HOME >> BIOLOGY >> NEWS
Researchers reveal insidious role of a 'serpin' in Alzheimer's Disease

Researchers led by investigators at the Gladstone Institute of Neurological Disease and the University of California, San Francisco have discovered that the protein alpha1-antichymotrypsin can double the accumulation of Alzheimer's disease-associated amyloid plaque in the brains of mice, suggesting a possible new target for therapy in humans.

Alpha1-antichymotrypsin (ACT) is a serin protease inhibitor, or serpin, that normally prevents enzymes known as proteases from digesting proteins. Scientists have known for some time that production of ACT is increased in the brains of patients with Alzheimer's disease, where it is bound tightly to amyloid proteins in abnormal deposits called plaques. These plaques, along with tangled nerve fibers known as neurofibrillary tangles, are the main pathological hallmarks of Alzheimer's disease.

However, researchers have not known whether ACT counteracts or augments the build-up and possible toxicity of amyloid proteins. Some previous studies performed in cultured cells or with proteins themselves have found that ACT decreases the aggregation of amyloid proteins, while others have found the opposite effect or no effect at all.

The current study, conducted in genetically engineered mice, reveals that increased production of ACT in the brain strongly increases the build-up of amyloid proteins, which is associated with damage to brain cells within and around the plaques.

"We speculate that reducing or inhibiting the plaque-enhancing activity of ACT could help prevent the accumulation of plaques in the brain," says the lead author of the study, Lennart Mucke, MD, director of the Gladstone Institute of Neurological Disease at the UCSF-affiliated San Francisco General Hospital Medical Center, and Joseph B. Martin Distinguished Professor at UCSF.

"There's a sneakiness to this protein," Mucke says. "While the association of ACT with plaques has been known for more than ten years, the true nature of its activity in
'"/>

Contact: Jennifer O'Brien
jobrien@pubaff.ucsf.edu
4154476-2557
University of California - San Francisco
4-Dec-2000


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: