HOME >> BIOLOGY >> NEWS
Researchers learn certain enzyme inhibitors may help in cancer therapy following initial procedures

DALLAS Sept. 15, 2003 Certain enzyme inhibitors may slow tumor formation within weeks and could lead to treatments that retard or prevent recurrences of cancers, researchers at UT Southwestern Medical Center at Dallas have discovered.

Their findings appear in the current issue of the journal Cancer Research.

The researchers sought to inhibit telomerase, an enzyme that maintains telomeres repeating sequences of DNA at the end of each chromosome that are believed to function as a counting mechanism for cellular aging. Telomerase prevents the shortening of the sequences of DNA that occurs in normal cells as they age. The enzyme is found in most types of tumor cells but not healthy cells, indicating telomerase inhibitors may be a powerful new approach to chemotherapy.

Telomerase inhibition, however, has posed challenges for therapy. In earlier studies, scientists have found that months of treatment with an inhibitor are required before tumor growth could be expected to significantly slow.

The UT Southwestern researchers treated cultured human tumor cells with a unique compound that blocks telomerase activity, and the cell proliferation slowed substantially after just a few weeks.

Further, prostate cancer cells treated with the inhibitor barely formed tumors in mice and yielded very low levels of prostate specific antigen (PSA), a marker associated with malignancy. Cells treated with a similar compound that was not a telomerase inhibitor formed large tumors with high PSA levels.

"Telomerase is widely appreciated as a promising target for therapy," said Dr. David Corey, professor of pharmacology and biochemistry and the study's senior author. "Our results suggest that if you can inhibit telomerase in tumor cells and shorten telomeres, you will slow the growth of tumors."

The researchers also discovered that when the telomerase inhibitor is combined with standard cancer therapeutic agents carboplatin and cisplatin
'"/>

Contact: Scott Maier
scott.maier@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Sep-2003


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 23, 2020 , ... Kemp ... announced that the company has received ISO9001:2015 certification for the development and ... industries. The decision to pursue ISO9001 accreditation demonstrates Kemp’s commitment to a ...
(Date:6/23/2020)... THE WOODLNDS, Texas (PRWEB) , ... June 23, ... ... in X-ray analytical instrumentation, is pleased to announce the next event in a ... of X-ray scattering. , The TOPIQ series of webinars was developed in response ...
(Date:6/19/2020)... ... June 18, 2020 , ... ... series, “Automate Your Lab with Software for Data Decisions,” for pharmaceutical and ... how to integrate and automate cutting-edge scientific instruments and laboratory equipment from ...
Breaking Biology News(10 mins):
(Date:6/2/2020)... ... June 01, 2020 , ... As part ... positive change in the world, enterprise security solutions provider bitsIO donated time to ... working from home during self-quarantines and shelter-in-place orders, companies are increasingly concerned about ...
(Date:5/28/2020)... ... 28, 2020 , ... Genedata, the leading provider of enterprise ... ® 17.0, the latest version of its enterprise software for the automated analysis, ... will host a webinar on June 10, 2020, detailing and demonstrating the features ...
(Date:5/21/2020)... ... May 21, 2020 , ... Threats to intellectual property, political ... Contrary to conventional wisdom that says the coronavirus pandemic will generally benefit biopharmaceutical ... from the pandemic commercially weaker, dealing with delays in new product launches and ...
(Date:5/21/2020)... Calif. (PRWEB) , ... May 20, 2020 , ... ... the addition of Simon Prakash, who will serve as the company’s executive vice ... at a time when Exo is disrupting the medical imaging space, bringing more ...
Breaking Biology Technology:
Cached News: