HOME >> BIOLOGY >> NEWS
Researchers identify genes associated with aging of the retina

ANN ARBOR University of Michigan Kellogg Eye Center researchers have found that the aging of the human retina is accompanied by distinct changes in gene expression.

Using commercially available DNA slides, a team of researchers directed by Anand Swaroop, Ph.D., have established the first-ever gene profile of the aging human retina, an important step in understanding the mechanisms of aging and its impact on vision disorders.

In the August issue of Investigative Ophthalmology and Visual Science, Swaroop and colleagues show that retinal aging is associated, in particular, with expression changes of genes involved in stress response and energy metabolism.

The term gene expression means that in any given cell, only a portion of the genes are expressed or switched on. For example, a person's pancreas and retina have the same genes, but only the pancreas can turn on the genes that allow it to make insulin.

Swaroop believes that the findings will help scientists understand whether age predisposes one to changes in the retina that, in turn, lead to age-related diseases. For vision researchers, one of the most pressing disorders is age-related macular degeneration (AMD), a progressive eye disease that affects the retina and results in the loss of one's fine central vision.

"While we still don't know what causes AMD, we do know that the strongest factors are age and family history," says. Swaroop. "We are likely to find that AMD is caused by a complex interaction between genetic and environmental risk factors."

Microarray technology is an important tool for gene profiling because it allows rapid comparison of thousands of genes, something that was unheard of even few years ago. Shigeo Yoshida, M.D., Ph.D., a post-doctoral research fellow in Swaroop's laboratory, examined microarray slides containing DNA from 2,400 human genes.

After identifying the genes expressed in the retina (about half, or 1,200 genes), the res
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
26-Jun-2002


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... MELBOURNE, Australia , March 2, 2017 ... Therapeutics Ltd (ASX: CYP), has signed an agreement ... researchers from the Monash Biomedicine Discovery Institute and Department ... , to conduct a further preclinical study to support ... the treatment of asthma.  Asthma is ...
(Date:2/28/2017)... , February 28, 2017 News solutions ... ... Amsterdam from 14 to 16 March, Materna will ... and show how seamless travel is a real benefit for passengers. ... added biometrics to their passenger touch point solutions to take passengers ...
(Date:2/26/2017)... , Feb. 25, 2017  Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... Recidivism and Reentry. "Too often, too ... prisons and county jails are trying to tackle ... inmates and friends and family members. While significant steps ...
Breaking Biology News(10 mins):
(Date:3/24/2017)... -- On Thursday, March 23, 2017, the ... 0.07%; the Dow Jones Industrial Average edged 0.02% lower, ... at 2,345.96, marginally dropping 0.11%. US markets saw a ... sectors finished in red, and 1 sector ended flat ... coverage on the following Biotechnology equities: BioDelivery Sciences International ...
(Date:3/23/2017)... , Mar 23, 2017 Research ... Products: Global Markets" report to their offering. ... The Global ... $466.6 Billion in 2016 at a CAGR of 8.9%, ... energetic and non-energetic bioproducts into seven major product segments: bio-derived ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... recently selected by the Connecticut Technology Council (CTC) as a 2017 Women of ... thirteenth annual Women of Innovation Awards Dinner. , The dinner recognizes women accomplished ...
(Date:3/23/2017)... In today,s pre-market research, Stock-Callers.com ... Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), Eyegate Pharmaceuticals ... and Regulus Therapeutics Inc. (NASDAQ: RGLS ). ... its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." Learn more ... ...
Breaking Biology Technology:
Cached News: