e more abundant in plants than in other organisms. "Just as animals have immune systems, plants have ways of protecting themselves, too," Wilson explained. "As scientists begin to understand the genes that code for protective proteins, they may be able to make plants more resistant not only to diseases but to insects, wind and drought."

Scientists are comparing the Arabidopsis sequence to other fully sequenced genomes, including those of yeast, fruitflies and roundworms. By uncovering the genetic basis for similarities and differences between organisms, such work may shed light on evolution. For example, certain Arabidopsis genes appear to have moved to new locations within the genome. Further study may show how such genetic reshuffling has occurred in other organisms as well, giving them specific advantages in their environments.

The new data also will help scientists interpret the working draft of the human genome because many genes that perform basic functions have been retained during evolution. Knowing the locations and functions of Arabidopsis genes will allow scientists to pinpoint similar human genes and learn more about the causes of many disorders. "Gaining a better understanding of the functions genes perform in cells, whether plant or animal, is going to help us understand how to diagnose and treat diseases in humans," Wilson said.

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Contact: David Linzee
linzeed@medicine.wustl.edu
314-286-0119
Washington University School of Medicine
12-Dec-2000

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