HOME >> BIOLOGY >> NEWS
Researchers uncover biochemical connection between high-fat diets and increased colon-cancer risk

DALLAS May 17, 2002 Researchers at UT Southwestern Medical Center at Dallas have uncovered what could be a key clue in tracing the connection between high-fat diets and increased colon-cancer risk.

Their findings, published in todays edition of Science, reveal that the bodys natural mechanisms arent built to handle lithocholic acid, a toxic byproduct of dietary fat, in the volume generated by high-fat diets.

Dr. David Mangelsdorf, professor of pharmacology and investigator in the Howard Hughes Medical Institute (HHMI) at UT Southwestern, said observational evidence established a strong association between high-fat diets and colorectal cancer, but scientists could not explain the biological and biochemical mechanisms that formed the link.

The rate of colorectal cancer is much higher in the United States - where a high-fat diet is common - than in Japan, where people dont eat a lot of fat and colorectal cancer is almost nonexistent. But no one has understood why that is, he said.

The new findings show that at least part of the answer lies in the bodys inability to cope with large amounts of lithocholic acid, produced when the body processes cholesterol. The body produces bile acids when it breaks down cholesterol, part and parcel of dietary fat. Those bile acids go to the small intestine and are broken down into secondary bile acids, one of which is lithocholic acid.

Most secondary bile acids circulate to the liver, but only a little bit of lithocholic acid does so. Much of it remains in the small intestine, then moves into the colon, or large intestine.

Lithocholic acid is highly toxic, and it builds up in a high-fat diet, Mangelsdorf said. We dont know how it causes cancer; but it is known to cause cancer in mice, and people with colon cancer have high concentrations of it.

Scientists knew that a certain receptor controlled the small amount of lithocholic acid in the liver. Receptors are proteins that bind to
'"/>

Contact: Wayne Carter
Wayne.Carter@UTSouthwestern.edu
214-648-3404
UT Southwestern Medical Center
16-May-2002


Page: 1 2 3

Related biology news :

1. Researchers determine genetic cause of Timothy syndrome
2. Researchers find color sensitive atomic switch in bacteria
3. Researchers identify protein promoting vascular tumor growth
4. Researchers devise potent new tools to curb ivory poaching
5. Researchers create nanotubes that change colors, form nanocarpet and kill bacteria
6. Researchers ID chlorophyll-regulating gene
7. Researchers develop fast track way to discover how cells are regulated
8. Researchers identify distinctive signature for metastatic prostate cancer
9. Researchers report new gene test for isolated cleft lip and palate
10. Researchers discover why mutant gene causes colon cancer
11. Researchers identify the genomes controlling elements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2016)... PUNE, India , March 22, 2016 ... new market research report "Electronic Sensors Market for ... Fingerprint, Proximity, & Others), Application (Communication & ... and Geography - Global Forecast to 2022", ... consumer industry is expected to reach USD ...
(Date:3/18/2016)... LONDON , March 18, 2016 ... Established Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical ... & security companies in the border security market and ... and Europe has led ... your companies improved success. --> defence & ...
(Date:3/15/2016)... -- Yissum Research Development Company of the Hebrew ... Hebrew University, announced today the formation of Neteera ... human biological indicators. Neteera Technologies has completed its first ... ... emissions from sweat ducts, enables reliable and speedy biometric ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... ... ... Doctors in Italy say mesothelioma patients with the highest levels of a ... Mesothelioma has just posted an article on the new research. Click here to ... Italy tested the blood serum, tumors, and lung fluid of 45 mesothelioma patients ...
(Date:5/27/2016)... ... 2016 , ... Weeks after hosting a carpal tunnel syndrome workshop with Dr. ... and founder of the Fitzmaurice Hand Institute, has announced the addition of MRI diagnostic ... technology and only 1 of about 3 currently available in the United States. Developed ...
(Date:5/27/2016)... YORK , May 27, 2016 ... but investors playing in this space know that volatility is ... morning,s featured companies on ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: ... ), Lpath Inc. (NASDAQ: LPTN ), and Heat ... and gain access to the technical alerts for these stocks ...
(Date:5/26/2016)... , May 26, 2016 Despite the ... value in this space. Today,s pre-market research on ActiveWallSt.com directs ... Health Inc. (NASDAQ: RDUS ), Cerus Corp. (NASDAQ: ... ARWR ), and Five Prime Therapeutics Inc. (NASDAQ: ... briefings at: http://www.activewallst.com/ On ...
Breaking Biology Technology:
Cached News: