organism grows and functions. Research on how those proteins work, called "proteomics," is an emerging field of scientific study.

The Yale-NC State proteomics project analyzed how 5,800 proteins in yeast interact with each other, with DNA and with lipids, the molecules that make up the membranes surrounding cells.

"This project is very exciting because up to now we haven't been able to look at how the proteins interact for an entire organism," said Dr. Ralph A. Dean, NC State professor of plant pathology. "We're now able to tell what the important proteins of an organism do."

Dean directs the Fungal Genomics Laboratory at NC State, which helped create the process that makes it possible to quickly analyze an organism's "proteome," or roster of proteins. That procedure separates individual yeast proteins and prepares each for analysis on matchbook-sized "proteome chips." Fungal Genomics Lab scientists also organized the vast amount of data that went into analyzing 93.5 percent of yeast's 6,200 proteins, and assisted in the data analysis.

Dean said this new "high-throughput" procedure, which took only six months to develop for the yeast proteome, could be used to pre

Contact: Dr. Ralph Dean
North Carolina State University

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