HOME >> BIOLOGY >> NEWS
Researchers identify 170 genes involved in Crohn's disease and ulcerative colitis

Genetic Fingerprint May Lead to Better Diagnoses and Treatments

Researchers have developed the first genetic profile for Crohn's disease and ulcerative colitis, two types of inflammatory bowel diseases (IBD). The feat, reported in the March issue of Human Molecular Genetics, is a key step toward understanding and defining new treatments for IBD, which afflicts millions of Americans.

"Before this study, only a few genes involved in these diseases were known, but that list has been significantly expanded to 170 genes," says Shukti Chakravarti, Ph.D., an assistant professor of medicine at Johns Hopkins University School of Medicine. "Some of the identified genes may be involved in primary events, directly causing disease, whereas others are likely important in determining the course of disease. For instance, some of these genes play a role in the wounding and healing process, secondary events that lead to tissue damage and fibrosis."

In addition to paving the way for better therapies, Chakravarti, lead investigator of the study, says that the genetic "fingerprints" should also help physicians more specifically diagnose patients who remain in the vague category of having "some type of indeterminate bowel disease." The two diseases share many similar characteristics and thus are sometimes hard to differentiate, but they clearly have very different genetic profiles.

Applying DNA microarray technology, the most powerful method for gene expression profiling, Chakravarti analyzed colon tissue from six individuals who had Crohn's disease (CD), 12 with ulcerative colitis (UC), and six unaffected controls. The scientists screened 7,306 human genes, searching for ones that were activated or repressed in patients, and identified 29 genes uniquely altered in expression in Crohn's disease, 108 in ulcerative colitis, and 33 additional genes involved in both conditions.

Many of the genes identified were not previously recognized
'"/>

Contact: Kate O'Rourke
korourke@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
7-Mar-2001


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... -- The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative high ... ... Maldives Immigration Controller ... (small picture on the right) have received the IAIR award for the ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/22/2017)... , March 21, 2017   Neurotechnology ... object recognition technologies, today announced the release of ... (SDK), which provides improved facial recognition using up ... on a single computer. The new version uses ... improve accuracy, and it utilizes a Graphing Processing ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... ... flow controllers based on capillary thermal mass flow technology provide exponentially more accurate ... applications. Over 80% of all industrial processes—such as those involving chemical reactions, ...
(Date:4/27/2017)... ... April 27, 2017 , ... Volunteers supported by ... engineers, and industry professionals in visiting U.S. Congressional offices in Washington, D.C., yesterday ... world photonics industry. , This year, National Photonics Initiative (NPI) Congressional ...
(Date:4/27/2017)...  Pendant Biosciences, Inc. (formerly Nanoferix, Inc.), a privately-held ... delivery technologies, today announced that it has been accepted ... Toronto . Shawn Glinter , ... "We are excited to become part of the JLABS ... honored to be the first Tennessee ...
(Date:4/26/2017)... ... April 26, 2017 , ... Looking ... team-building and cooking events company, offers one-of-a-kind gifts, ranging from gourmet cooking experiences ... California cuisine, and guests leave inspired with new cooking tips and techniques, thanks ...
Breaking Biology Technology:
Cached News: