HOME >> BIOLOGY >> NEWS
Researchers one step closer to Holy Grail of neurobiology

For scientists in the field of neurobiology, defining the factors that influence the arousal of brain and behavior is a "Holy Grail." Research published by Rockefeller University scientists in the Aug. 11 issue of Proceedings of the National Academy of Sciences Early Edition are the first to give a rigorous definition of what is meant by arousal, considered to be at the base of all emotionally laden behaviors. In particular, the researchers, led by Donald W. Pfaff, Ph.D., provide an operational definition of arousal that scientists can pursue and measure quantitatively in laboratory animals, as well as in human beings.

"If you ask someone on the street what arousal means, that person might have an intuitive concept of arousal in terms of sexual excitement, alertness or an emotional response such as fear," says Pfaff, professor and head of the Laboratory of Neurobiology and Behavior at Rockefeller. "But, if you ask, 'Exactly what does arousal mean scientifically,' it's been very hard for scientists to pin down."

Scientists who study arousal historically were divided into two camps: those who consider arousal to be a single, "monolithic" physiological function, and those who believe that arousal does not exist as a whole, but is a collection of small specific abilities.

In the PNAS paper, Pfaff and colleagues present a mathematical equation that for the first time unifies these two disparate schools of thought and combines generalized arousal with various specific forms of arousal, such as sex, hunger and fear. They also show that experiments can be designed to measure arousal in laboratory mice, which ultimately will provide genetic answers to the question "what is arousal?"

In humans, deficits in arousal contribute to such cognitive problems as attention deficit hyperactivity disorder, autism and Alzheimer's disease. Erosion of arousal also may account for some of the mental difficulties that people face as they age. Understa
'"/>

Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
14-Aug-2003


Page: 1 2 3 4

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2019)... ... March 09, 2019 , ... ... hM4Di ligands – exciting compounds for scientists studying GPCR and DREADD signalling. Hello ... and the National Institute of Neurological Disorders and Stroke, both institutes of the ...
(Date:2/27/2019)... ... 2019 , ... Fluxion Biosciences, a leading developer of precision solutions for life ... grant for further development of its ERASE-Seq liquid biopsy technology. The Phase I grant ... Dr. Omar Mian at the Cleveland Clinic. , Liquid biopsies offer the potential to ...
(Date:2/22/2019)... ... February 20, 2019 , ... ... precision medicine, the traditional line between engineering and medical science grows ever thinner. ... smarter, the medical device industry is making medical practice easier for doctors, more ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... March 19, 2019 , ... ... in Israel and the Middle East region, and Swiss-based CDMO Lonza announced ... platform. The partnership will enable Sheba to vastly streamline its in-house cell ...
(Date:3/14/2019)... PRINCETON, N.J. (PRWEB) , ... March 14, 2019 , ... ... will create challenges for companies to keep up. Traditional Regulatory intelligence ... times and adapting technology to get global Regulatory teams right Insights faster and cheaper. ...
(Date:3/14/2019)... ... March 14, 2019 , ... ... gold standard solution for preclinical research organizations. It is a low code, ... connected systems and facilities, innovative technology-driven automated data capture and seamless data ...
(Date:3/9/2019)... SAN DIEGO (PRWEB) , ... March 07, 2019 ... ... Agilent Technologies, is a pioneer in the development and commercialization of high performance, ... and PhysioStim, a leading European CRO with GLP-certified expertise in cardiovascular pharmacology and ...
Breaking Biology Technology:
Cached News: