HOME >> BIOLOGY >> NEWS
Resistance To Leptin Contributes To Obesity

e increased potency of leptin in lean mice receiving the protein via ICV infusion and those receiving subcutaneous injections shows that the central nervous system, in particular the hypothalamus, is an important site of leptin action," says Friedman. "Indeed, chronic ICV infusions of very low doses of leptin replicate the weight-reducing effects of much higher doses of leptin given by injection. The basis for this apparent difference is not clear, but may suggest that the transport of leptin across the blood-brain barrier, which allows leptin to enter the brain from the body's blood stream, may be an important step in the body's processing of leptin's signal."

Specifically, in normal, lean mice, injecting leptin subcutaneously at an infusion rate of 200 ng per hour, for example, led to an increase in blood levels, from 5 to 7 ng/milliliter, and resulted in a 5 percent reduction in weight. A doubling of leptin levels led to a 9 percent reduction in weight, while a five-fold increase in leptin levels yielded a 15 percent weight loss.

Other lean mice receiving leptin through ICV infusion rapidly lost fat, reaching their lowest weight by the eighth day of treatment and maintained it for the remainder of the 30-day infusion period. The mice reduced their food intake to its lowest level, a drop of more than 50 percent, by the third day, but their food intake crept back to original levels by the eighth day. After the 30 days of ICV, the researchers replaced the cerebrospinal fluid and the mice quickly recovered their weight by eating more food.

To compare leptin's affects via injection and ICV infusion among overweight mice, the researchers selected strains of mice with different types of obesity. One type, the Diet Induced Obese (DIO) mouse, is lean when fed regular mouse chow, but has an inherited predisposition to develop obesity when fed a diet in which 45 percent of the calories are from fat.

The second strain, the New Zeala
'"/>

Contact: Marion E. Glick
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
1-Aug-1997


Page: 1 2 3 4 5

Related biology news :

1. Resistance exercise resets the body clock
2. Insect antibiotics Resistance is futile!
3. Resistance training complements aerobic exercise for women
4. K-State Researchers Study Pest Resistance Management
5. Maggots Could Help Address Problems Of Antibiotic Resistance
6. In The Genes: Extra Belly Fat, Insulin Resistance Linked
7. Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy
8. A "Fossil" Virus Involved In AIDS Drug Resistance?
9. Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers
10. Scientists Locate A Genetic On/Off Switch In Diphtheria; Find May Yield Antibiotics That Wont Boost Bacterial Resistance
11. Local Approaches To Combating Antibiotic Resistance Are Doomed To Failure

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Resistance Leptin Contributes Obesity

(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
(Date:12/17/2014)... Dec. 15, 2014  HITLAB SM announced today its ... confirm its adherence to current U.S. Food and Drug ... regulated smart device and smart phone application trials utilizing ... "HITLAB is determined to improve global healthcare ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is a technology ... measures the overall facial feature of a person such ...
Breaking Biology News(10 mins):23andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
(Date:1/23/2015)... MD (PRWEB) January 23, 2015 Portal ... modern digital workplaces on Microsoft Office 365 and SharePoint ... Future 50 Award program for being one of the region’s ... revenue and employee growth. , “To be recognized a ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... Cambridge Semantics, the leading provider of smart data solutions driven ... record-breaking year across the board for the company. , ... and our Smart Data solutions, our customers were able to ... to record growth for the company in 2014,” said Alok ...
(Date:1/22/2015)... Rootstown, OH (PRWEB) January 22, 2015 Crystal ... announced today that it has received AOAC-PTM Certifications for the ... O111, O121, and O145; collectively referred to as STEC or ... at 1 colony forming unit (cfu) per 325 g of ...
Breaking Biology Technology:Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 2Washington SmartCEO Announces Portal Solutions as 2015 Future 50 Award Winner Second Year in a Row 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Cambridge Semantics Announces Record Results for 2014 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2
Cached News: