HOME >> BIOLOGY >> NEWS
Resistance To Leptin Contributes To Obesity

e increased potency of leptin in lean mice receiving the protein via ICV infusion and those receiving subcutaneous injections shows that the central nervous system, in particular the hypothalamus, is an important site of leptin action," says Friedman. "Indeed, chronic ICV infusions of very low doses of leptin replicate the weight-reducing effects of much higher doses of leptin given by injection. The basis for this apparent difference is not clear, but may suggest that the transport of leptin across the blood-brain barrier, which allows leptin to enter the brain from the body's blood stream, may be an important step in the body's processing of leptin's signal."

Specifically, in normal, lean mice, injecting leptin subcutaneously at an infusion rate of 200 ng per hour, for example, led to an increase in blood levels, from 5 to 7 ng/milliliter, and resulted in a 5 percent reduction in weight. A doubling of leptin levels led to a 9 percent reduction in weight, while a five-fold increase in leptin levels yielded a 15 percent weight loss.

Other lean mice receiving leptin through ICV infusion rapidly lost fat, reaching their lowest weight by the eighth day of treatment and maintained it for the remainder of the 30-day infusion period. The mice reduced their food intake to its lowest level, a drop of more than 50 percent, by the third day, but their food intake crept back to original levels by the eighth day. After the 30 days of ICV, the researchers replaced the cerebrospinal fluid and the mice quickly recovered their weight by eating more food.

To compare leptin's affects via injection and ICV infusion among overweight mice, the researchers selected strains of mice with different types of obesity. One type, the Diet Induced Obese (DIO) mouse, is lean when fed regular mouse chow, but has an inherited predisposition to develop obesity when fed a diet in which 45 percent of the calories are from fat.

The second strain, the New Zeala
'"/>

Contact: Marion E. Glick
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
1-Aug-1997


Page: 1 2 3 4 5

Related biology news :

1. Resistance exercise resets the body clock
2. Insect antibiotics Resistance is futile!
3. Resistance training complements aerobic exercise for women
4. K-State Researchers Study Pest Resistance Management
5. Maggots Could Help Address Problems Of Antibiotic Resistance
6. In The Genes: Extra Belly Fat, Insulin Resistance Linked
7. Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy
8. A "Fossil" Virus Involved In AIDS Drug Resistance?
9. Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers
10. Scientists Locate A Genetic On/Off Switch In Diphtheria; Find May Yield Antibiotics That Wont Boost Bacterial Resistance
11. Local Approaches To Combating Antibiotic Resistance Are Doomed To Failure

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Resistance Leptin Contributes Obesity

(Date:11/18/2014)... WASHINGTON , Nov. 18, 2014  The ... Security Industry Association today jointly announce the formation ... and release of its Identity and Biometric ... (Framework). The Framework received official support from BORDERPOL, ... governments to improve and provide expertise regarding border ...
(Date:11/18/2014)... Md. , Nov. 17, 2014 The Parenteral ... and U.S. regulatory agencies will speak and at least seven ... Metrics Conference at the Omni Shoreham Hotel in ... pleased once again to have significant support from the regulatory ... Europe in our effort to help ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4
(Date:11/18/2014)... November 17, 2014 Athena Signature Series: Turning ... Dr. Beverly Emerson, a professor in the Regulatory Biology Laboratory ... most recent discovery points to an “off switch” for drug ... and how her local research is making a global impact ... findings and then join host Cheryl K. Goodman, CEO of ...
(Date:11/18/2014)... FL (PRWEB) November 18, 2014 Brothers ... announced the launch of PAWSitively Curing Cancer, Inc ... This new 501(c) (3) non-profit organization is dedicated to ... donated goes directly to the University of Florida ... partner with PAWSitively Curing Cancer as the recipient of ...
(Date:11/18/2014)... INCLINE VILLAGE, Nev. , Nov. 18, 2014 /PRNewswire/ ... ) today announced that in connection with the acquisition ... approximately $42.7 million in connection with the termination of ... the full principal amount outstanding of $40 million, accrued ... October 2013, PDL entered into a structured financing transaction ...
(Date:11/18/2014)... 2014  Novira Therapeutics, Inc., a privately held biopharmaceutical ... hepatitis B virus (HBV) infection, today announced that ... Scientific Advisory Board (SAB).  "We are ... Christian S. Schade , Chief Executive Officer of Novira.  ... will be invaluable to Novira as our lead core ...
Breaking Biology Technology:PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 2PAWSitively Curing Cancer, Inc. Launched By Two Children for National Pet Cancer Awareness Month 3PDL BioPharma Announces Successful Conclusion of Debt Financing Agreement with Durata Therapeutics 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 2Novira Therapeutics Announces Appointment of Brian F. Daniels, M.D., to its Scientific Advisory Board 3
Cached News: