HOME >> BIOLOGY >> NEWS
Researchers identify 170 genes involved in Crohn's disease and ulcerative colitis

Genetic Fingerprint May Lead to Better Diagnoses and Treatments

Researchers have developed the first genetic profile for Crohn's disease and ulcerative colitis, two types of inflammatory bowel diseases (IBD). The feat, reported in the March issue of Human Molecular Genetics, is a key step toward understanding and defining new treatments for IBD, which afflicts millions of Americans.

"Before this study, only a few genes involved in these diseases were known, but that list has been significantly expanded to 170 genes," says Shukti Chakravarti, Ph.D., an assistant professor of medicine at Johns Hopkins University School of Medicine. "Some of the identified genes may be involved in primary events, directly causing disease, whereas others are likely important in determining the course of disease. For instance, some of these genes play a role in the wounding and healing process, secondary events that lead to tissue damage and fibrosis."

In addition to paving the way for better therapies, Chakravarti, lead investigator of the study, says that the genetic "fingerprints" should also help physicians more specifically diagnose patients who remain in the vague category of having "some type of indeterminate bowel disease." The two diseases share many similar characteristics and thus are sometimes hard to differentiate, but they clearly have very different genetic profiles.

Applying DNA microarray technology, the most powerful method for gene expression profiling, Chakravarti analyzed colon tissue from six individuals who had Crohn's disease (CD), 12 with ulcerative colitis (UC), and six unaffected controls. The scientists screened 7,306 human genes, searching for ones that were activated or repressed in patients, and identified 29 genes uniquely altered in expression in Crohn's disease, 108 in ulcerative colitis, and 33 additional genes involved in both conditions.

Many of the genes identified were not previously recognized
'"/>

Contact: Kate O'Rourke
korourke@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
7-Mar-2001


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/7/2017)... , March 7, 2017 Brandwatch , the leading ... The Prince,s Trust to uncover insights to support its ... Trust. The UK,s leading youth charity will be using ... results and get a better understanding of the topics and issues ... ...
(Date:3/6/2017)... Calif. , March 6, 2017 ... and sales technology, today announced Predictive Sales Coach ... for infusing actionable sales intelligence into Salesforce. This ... automatically enable their sales organizations with deep knowledge ... that allow for intelligent engagement. Predictive Sales Coach ...
(Date:3/2/2017)... , March 2, 2017 Summary ... to better understand Merck KGaA and its partnering interests ... https://www.reportbuyer.com/product/3605601/ Description The Partnering Deals and ... the partnering activity of one of the world,s leading ... are prepared upon purchase to ensure inclusion of the ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... Calif. (PRWEB) , ... March 21, 2017 , ... ... on Kickstarter , more than tripling its goal and raising over $30,000 in ... vertical garden that grows nutritious veggies & herbs fast, easy, and affordably, anywhere. ...
(Date:3/22/2017)... ... March 21, 2017 , ... ... its innovative Quantum peristaltic pump with patented ReNu single-use (SU) cartridge technology. ... standard for high-pressure feed pumps in SU tangential flow filtration (TFF), virus ...
(Date:3/22/2017)... ... ... The Society for Immunotherapy of Cancer (SITC) strongly opposes the proposed budget ... year 2018 budget request. , This proposal calls for a reduction ... 20% of its total budget. If applied proportionally across NIH, funding for the National ...
(Date:3/22/2017)... N.J. and PETACH TIKVAH, Israel ... Inc. (NASDAQ: BCLI), a leading developer of adult stem ... Chaim Lebovits , Chief Executive Officer, will provide an ... Sachs Associates 2 nd Annual Neuroscience Biopartnering and ... at the New York Academy of Sciences. ...
Breaking Biology Technology:
Cached News: