HOME >> BIOLOGY >> NEWS
Researchers learn certain enzyme inhibitors may help in cancer therapy following initial procedures

DALLAS Sept. 15, 2003 Certain enzyme inhibitors may slow tumor formation within weeks and could lead to treatments that retard or prevent recurrences of cancers, researchers at UT Southwestern Medical Center at Dallas have discovered.

Their findings appear in the current issue of the journal Cancer Research.

The researchers sought to inhibit telomerase, an enzyme that maintains telomeres repeating sequences of DNA at the end of each chromosome that are believed to function as a counting mechanism for cellular aging. Telomerase prevents the shortening of the sequences of DNA that occurs in normal cells as they age. The enzyme is found in most types of tumor cells but not healthy cells, indicating telomerase inhibitors may be a powerful new approach to chemotherapy.

Telomerase inhibition, however, has posed challenges for therapy. In earlier studies, scientists have found that months of treatment with an inhibitor are required before tumor growth could be expected to significantly slow.

The UT Southwestern researchers treated cultured human tumor cells with a unique compound that blocks telomerase activity, and the cell proliferation slowed substantially after just a few weeks.

Further, prostate cancer cells treated with the inhibitor barely formed tumors in mice and yielded very low levels of prostate specific antigen (PSA), a marker associated with malignancy. Cells treated with a similar compound that was not a telomerase inhibitor formed large tumors with high PSA levels.

"Telomerase is widely appreciated as a promising target for therapy," said Dr. David Corey, professor of pharmacology and biochemistry and the study's senior author. "Our results suggest that if you can inhibit telomerase in tumor cells and shorten telomeres, you will slow the growth of tumors."

The researchers also discovered that when the telomerase inhibitor is combined with standard cancer therapeutic agents carboplatin and cisplatin
'"/>

Contact: Scott Maier
scott.maier@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
15-Sep-2003


Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... ... 2019 , ... Rigaku Corporation , a global leader ... & Microanalysis 2019 Meeting ( M&M 2019 ), taking place August 4 - ... & Microanalysis Meeting, organized by the Microscopy Society of America, is the world’s ...
(Date:8/1/2019)... ... August 01, 2019 , ... John R. Freeman, CPA, has joined BioLabs ... and president of BioLabs, which provides premier co-working spaces for life science startups in ... ability to forecast and manage growth,” says Fruehauf. “BioLabs has expanded to 10 locations ...
(Date:7/26/2019)... LOS ANGELES (PRWEB) , ... July 26, 2019 ... ... pleased to announce an exclusive interview with Helius Medical Technologies CEO Phil Deschamps ... or trauma. , Helius Medical Technologies is a neurotech company in ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... 22, 2019 , ... An upcoming episode of Advancements with ... 4Q/2019. Check your local listings for more information. , This segment will educate ... on therapeutics for children and the elderly, viewers will learn about Avro’s core ...
(Date:8/7/2019)... ... , ... Locus Agricultural Solutions (Locus AG) reports record levels of carbon sequestered ... Rhizolizer ® , which is pulling up to 121% more carbon into the soil ... Results from the treatment of almonds, cherries, turf/sod, grapes and citrus across the U.S., ...
(Date:8/4/2019)... ... ... Cirtec Medical Corporation, a strategic outsourcing partner for complex medical devices, including active implantables ... sq. ft. manufacturing facility in the Coyol free zone, located in Alajuela, Costa ... to be fully operational by the end of the year, will be the company’s ...
(Date:7/19/2019)... ... July 18, 2019 , ... ... “Ravi Everest,” will be joining forces with California-based charity Coalition Duchenne for its ... 20-22nd. Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy and was ...
Breaking Biology Technology:
Cached News: