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Researchers pave the way to protein therapy in humans

PTD didn't work its magic in the brain by destroying the blood-brain barrier. And the animals had no visible behavioral changes or other differences compared with untreated mice.

Dowdy has since tested modified versions of the PTD that should allow proteins to enter brain cells and other cells even more rapidly. And he is using his new technology to determine whether a malfunctioning protein helps jump-start cancer.

He notes that the laboratory's protein-targeting technology also may enable companies to create drugs that act only in disease-related cells, opening up a completely novel avenue of therapeutic approaches. "We can now do things in normal cells of mice that you could never even dream of doing with any reliability a year ago," Dowdy says.


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Contact: Barbra Rodriguez
rodrigub@medicine.wustl.edu
314-286-0122
Washington University School of Medicine
3-Sep-1999


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