HOME >> BIOLOGY >> NEWS
Researchers one step closer to Holy Grail of neurobiology

For scientists in the field of neurobiology, defining the factors that influence the arousal of brain and behavior is a "Holy Grail." Research published by Rockefeller University scientists in the Aug. 11 issue of Proceedings of the National Academy of Sciences Early Edition are the first to give a rigorous definition of what is meant by arousal, considered to be at the base of all emotionally laden behaviors. In particular, the researchers, led by Donald W. Pfaff, Ph.D., provide an operational definition of arousal that scientists can pursue and measure quantitatively in laboratory animals, as well as in human beings.

"If you ask someone on the street what arousal means, that person might have an intuitive concept of arousal in terms of sexual excitement, alertness or an emotional response such as fear," says Pfaff, professor and head of the Laboratory of Neurobiology and Behavior at Rockefeller. "But, if you ask, 'Exactly what does arousal mean scientifically,' it's been very hard for scientists to pin down."

Scientists who study arousal historically were divided into two camps: those who consider arousal to be a single, "monolithic" physiological function, and those who believe that arousal does not exist as a whole, but is a collection of small specific abilities.

In the PNAS paper, Pfaff and colleagues present a mathematical equation that for the first time unifies these two disparate schools of thought and combines generalized arousal with various specific forms of arousal, such as sex, hunger and fear. They also show that experiments can be designed to measure arousal in laboratory mice, which ultimately will provide genetic answers to the question "what is arousal?"

In humans, deficits in arousal contribute to such cognitive problems as attention deficit hyperactivity disorder, autism and Alzheimer's disease. Erosion of arousal also may account for some of the mental difficulties that people face as they age. Understa
'"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
14-Aug-2003


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2019)... ... January 10, 2019 , ... When Dr. James L. ... , was invited to contribute a chapter to the new book Perinatal Stem Cells: ... continue Asymmetrex’s effort to address a debilitating secret of stem cell medicine. For ...
(Date:1/8/2019)... ... January 07, 2019 , ... Sonion ... for hearing instruments and specialty earphones, and Valencell , the leading innovator ... receiver in canal with an embedded biometric sensor. The BiometRIC measures key vital ...
(Date:1/4/2019)... WORTH, Texas (PRWEB) , ... January 02, 2019 ... ... catalog. This release is particularly noteworthy, as the life science tools and service ... history, it is offering a catalog. The catalog features not just part numbers ...
Breaking Biology News(10 mins):
(Date:1/20/2019)... Milwaukee (PRWEB) , ... January 17, 2019 , ... The ... release of its Patient Education program , a new initiative for 2019. Designed ... is designed to educate and inform patients, families, and the public on the status ...
(Date:1/15/2019)... BROOK, Ill. (PRWEB) , ... January 15, 2019 , ... ... risk factors for worsening kidney disease, according to a new study published in the ... stage and are frequently treated with partial nephrectomy, a surgical procedure in which the ...
(Date:1/11/2019)... ... January 11, 2019 , ... Drawing on over 22 years of software ... at 2:30pm EST will explore some of the key lessons that have driven customer ... vs. using multiple vendors, and find out how to ensure that you continue to ...
(Date:1/10/2019)... ... January 08, 2019 , ... VGI Medical was founded ... a leader in bringing innovation to the market including VerteLoc, CerLoc, SiJoin and VerteLP. ... joint by utilizing a unique patented dual geometric design to limit motion of the ...
Breaking Biology Technology:
Cached News: