HOME >> BIOLOGY >> NEWS
Researchers identify distinctive signature for metastatic prostate cancer

Howard Hughes Medical Institute researchers have identified a telltale change in cellular machinery that could help clinicians predict whether prostate cancers are likely to spread or remain relatively harmless in the prostate.

The researchers found that a cellular signaling molecule called Hedgehog, which drives normal development and regeneration of prostate tissue, is greatly activated in prostate cancers. This elevated activity distinguishes dangerous metastatic cancers those that are likely to spread from those that remain benign and localized to the prostate.

Prostate cancer is the second leading cause of cancer death in men, and an estimated 230,000 cases will be diagnosed this year, according to the American Cancer Society. Treatment for prostate cancer can cause significant side effects, including sexual and urinary dysfunction, yet may not be needed for men whose cancers are unlikely to spread.

The researchers' findings were published September 12, 2004, in an advance online publication in the journal Nature. The scientists were led by Howard Hughes Medical Institute (HHMI) investigator Philip A. Beachy and his colleagues at The Johns Hopkins University School of Medicine, Drs. David Berman and Sunil Karhadkar. Additional coauthors included other colleagues at Johns Hopkins and a researcher from the U.S. Department of Agriculture.

"These findings quite unexpectedly extend understanding of the Hedgehog pathway to a role in prostate cancer, which is a major form of cancer," commented molecular oncologist Charles Sawyers, an HHMI investigator at the Jonsson Comprehensive Cancer Center at UCLA. "The results are incredibly interesting, because they are among the most promising I've seen to enable distinguishing good-risk cancers from bad-risk cancers and thus, those that need minimal therapy from those that are lethal."

The Hedgehog signaling pathway is a well-known regulator of organ development. Beachy and his colleague
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
13-Sep-2004


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers report new gene test for isolated cleft lip and palate
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/26/2019)... , ... October 24, 2019 , ... World Cord Blood ... parents, doctors, nurses, and midwives to learn about the current and future uses of ... Cord blood is now being used to treat and cure over 80 different life-threatening ...
(Date:10/26/2019)... ... October 25, 2019 , ... The ... in La Plata, MD. Orofacial myofunctional disorders (OMDs) are abnormal movement patterns of ... speaks. This can include anything from difficulty swallowing and limited tongue movement to ...
(Date:10/22/2019)... ... October 22, 2019 , ... Greenberg Traurig, LLP’s global ... Deal Making in the Life Sciences Sector,” with German biotech strategy consulting firm, Catenion. ... at Greenberg Traurig’s Tokyo office . , Speakers from Greenberg Traurig and Catenion ...
Breaking Biology News(10 mins):
(Date:11/6/2019)... , ... November 06, 2019 , ... ... through off-the-record collaboration and dialogue, today announces its East/West CEO conference ... in San Francisco. , Kicking off the week of the J.P. ...
(Date:11/5/2019)... , ... November 05, 2019 , ... ... announced it has received CE Mark for its Fusion Bx 2.0 prostate fusion ... and user-friendly interface, the Fusion Bx 2.0 will give urologists across Europe the ...
(Date:11/2/2019)... TORONTO (PRWEB) , ... October 31, 2019 , ... ... are not always used to communicating with each other: study managers, principal investigators, ... cause misunderstandings if a party is not informed of the latest data, potentially ...
(Date:11/2/2019)... ... October 31, 2019 , ... drug360 graph, ... pioneer tellic. drug360 brings tellic’s expertise in biomedical language processing and machine ... quickly uncover relationships between genes, diseases, variants, phenotypes, and other biomedical entities. ...
Breaking Biology Technology:
Cached News: