HOME >> BIOLOGY >> NEWS
Researchers identify cell, genetic environment behind nerve-tissue tumors that lead to cancer

DALLAS May 3, 2002 Researchers at UT Southwestern Medical Center at Dallas believe they are hot on the trail of a way to prevent benign tumors that attack the nervous system and can be precursors to terminal cancer.

The research, published in todays edition of Science, reveals that tumors in neurofibromatosis 1 (NF-1) patients form out of a particular type of cell, the Schwann cell. Neurofibromatosis, also known as von Recklinghausen disease, is a genetic disorder that causes benign tumors to form on the nerves, skin and internal organs.

Neurofibromatosis is the most common neurological disorder caused by a single gene, and there are two distinct forms: NF-1, which affects multiple organ systems, including the central and peripheral nervous systems, and is present in about 1 in 3,500 people worldwide; and NF-2, which affects only the vestibular nerve, a cranial nerve related to hearing and balance, and the membranes around the brain and spinal cord. NF-2 is present in about 1 in 40,000 people worldwide.

The benign tumors, called neurofibromas, develop into malignant tumors, called neurofibrosarcomas, in 10 percent to 15 percent of NF-1 patients. The malignant tumors do not respond well to currently available treatments.

The new research describes genetically permissive and restrictive environments for NF-1 tumor development. The tumors grow in a permissive environment, but they are nonexistent when the environment is restrictive, researchers say.

Dr. Yuan Zhu, instructor in the Center for Developmental Biology and lead author of the study, said the findings could lead to a new approach to combating NF-1. Zhu has been studying neurofibromatosis since 1995, when as a graduate student he joined the lab of Dr. Luis Parada, director of the Center for Developmental Biology and senior author of the paper.

The focus has always been on attacking the tumor cells, Zhu said. But in our findings, killing the tumor cells is not t
'"/>

Contact: Wayne Carter
Wayne.Carter@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
2-May-2002


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... RATON, Florida , March 31, 2016 ... LEGX ) ("LegacyXChange" or the "Company") ... for potential users of its soon to be launched ... video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide ... the use of DNA technology to an industry that ...
Breaking Biology News(10 mins):
(Date:4/28/2016)... -- The report "Cryocooler Market by Type ... Support, Product Repairs & Refurbishment, Preventive Maintenance, and Customer ... published by MarketsandMarkets, the global market is expected to ... CAGR of 7.29% between 2016 and 2022. ... spread through 159 Pages and in-depth TOC on  "Cryocooler ...
(Date:4/28/2016)... ... April 28, 2016 , ... Connecticut Innovations (CI), ... today announced the launch of VentureClash , a $5 million global investment ... “VentureClash looks to attract the best early-stage companies here in Connecticut, around the ...
(Date:4/28/2016)... ... 28, 2016 , ... As part of an ongoing global ... expanding its LATAM network and logistics capabilities. Enhancements have been made to ... trial projects. , The expansion will provide unmatched clinical trial logistics services for ...
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... Cambridge ... by semantic web technology, today announced that it has been named to The Silicon ... sciences, financial services and other markets, Cambridge Semantics serves the needs of end users ...
Breaking Biology Technology:
Cached News: