Researchers to compare prenatal treatments for serious twin complication

-birth circulation.

Both treatments aim to obtain a more normal balance of amniotic fluid between the twins, although only the laser treatment addresses the underlying anatomical defect. However, the two treatments have not previously been directly compared in a clinical trial.

This study will evaluate which treatment, laser photocoagulation or amnioreduction, results in better survival rates and better cardiac, neurological and developmental outcomes. In addition to studying health outcomes immediately after birth, the researchers also will assess the twins neurodevelopment at age 18 to 22 months.

Twelve medical centers throughout the United States will participate in the TTTS trial, sponsored by the National Institutes of Health. While all 12 centers perform amnioreduction, only two, The Childrens Hospital of Philadelphia and the University of California, San Francisco, also perform fetoscopic laser coagulation. Those two institutions also are the only centers in the world offering comprehensive treatments in fetal surgery.

Enrollment for the multicenter TTTS study began in March 2002 and is scheduled to continue through March 2005. Throughout the country, researchers expect to recruit a total of 150 patients for the trial, of which approximately half will be recruited by The Children's Hospital of Philadelphia.

Because of the requirements of randomized studies, each mother who enrolls in the trial will be randomly assigned to either amnioreduction treatment or laser treatment. Participating centers will not perform the laser treatment outside of the clinical trial.


Contact: John Ascenzi
Children's Hospital of Philadelphia

Page: 1 2

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:

(Date:5/24/2016)... patient care by providing unparalleled technology to leaders of the medical imaging industry.  As ... added to the range of products distributed by Ampronix. Photo - ... ... ... ...
(Date:5/12/2016)... , May 12, 2016 WearablesResearch.com ... just published the overview results from the Q1 wave ... the recent wave was consumers, receptivity to a program ... data with a health insurance company. "We ... to share," says Michael LaColla , CEO of ...
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Cancer Foundation (PCF) is pleased to announce 24 new Young Investigator (YI) ... of the Class of 2016 were selected from a pool of 128 applicants ... the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
Breaking Biology Technology:
Cached News: