Researchers study metabolic, cardiovascular effects of caffeine consumed with naringin

by influencing Cytochrome P450 enzyme system, or CYP3A4. Many medications are metabolized in the liver by the cytochrome P450 enzyme complex or CYP3A4, including calcium channel blockers, HMG-CoA reductase inhibitors, anxiolytics, and some neuropsychiatrics. Adverse reactions have been reported by this drug-food interaction. The majority of caffeine (approximately 86 percent) is metabolized by a similar enzyme group, CYP1A2. Other enzymes (CYP2E1 and CYP3A4) play a minor role in caffeine metabolism. However, naringin, the bitter constituent of grapefruit juice, has been documented to inhibit CYP34A activity in human liver as well as CYP1A2.

A New Study New research has examined the metabolic and cardiovascular effects of caffeine consumed in conjunction with naringin. The authors of "Caffeine and Naringin (Grapefruit) Does Not Affect Resting Energy Expenditure" are Tasha L.P. Ballard and Matthew Vukovich, Ph.D., FACSM, of South Dakota State University, Brookings, SD. They will present their findings at the American Physiology Society (APS) conference, Experimental Biology 2003, being held April 11-15, at the San Diego Convention Center, San Diego, CA.

Dr. Vukovich hypothesized that a caffeine/naringin combined dosage would increase the half-life of caffeine and further alter metabolic markers and hemodynamic variables. The parameters of interest included oxygen consumption, respiratory exchange ratio, resting energy expenditure, heart rate and blood pressure.

Methodology Caffeine-nave subjects were studied before and after the ingestion of caffeine (C, 200mg) with and without naringin (100mg or 200mg). Data was collected for 8 hours every half-hour. Parameters measured included resting metabolic rate, heart rate, blood pressure, blood levels of caffeine.

Results The consumption of caffeine significantly increased resting metabolic rate or calories burned at rest. However, the addition of naringin did not furthe

Contact: Donna Krupa
American Physiological Society

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