Researchers identify gene that controls formation of heart chambers

DALLAS April 1, 2002 Scientists at UT Southwestern Medical Center at Dallas and their colleagues at UT Austin have identified a gene that controls formation of the hearts ventricles a finding that may eventually lead to preventing some of the most lethal heart defects in American children.

We found that the gene named Bop is the primary controller in a cascade of genetic events that include activating another gene, Hand2, that we previously found to be fundamental to the formation of the right ventricle and proper development of the left ventricle, said Dr. Deepak Srivastava, associate professor of pediatrics and molecular biology at UT Southwestern.

Dr. Paul D. Gottlieb, professor of molecular genetics and microbiology at UT Austin and a principal investigator on the study, said, We had previously discovered that Bop was in the mouse immune systems T cells, or bone marrow white cells, and in adult heart and skeletal muscle cells. But it wasnt clear what its function was. Now we know that Bop encodes a protein instrumental in controlling the early steps of embryonic cells differentiating into mature cardiac muscle cells.

Srivastava, senior author of the study and holder of the Joel B. Steinberg, M.D., Chair in Pediatrics at UT Southwestern, said, We have taken a critical step along the ongoing path to developing preventives for heart defects affecting nearly one out of 100 American children.

The study, to be posted April 1 on the Nature Genetics Web site and published in the journals May 1 issue, reports that deleting Bop in mouse embryos consistently disrupted maturation of heart-muscle cells and stymied formation of the right ventricle.

The findings should be applicable to humans, Srivastava said, because genetic parallels can be found in heart development among all animal species, including the fruit fly.

Thats the beauty of the heart: Its at the core of survival and the pressures for survival. Hence the genetic

Contact: Worth Wren Jr.
UT Southwestern Medical Center

Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:6/23/2020)... ... June 23, 2020 , ... ... gene-to-protein and monoclonal antibody development services, today announced that the company has ... services to the pharmaceutical, diagnostics, and research industries. The decision to pursue ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around ... the use of mass spectrometry in this field has gained a lot of momentum ... choose which approach to use (LBA or MS)?” In many cases, either technology ...
(Date:6/23/2020)... ... , ... In its June 22 online post, business and technology news platform ... Ph.D., founder and director of stem cell biotechnology company Asymmetrex . Superb Crew ... starting July 5 it would begin offering free tissue stem cell counting ...
Breaking Biology News(10 mins):
(Date:7/7/2020)... ... 2020 , ... Bio-IT World has announced the winners of ... University of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were ... outstanding examples of how technology innovations and strategic initiatives can be powerful forces ...
(Date:7/1/2020)... ... June 30, 2020 , ... Flagship ... of a new clinical diagnostics immuno-oncology service, TissueInsight . TissueInsight provides ... “Flagship’s TissueInsight is a service that aids pathologists, oncologists, and immunologists in ...
(Date:6/28/2020)... ... June 25, 2020 , ... Lumeda Inc. ... cancer, today announced the company has entered a license agreement with Roswell Park ... Lumeda globally exclusive rights to Roswell Park intellectual property surrounding a novel medical ...
(Date:6/23/2020)... Fla. (PRWEB) , ... June 23, 2020 , ... ... enabled solutions in complex indoor environments, announced today that Derek Fournier has been ... role of Chairman of the Board, effective immediately. , “DeCurtis Corporation has ...
Breaking Biology Technology:
Cached News: