HOME >> BIOLOGY >> NEWS
Researchers identify protein promoting vascular tumor growth

COLUMBUS, Ohio Researchers have discovered a new mechanism responsible for the growth of blood vessel tumors that can cause facial deformities in infants and young children, paving the way for an antibody-based treatment to remove cells that fuel the tumors' growth.

Blood vessel tumors require macrophages, a type of white blood cells, to develop. In studying these cells' role in tumor development, Ohio State University medical researchers determined that a protein called MCP-1 "recruits" macrophages to the vascular tumor site.

This means that therapies to eliminate the MCP-1 protein could be a key to healing or preventing the tumors and possibly others in which MCP-1 is expressed.

The results are published in the October issue of the American Journal of Physiology (Cell).

Blood vessel tumors affect up to 3 percent of all children, typically resulting in a prominent red mass on the head and neck. Up to one in four patients with hemangioendotheliomas, or HEs, the type of tumor used in these studies, die of anemia associated with the tumors.

The findings present the first evidence that MCP-1 and macrophages are needed for these tumors to grow, and the first evidence that anti-MCP-1 therapy prevents vascular tumor development in animals with intact immune systems, said Gayle Gordillo, lead author of the study, assistant professor of plastic surgery and an investigator in the Davis Heart and Lung Research Institute at Ohio State University Medical Center.

When MCP-1 recruits macrophages to the tumor site, it stimulates new blood vessel development, or angiogenesis, in endothelial cells that make up the lining of blood vessels. That proliferation can cause the tumors to grow because new vessels develop and allow blood to collect in the lesion. Gordillo, in partnership with Heart and Lung Research Institute investigators Chandan Sen and Sashwati Roy, determined MCP-1's role in recruiting macrophages by
'"/>

Contact: Emily Caldwell
caldwell.151@osu.edu
614-293-3737
Ohio State University
29-Sep-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers devise potent new tools to curb ivory poaching
4. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
5. Researchers ID chlorophyll-regulating gene
6. Researchers develop fast track way to discover how cells are regulated
7. Researchers identify distinctive signature for metastatic prostate cancer
8. Researchers report new gene test for isolated cleft lip and palate
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... June 30, 2017 Today, American Trucking ... supplier of face and eye tracking software, became ... provider program. "Artificial intelligence and ... to monitor a driver,s attentiveness levels while on ... able to detect fatigue and prevent potential accidents, ...
(Date:6/14/2017)... -- IBM (NYSE: IBM ) is introducing several innovative partner ... developing collaboration between startups and global businesses, taking place in ... event, nine startups will showcase the solutions they have built ... France is one of ... 30 percent increase in the number of startups created between ...
(Date:5/16/2017)... 2017  Veratad Technologies, LLC ( www.veratad.com ), an ... identity verification solutions, announced today they will participate as ... 15 thru May 17, 2017, in Washington ... Center. Identity impacts the lives of ... quickly evolving digital world, defining identity is critical to ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... The award-winning producers behind ... to feature new innovations aimed at helping farmers solve the problem of nitrogen ... airs Tuesdays at 8:30aET on RFD-TV. Check your local listings for more info. ...
(Date:9/20/2017)... ... September 20, 2017 , ... ... of a study examining the effects of exoskeleton-assisted walking on gait parameters ... (SCI). The article, "Neuromechanical adaptations during a robotic powered exoskeleton assisted walking ...
(Date:9/19/2017)... ... September 19, 2017 , ... Participants of this educational webinar ... hood. Along with the advantages and disadvantages of ductless, filtered fume hoods, they ... the laboratory. , Attendees will learn from an industry expert about the different ...
(Date:9/19/2017)... -- ValGenesis Inc., the global leader in Enterprise Validation ... strategic partnership with VTI Life Sciences (VTI). This partnership ... the latest technology available in the ValGenesis VLMS system. ... and cost-effective validation services using ValGenesis VLMS. VTI will ... system. The partnership ...
Breaking Biology Technology:
Cached News: