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Researchers identify enzyme essential for battle against bacteria in the intestine

leased away from the connective tissue and toward surfaces where bacteria are first encountered."

A number of drug companies are developing inhibitors for MMPs for treatment of cancer and arthritis, with the idea that these drugs will block the ability of cells to metastasize or to erode cartilage in the leg. But these broad-acting compounds would inhibit matrilysin as well. Therefore, Parks thinks the companies should try a different approach. "An important thing about this work is that it tells drug companies that you might not want to inhibit this enzyme. Apparently, it's a good guy," Parks said. "For example, in arthritis you want to target the metalloproteinase that's causing a problem and leave matrilysin alone."

This research was funded by grants from the Barnes-Jewish Hospital Foundation and the National Institutes of Health.

Wilson CL, Ouellette AJ, Satchell DP, Tokiyoshi A, Yolanda SL, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC. Regulation of Intestinal a-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense. Science, 286, 113--17, Oct. 1, 1999.


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Contact: Diane Duke Williams
duke@medicine.wustl.edu
314-286-0111
Washington University School of Medicine
1-Oct-1999


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