HOME >> BIOLOGY >> NEWS
Researchers identify protein promoting vascular tumor growth

COLUMBUS, Ohio Researchers have discovered a new mechanism responsible for the growth of blood vessel tumors that can cause facial deformities in infants and young children, paving the way for an antibody-based treatment to remove cells that fuel the tumors' growth.

Blood vessel tumors require macrophages, a type of white blood cells, to develop. In studying these cells' role in tumor development, Ohio State University medical researchers determined that a protein called MCP-1 "recruits" macrophages to the vascular tumor site.

This means that therapies to eliminate the MCP-1 protein could be a key to healing or preventing the tumors and possibly others in which MCP-1 is expressed.

The results are published in the October issue of the American Journal of Physiology (Cell).

Blood vessel tumors affect up to 3 percent of all children, typically resulting in a prominent red mass on the head and neck. Up to one in four patients with hemangioendotheliomas, or HEs, the type of tumor used in these studies, die of anemia associated with the tumors.

The findings present the first evidence that MCP-1 and macrophages are needed for these tumors to grow, and the first evidence that anti-MCP-1 therapy prevents vascular tumor development in animals with intact immune systems, said Gayle Gordillo, lead author of the study, assistant professor of plastic surgery and an investigator in the Davis Heart and Lung Research Institute at Ohio State University Medical Center.

When MCP-1 recruits macrophages to the tumor site, it stimulates new blood vessel development, or angiogenesis, in endothelial cells that make up the lining of blood vessels. That proliferation can cause the tumors to grow because new vessels develop and allow blood to collect in the lesion. Gordillo, in partnership with Heart and Lung Research Institute investigators Chandan Sen and Sashwati Roy, determined MCP-1's role in recruiting macrophages by
'"/>

Contact: Emily Caldwell
caldwell.151@osu.edu
614-293-3737
Ohio State University
29-Sep-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers devise potent new tools to curb ivory poaching
4. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
5. Researchers ID chlorophyll-regulating gene
6. Researchers develop fast track way to discover how cells are regulated
7. Researchers identify distinctive signature for metastatic prostate cancer
8. Researchers report new gene test for isolated cleft lip and palate
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... 2017 Forecasts by Product Type ... by End-Use (Transportation & Logistics, Government & Public Sector, ... Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation ... Are you looking for a definitive report on the ... ...
(Date:4/5/2017)... -- Today HYPR Corp. , leading innovator in ... the HYPR platform is officially FIDO® Certified . ... that empowers biometric authentication across Fortune 500 enterprises and ... 15 million users across the financial services industry, however ... suites and physical access represent a growing portion of ...
(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... 2017 , ... Arrowhead Publishers is pleased to announce the ... San Diego, CA on September 27-28, 2017. Leaders from the pharmaceutical, biotech, device ... the treatment of various types of pain. There are also extended networking opportunities, ...
(Date:4/27/2017)... ... April 27, 2017 , ... ... mass flow controllers based on capillary thermal mass flow technology provide exponentially more ... control applications. Over 80% of all industrial processes—such as those involving chemical ...
(Date:4/27/2017)... Washington, USA (PRWEB) , ... April 27, 2017 ... ... for optics and photonics , joined other scientists, researchers, engineers, and industry professionals ... measures to strengthen America's ability to compete in the world photonics industry. , ...
(Date:4/27/2017)... 2017  Pendant Biosciences, Inc. (formerly Nanoferix, Inc.), a ... drug delivery technologies, today announced that it has been ... Toronto . Shawn Glinter ... noted, "We are excited to become part of the ... are honored to be the first Tennessee ...
Breaking Biology Technology:
Cached News: