HOME >> BIOLOGY >> NEWS
Researchers identify genes associated with aging of the retina

ANN ARBOR University of Michigan Kellogg Eye Center researchers have found that the aging of the human retina is accompanied by distinct changes in gene expression.

Using commercially available DNA slides, a team of researchers directed by Anand Swaroop, Ph.D., have established the first-ever gene profile of the aging human retina, an important step in understanding the mechanisms of aging and its impact on vision disorders.

In the August issue of Investigative Ophthalmology and Visual Science, Swaroop and colleagues show that retinal aging is associated, in particular, with expression changes of genes involved in stress response and energy metabolism.

The term gene expression means that in any given cell, only a portion of the genes are expressed or switched on. For example, a person's pancreas and retina have the same genes, but only the pancreas can turn on the genes that allow it to make insulin.

Swaroop believes that the findings will help scientists understand whether age predisposes one to changes in the retina that, in turn, lead to age-related diseases. For vision researchers, one of the most pressing disorders is age-related macular degeneration (AMD), a progressive eye disease that affects the retina and results in the loss of one's fine central vision.

"While we still don't know what causes AMD, we do know that the strongest factors are age and family history," says. Swaroop. "We are likely to find that AMD is caused by a complex interaction between genetic and environmental risk factors."

Microarray technology is an important tool for gene profiling because it allows rapid comparison of thousands of genes, something that was unheard of even few years ago. Shigeo Yoshida, M.D., Ph.D., a post-doctoral research fellow in Swaroop's laboratory, examined microarray slides containing DNA from 2,400 human genes.

After identifying the genes expressed in the retina (about half, or 1,200 genes), the res
'"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
26-Jun-2002


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers identify genes associated with aging the retina

(Date:8/21/2014)... Conn. , Aug. 21, 2014 Nxt-ID, ... the growing mobile commerce market, announced today that its ... common stock to be issued in its proposed underwritten ... approved for listing on The Nasdaq Capital Market, subject ... the common stock and warrants, and will trade under ...
(Date:8/21/2014)... study aimed at improving the food intake, health and ... homes is among three projects at the University of ... the Canadian Institutes of Health Research (CIHR). , ... Sciences at Waterloo, and a Schlegel research chair in ... to investigate why many Canadians living in long-term care ...
(Date:8/21/2014)... , Saturday to Wednesday, Oct. 18-22, 2014 , ... W. Harbor Drive, San Diego, CA 92101 , ... and other presentations of the latest research in ... plenary session featuring high-scoring abstracts on rare genetic ... various cancers, and treatment for sun sensitivity (Saturday, ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3Grants will fund landmark aging research at Waterloo 2American Society of Human Genetics 2014 Annual Meeting 2
(Date:8/22/2014)... New York (PRWEB) August 22, 2014 ... one of the interesting and challenging endeavors as ... renders highly impervious properties to the foreign substances. ... as possibility of self medication and minimal use ... low molecular weight drugs and provides specific targeting ...
(Date:8/22/2014)... Aug. 22, 2014 Research and Markets ... Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, ... report to their offering. The global ... in 2013, and is expected to grow at a ... Molecular biology enzymes, kits, & reagents find applications in ...
(Date:8/22/2014)... Canada (PRWEB) August 22, 2014 ... in model organisms can be accelerated by exome ... and manufacturing technologies, the custom SeqCap EZ Developer ... research. , Mr. Watson will additionally present how ... with commercially available human and mouse exome kits. ...
(Date:8/21/2014)... MD (PRWEB) August 21, 2014 DNA ... making progress in its development of JRC-LAMP-vax, an innovative ... cedar pollen. Phase IC studies began this month in ... to hay fever. , The Japanese red cedar releases ... people in Japan. Mountain Cedar pollen wreaks similar havoc ...
Breaking Biology Technology:Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Ocular Drug Delivery Technologies Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 4Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 3Efficient Identification of Protein-Coding Variants in a Model Organism Through Exome Sequencing, New Webinar Hosted by Xtalks 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4
Cached News: