HOME >> BIOLOGY >> NEWS
Researchers identify protein promoting vascular tumor growth

COLUMBUS, Ohio Researchers have discovered a new mechanism responsible for the growth of blood vessel tumors that can cause facial deformities in infants and young children, paving the way for an antibody-based treatment to remove cells that fuel the tumors' growth.

Blood vessel tumors require macrophages, a type of white blood cells, to develop. In studying these cells' role in tumor development, Ohio State University medical researchers determined that a protein called MCP-1 "recruits" macrophages to the vascular tumor site.

This means that therapies to eliminate the MCP-1 protein could be a key to healing or preventing the tumors and possibly others in which MCP-1 is expressed.

The results are published in the October issue of the American Journal of Physiology (Cell).

Blood vessel tumors affect up to 3 percent of all children, typically resulting in a prominent red mass on the head and neck. Up to one in four patients with hemangioendotheliomas, or HEs, the type of tumor used in these studies, die of anemia associated with the tumors.

The findings present the first evidence that MCP-1 and macrophages are needed for these tumors to grow, and the first evidence that anti-MCP-1 therapy prevents vascular tumor development in animals with intact immune systems, said Gayle Gordillo, lead author of the study, assistant professor of plastic surgery and an investigator in the Davis Heart and Lung Research Institute at Ohio State University Medical Center.

When MCP-1 recruits macrophages to the tumor site, it stimulates new blood vessel development, or angiogenesis, in endothelial cells that make up the lining of blood vessels. That proliferation can cause the tumors to grow because new vessels develop and allow blood to collect in the lesion. Gordillo, in partnership with Heart and Lung Research Institute investigators Chandan Sen and Sashwati Roy, determined MCP-1's role in recruiting macrophages by
'"/>

Contact: Emily Caldwell
caldwell.151@osu.edu
614-293-3737
Ohio State University
29-Sep-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers devise potent new tools to curb ivory poaching
4. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
5. Researchers ID chlorophyll-regulating gene
6. Researchers develop fast track way to discover how cells are regulated
7. Researchers identify distinctive signature for metastatic prostate cancer
8. Researchers report new gene test for isolated cleft lip and palate
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... ... March 09, 2019 , ... ... hM4Di ligands – exciting compounds for scientists studying GPCR and DREADD signalling. Hello ... and the National Institute of Neurological Disorders and Stroke, both institutes of the ...
(Date:2/27/2019)... ... 2019 , ... Fluxion Biosciences, a leading developer of precision solutions for life ... grant for further development of its ERASE-Seq liquid biopsy technology. The Phase I grant ... Dr. Omar Mian at the Cleveland Clinic. , Liquid biopsies offer the potential to ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... precision medicine, the traditional line between engineering and medical science grows ever thinner. ... smarter, the medical device industry is making medical practice easier for doctors, more ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... March 19, 2019 , ... ... in Israel and the Middle East region, and Swiss-based CDMO Lonza announced ... platform. The partnership will enable Sheba to vastly streamline its in-house cell ...
(Date:3/14/2019)... PRINCETON, N.J. (PRWEB) , ... March 14, 2019 , ... ... will create challenges for companies to keep up. Traditional Regulatory intelligence ... times and adapting technology to get global Regulatory teams right Insights faster and cheaper. ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... gold standard solution for preclinical research organizations. It is a low code, ... connected systems and facilities, innovative technology-driven automated data capture and seamless data ...
(Date:3/9/2019)... SAN DIEGO (PRWEB) , ... March 07, 2019 ... ... Agilent Technologies, is a pioneer in the development and commercialization of high performance, ... and PhysioStim, a leading European CRO with GLP-certified expertise in cardiovascular pharmacology and ...
Breaking Biology Technology:
Cached News: