Researchers uncover a protein defect that causes a milder form of cystic fibrosis

causing the protein strands to stick together."

CFTR is a membrane protein with a massive and complicated structure. Membrane proteins, which regulate the stable internal physiological conditions of the cell in a controlled way, allowing for such things as intracellular communication, are very difficult to study.

"We had to develop and refine molecular biological techniques in order to accurately study this membrane protein. This research will add to the body of knowledge about membrane proteins, which are also implicated in other diseases such as cancer, diabetes, and hypertension," said Dr. Alex Therien, the study's lead author and a Canadian Institutes of Health Research (CIHR) postdoctoral fellow in Dr. Deber's lab. The other author on this paper is Fiona Grant, who was student in Dr. Deber's lab as part of the Samuel Lunenfeld Research Summer Student Program in the HSC Research Institute.


Contact: Jennifer ten Westeneind
The Hospital for Sick Children

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