Researchers question drug for chronic fatigue syndrome

Fludrocortisone, a drug prescribed to treat low blood pressure, has little or no effect on symptoms of chronic fatigue syndrome in adults when it is used as the only form of treatment, according to a joint study by the Johns Hopkins Children's Center and the National Institute of Allergy and Infectious Diseases (NIAID). A report of the study appears in this week's Journal of the American Medical Association.

In a preliminary study published in 1995, Peter Rowe, M.D., leader of the Johns Hopkins team, reported that many patients diagnosed with chronic fatigue syndrome (CFS) developed lightheadedness, fatigue, and sometimes fainted when they stood for prolonged periods of time. When tilted head-up on a special diagnostic table, most patients developed a sudden drop in blood pressure known as neurally mediated hypotension (NMH). Some study participants reported substantial relief in their lightheadedness and CFS symptoms when treated with a combination of an increase in dietary sodium chloride (table salt), fludrocortisone, and other medications. Fludrocortisone helps to maintain a normal blood pressure by reducing the loss of sodium from the bloodstream.

The researchers conducted the current, more rigorous study to determine whether isolating one component of the treatment fludrocortisone would be equally effective in treating symptoms. Over nine weeks, 50 adults with both CFS and NMH received fludrocortisone, and 50 received a placebo. Neither group took supplemental sodium. During the study, investigators and study participants were unaware of who received the fludrocortisone or the placebo. At the end of the treatment period, 14 percent of those treated with fludrocortisone described a notable improvement in overall well-being, compared with 10 percent in the placebo group, a difference that was not deemed statistically significant by researchers.

Since this current study began in 1996, other studies have identified four drugs effective in tr

Contact: Staci Vernick
Johns Hopkins Medical Institutions

Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:4/16/2020)... ... April 15, 2020 , ... With ... to create a vaccine to this novel virus. In an effort to accelerate ... Complex Systems (LRC), is announcing the development of Sample.Exchange, a web-based platform ...
(Date:4/14/2020)... NY (PRWEB) , ... April 14, 2020 , ... ... foam bedding and innovative home comfort technologies, announced today its planned donation of ... organizations in need of masks protect against the COVID-19 pandemic. , “At the ...
(Date:4/9/2020)... (PRWEB) , ... April 08, 2020 , ... ... Dr. Oligo 768XLc, the most commercially advanced platform for high throughput nucleic acid ... the needs of organizations focused on diagnostic and therapeutic applications for various viruses, ...
Breaking Biology News(10 mins):
(Date:5/21/2020)... ... May 21, 2020 , ... ... will cause long-term harm , Contrary to conventional wisdom that says the coronavirus ... finds many companies will emerge from the pandemic commercially weaker, dealing with delays ...
(Date:5/21/2020)... ... 19, 2020 , ... Eaton Square is pleased to announce its growth on ... biotechnology and medical technology-focused strategy and M&A advisory firm. , This is an important ... US and Asia Pacific healthcare innovators with capital and investors. , Popper and Company, ...
(Date:5/15/2020)... ... May 14, 2020 , ... ... human mesenchymal stem/stromal cell (hMSC) working cell banks and hMSC bioprocess systems, ... streamlined and multi-format collection of hMSC-derived extracellular vesicles (EVs). RoosterCollect™-EV-CC is the ...
(Date:5/15/2020)... ... May 14, 2020 , ... This new service offers clients a ... pressing questions answered quickly as the need arises. Lachman’s OnCall SMEs have extensive knowledge ... affordable rates. , Lachman OnCall™ SMEs are available normal business hours Monday through ...
Breaking Biology Technology:
Cached News: