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Researchers identify protein promoting vascular tumor growth

The trick will be regulating MCP-1 levels safely, because the protein also is called to action to help wounds heal. Macrophages recruited in these cases make free radicals and promote angiogenesis that is beneficial in the wound-healing process.

"There are times when you want to promote angiogenesis, but not with tumors, because it contributes to tumor growth," Gordillo said. "MCP-1 can be brought in as a repair response to help people with wounds, but it can make negative contributions to the health and well-being of people with tumors."

Because angiogenesis is implicated in the development of other kinds of tumors and chronic inflammatory conditions, OSU scientists say the findings of this study suggest anti-MCP-1 therapy may be a useful approach for other diseases. "This study's identification of the role of MCP-1 expression has obvious potential for other tumors, as well," Gordillo said. "The concept could be applicable to a broad variety of tumors in which we know MCP-1 is expressed."


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Contact: Emily Caldwell
caldwell.151@osu.edu
614-293-3737
Ohio State University
29-Sep-2004


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