HOME >> BIOLOGY >> NEWS
Researchers report new gene test for isolated cleft lip and palate

and palate do not have other birth defects often associated with this condition. Roughly one in every 600 babies in the United States is born with the isolated cleft lip and palate.

The authors say this latest gene test, when used with parents who already have one child with isolated cleft lip and palate, can predict this birth defect in subsequent children about 12 percent of the time. Utilizing this new gene test along with others that have already been developed, scientists now can collectively predict about 15 percent of isolated cleft lip and palate cases, impossible just a few years ago.

One of the first diagnostic tools of its kind, the gene test is based on distinct mutations in and around the gene IRF6, which encodes a specific protein that plays a vital role in the normal formation of the lips, palate, skin and genitalia during the early stages of development. The researchers found that mutations of the IRF6 gene are associated with an increased chance that a child would be born with a cleft lip or palate.

Two years ago, Murray and colleagues found that the IRF6 gene plays a role in Van der Woude Syndrome, a condition in which babies are born with clefts that are accompanied by other birth defects. There are more than 150 such syndromes, accounting for the remaining 30 percent of all cleft lip and palate.

Upon detailed analysis of the IRF6 gene, the researchers noticed a variation in the DNA sequence that they guessed may play a role in causing isolated clefts. The team reasoned the variation would somehow interfere with the normal biological activities of the IRF6 protein during tissue and organ development.

To test their hypothesis, the researchers focused their attention on a pool of 1,968 families, in Europe, South America, and Asia, with a history of isolated clefts. According to Murray, the rate of isolated clefts in some parts of the world, such as the Philippines, Brazil, and China, is even higher than in th
'"/>

Contact: John Peterson
peterso4@niehs.nih.gov
919-541-7860
NIH/National Institute of Environmental Health Sciences
10-Sep-2004


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers discover why mutant gene causes colon cancer
10. Researchers identify the genomes controlling elements
11. Researchers improve detection of diverse anthrax strains

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2018)... (PRWEB) , ... December 06, 2018 , ... ... research, selling instruments, consumables and laboratory contract services, throughout his career. During his ... developed a US Sales team and established the commercial laboratory operations in Brunswick, ...
(Date:12/5/2018)... (PRWEB) , ... December 03, 2018 , ... ... Cartessa Aesthetics , an emerging leader in the distribution and marketing of cutting-edge ... rapid growth, projecting $20MM in sales for 2018. Cartessa’s success can be ...
(Date:12/5/2018)... ... December 04, 2018 , ... Biolytic Lab Performance ... Oligo 192c, built on Biolytic’s Molecule Synthesis Platform. , Now restructured with ... become the world’s fastest in oligonucleotide synthesis, the 192c incorporates a multitude of ...
Breaking Biology News(10 mins):
(Date:11/28/2018)... ... November 28, 2018 , ... Earlier this month, Lajollacooks4u's Founder and Chef Jodi ... the height of truffle season. , Her first stop was Umbria, a ... the exclusive Black Truffle Lodge in the small mountain village of Pettino, Chef Jodi ...
(Date:11/20/2018)... ... ... Each year Forbes receives thousands of nominations for candidates wishing to be selected for ... years of age. The Forbes 30 Under 30 list showcases the top 30 individuals ... Science. , In 2017, Visikol CEO Dr. Michael Johnson was named to the ...
(Date:11/13/2018)... , ... November 12, 2018 , ... ... state-of-the-art practices in Alpharetta and Sandy Springs, now welcomes new patients for MTM® ... discreet and comfortable alternative to traditional braces in the Sandy Springs and Alpharetta ...
(Date:11/9/2018)... ... November 08, 2018 , ... ... Valenzuela, PhD, co-Founder, Chief Executive Officer and President of Andes Biotechnologies, to its ... the world, Dr. Valenzuela brings to uBiome expertise on the genetic studies of ...
Breaking Biology Technology:
Cached News: