HOME >> BIOLOGY >> NEWS
Researchers identify enzyme that turns on RNA

MADISON - Knowing an organism's genome is good, but knowing what turns on its genes is even better.

Scientists have long searched for triggers that activate ribonucleic acid (RNA), a key component in gene expression. Now, in the Thursday, Sept. 19 issue of the journal Nature, scientists from the University of Wisconsin-Madison report that they have found an enzyme that activates RNA, which could lead to new ways of regulating genetic information.

"One of the big questions in molecular biology is how genes are controlled," says Judith Kimble, a Howard Hughes Medical Institute investigator, a UW-Madison professor of biochemistry and senior author of the paper. "Our finding provides an important piece of the puzzle."

Inside the nucleus of every cell are genes, which are composed of deoxyribonucleic acid (DNA). This genetic information contains all the instructions cells need to make proteins, molecules that enable cells to carry out special functions, such as the transport of oxygen by red blood cells. For these cellular activities to happen, DNA must get copied into RNA, which carry the instructions outside the nucleus to the molecular machinery that makes proteins.

But along the way, things can go awry: If an RNA isn't activated, Kimble says, "it can get trashed or hidden away. And, if the cell doesn't have a particular RNA, it won't have any of the protein the RNA encodes."

Liaoteng Wang, lead author of the article and a graduate student in Kimble's lab, adds, "a gene won't do any good if it fails to be expressed."

By studying the embryonic development of the microscopic worm, C. elegans, Kimble and Wang, as well as Marvin Wickens and Christian Eckmann also from UW-Madison's biochemistry department, identified two proteins - GLD-2 and GLD-3 - that, when bound together to form an enzyme, activate specific RNAs outside the nucleus. This activation would enable the RNA to carry out important steps of germ line, or rep
'"/>

Contact: Judith Kimble
jekimble@facstaff.wisc.edu
608-262-6188
University of Wisconsin-Madison
18-Sep-2002


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: