Resistance exercise resets the ...( y resistance exercise. They found that ...)

y resistance exercise. They found that Per2 as well as two other clock genes, Cry1 and Bmal1, all increased their expression 6 hours after resistance exercise. In fact the expression levels of many of the genes that normally altered in a 24-hour cycle were affected by the exercise regime. Exercise increased the expression of genes that are normally 'switched off' in the morning, and reduced the expression of genes that are normally 'switched on' in the morning. In effect, exercise caused a phase shift in the expression of the genes, similar to winding on (resetting) the muscle clock.

"Our findings support the idea that peripheral clocks can regulate themselves independently of the clock in the hypothalamus" said Dr. Alex Zambon, Gladstone postdoctoral fellow and the lead author on the study. "If the central clock were responsible for the phase shifting, the same changes in gene expression would have occurred in both the control and exercised legs. While the central clock is still probably involved in the long-term effects of clock phase shifting in peripheral tissue, our evidence suggests that the skeletal muscle clock responds quickly to resistance exercise by regulating the transcription of specific clock genes."

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Contact: Gemma Bradley
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BioMed Central
24-Sep-2003

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