HOME >> BIOLOGY >> NEWS
Researchers identify genes associated with aging of the retina

ANN ARBOR University of Michigan Kellogg Eye Center researchers have found that the aging of the human retina is accompanied by distinct changes in gene expression.

Using commercially available DNA slides, a team of researchers directed by Anand Swaroop, Ph.D., have established the first-ever gene profile of the aging human retina, an important step in understanding the mechanisms of aging and its impact on vision disorders.

In the August issue of Investigative Ophthalmology and Visual Science, Swaroop and colleagues show that retinal aging is associated, in particular, with expression changes of genes involved in stress response and energy metabolism.

The term gene expression means that in any given cell, only a portion of the genes are expressed or switched on. For example, a person's pancreas and retina have the same genes, but only the pancreas can turn on the genes that allow it to make insulin.

Swaroop believes that the findings will help scientists understand whether age predisposes one to changes in the retina that, in turn, lead to age-related diseases. For vision researchers, one of the most pressing disorders is age-related macular degeneration (AMD), a progressive eye disease that affects the retina and results in the loss of one's fine central vision.

"While we still don't know what causes AMD, we do know that the strongest factors are age and family history," says. Swaroop. "We are likely to find that AMD is caused by a complex interaction between genetic and environmental risk factors."

Microarray technology is an important tool for gene profiling because it allows rapid comparison of thousands of genes, something that was unheard of even few years ago. Shigeo Yoshida, M.D., Ph.D., a post-doctoral research fellow in Swaroop's laboratory, examined microarray slides containing DNA from 2,400 human genes.

After identifying the genes expressed in the retina (about half, or 1,200 genes), the res
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
26-Jun-2002


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/17/2016)... 2016  AIC announces that it has just released a new white paper authored ... scale-out plus high speed data transfer storage solutions. Photo - http://photos.prnewswire.com/prnh/20161116/440463 ... ... ... Setting up a high performance computing or HPC system ...
(Date:11/15/2016)... Research and Markets has announced the addition ... report to their offering. ... The global ... from USD 6.21 Billion in 2016, growing at a CAGR of ... bioinformatics market is driven by the growing demand for nucleic acid ...
(Date:6/27/2016)... , June 27, 2016 Research and ... North America 2016-2020" report to their offering. ... North America to grow at a CAGR of ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... ... 2016 , ... Lajollacooks4u, San Diego’s premier team building events and cooking events ... program offerings and company expansion. , This is largely due to its ... over 30 people. Ever since, Lajollacooks4u has seen significant demand for its services from ...
(Date:12/8/2016)... ... December 08, 2016 , ... From wearable devices that can ... sports. On Thursday, December 15th a panel of entrepreneurs, innovators and a Philadelphia ... at a Smart Talk session. Smart Talk will run from 8:30 – 10:30 ...
(Date:12/8/2016)... SAN DIEGO , Dec. 8, 2016 /PRNewswire/ ... presented demonstrating the role of the Breast Cancer ... stage, ER+ breast cancer are most at-risk for ... therapy. Data include results from three studies advancing ... provide information related to tumor biology and inform ...
(Date:12/8/2016)... Dec. 8, 2016 Eurofins announces the appointment of ... of Eurofins Scientific Inc. (ESI). Mr. Murray will ... professional and entrepreneurial experience in leading international business teams. As the ... testing market to uphold Eurofins, status as the global leader in ... , ...
Breaking Biology Technology:
Cached News: