Researchers have developed a new genetic test that can help predict whether parents who have one child with the "isolated" form of cleft lip or palate are likely to have a second child with the same birth defect. Isolated clefts account for 70 percent of all cleft lip and palate cases.

The National Institute of Environmental Health Sciences, the National Institute of Dental and Craniofacial Research, and the National Institute of General Medical Sciences provided funding for the study. All three agencies are components of the National Institutes of Health. The study results appear in the August 19 issue of the New England Journal of Medicine.

"This study shows that we've reached a point where it's possible to take blood samples from parents, test certain genes, and determine whether their risk for a second child with cleft lip or palate is, say, 1 percent or 20 percent," said Jeffrey Murray, M.D., a scientist at the University of Iowa and senior author on the study. "Now is the time to begin thinking about how best to apply these types of tests clinically and ensure that they truly benefit the families and their children."

Isolated clefts arise during fetal development from a dynamic interplay of genes, diet, and environmental factors, and current research tools are just beginning to cut through the complexity. Though the condition is usually correctable with several surgeries, families undergo tremendous emotional and economic hardship during the process. Children with this condition often require many other services, including complex dental care and speech therapy.

"These results show that a specific gene plays a crucial role in the development of isolated cleft lip and palate," said Dr. Kenneth Olden, director of NIEHS. "This discovery will provide parents with important information that will enable them to make informed decisions about future pregnancies."

According to Murray, babies born with the isolated form of cleft lip
'"/>

Contact: John Peterson
peterso4@niehs.nih.gov
919-541-7860
NIH/National Institute of Environmental Health Sciences
10-Sep-2004

Page: 1 2 3
Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains