Researchers solve the mystery of a key structure in immune system cells

If the immune system had a motto, new research shows that an appropriate one would be "No job too big or too small." A multi-center team has found that the system can respond to infections that range from sneak attacks to all-out onslaughts thanks to a doughnut-shaped molecular structure that forms between immune cells when they're communicating. The team has found that this structure not only serves to amplify the faint signals of an attacker, but also to mute overpowering signals that might otherwise "blind" the system.

The immune cell structure acts much like the iris in the eye, which adjusts to let vision function from very dark to very bright conditions, explains Michael Dustin, Ph.D., the Irene Diamond Associate Professor of Immunology at NYU School of Medicine, one of the study's lead authors. "If you're in a very dark room, you see by opening your iris and enhancing sensitivity to light," he explains. "But then if you get hit with a burst of light, momentarily you're blinded but then the system adapts, and that's like what the immune cells are doing in this process." This structure lets the body's immune system respond to signs of invasion over a huge range of magnitudes, he says.

Researchers are hopeful that now that the role of this channel of communication has been identified, it may serve as a potential target for treating diseases -- those in which the body attacks itself, such as in arthritis, as well as those in which the body doesn't recognize the attacker, such as tumors. "This could be the hidden factor in autoimmune disease," says Dr. Dustin.

The study was led by Dr. Dustin, Arup Chakraborty, Ph.D., Professor of Chemical Engineering and Chemistry at the University of California at Berkeley and faculty scientist at the Lawrence Berkeley National Laboratory, and Andrey Shaw, M.D., Professor of Pathology and Immunology at Washington University School of Medicine. Their findings are reported in the journal Science, which will

Contact: Pamela McDonnell
New York University Medical Center and School of Medicine

Page: 1 2 3 4 5

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:9/3/2020)... ... 03, 2020 , ... Litmus Health , the research-ready ... of the company’s security practices has been completed. The assessment deemed Litmus infrastructure ... evaluation reviewed Litmus’ processes and systems, assessing them to see whether they adhere ...
(Date:8/23/2020)... , ... August 21, 2020 , ... ... Corporation has been published and is now available on the company’s global ... diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. , ...
(Date:8/12/2020)... , ... August 11, 2020 , ... ... based in Princeton, NJ, have entered into license agreements with Housey Pharma’s HMI ... Both Roche and J&J have annual Research and Development spending in excess ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... DuPont Nutrition & ... Wuxi, China. The new plant operation will provide the local animal production industry ... , “This facility will improve the flexibility of our offerings to the Chinese ...
(Date:8/12/2020)... (PRWEB) , ... August 12, 2020 , ... ... Inc. (EMMA International), a global leader in FDA compliance consulting has been ... nation’s fastest-growing private companies. The list represents a unique look at the most ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader in ... “BUILDING FOR LIFE.” The adoption of this taglines comes at a time of ... capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. ...
(Date:7/31/2020)... MIAMI (PRWEB) , ... July 29, 2020 , ... ... nearly 200 of the top radiation centers in 16 countries, has reached its ... years, SDX® is now in routine use at top universities including University of ...
Breaking Biology Technology:
Cached News: