HOME >> BIOLOGY >> NEWS
Respiratory activation in patients with obstructive sleep apnea syndrome (OSA)

Bethesda, MD -- Sleep apnea/hypopnea syndrome is characterized by repetitive upper airway obstruction with ensuing cyclical hypoxia, or a decreased level of oxygen in the blood. Repetitive hypoxia is followed by persistently increased ventilatory motor output, commonly referred to as long-term facilitation (LTF). This excitatory mechanism occurs after repetitive stimulation of the carotid bodies as ventilation returns to baseline over a long duration, up to several hours.

Background

LTF is drawn out by repetitive hypoxia during sleep, but only in those who snore regularly and have evidence of inspiratory (timed during inhalation) flow limitation during sleep. Given the occurrence of repetitive hypoxemia in patients with sleep apnea, researchers set out to investigate the occurrence of LTF in patients with obstructive sleep apnea/hypopnea syndrome (OSA).

A new study tested the hypothesis that episodic hypoxic exposure activates LTF in OSA patients during stable non-rapid eye movement (NREM) sleep. The study was undertaken by inducing repetitive hypoxia in OSA patients using nasal continuous positive airway pressure (CPAP) to maintain upper airway patency and stable sleep state for the duration of the experiments.

The authors of the study, Long-term Facilitation in Obstructive Sleep Apnea Patients During NREM Sleep, are Salah E. Aboubakr, Amy Taylor, Reason Ford, Sarosh Siddiqi, and M. Safwan Badr, all from the Medical Service, John D. Dingell Veterans Affairs Medical Center, and the Division of Pulmonary/Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan. The study is published in the December 2001 edition of the Journal of Applied Physiology.

Methodology

The 11 test subjects selected or this study had recently documented and untreated sleep apnea. Subjects with other medical problems, such as daytime hypoxemia or cor pulmonale (hypertr
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-527-7357
American Physiological Society
10-Jan-2002


Page: 1 2 3 4

Related biology news :

1. Respiratory-pacing device found beneficial in heart failure
2. Respiratory manifestations may be secondary to inflammation in cystic fibrosis patients
3. Common Respiratory Virus Identified As One Cause Of Heart Muscle Damage That Can Lead To Sudden Death
4. Enzyme activation appears key in helping internal clock tell night from day
5. HIV exhausts the immune system through chronic non-specific activation
6. Study suggests new view of gene activation as a dynamic process
7. Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
8. Pancreatic cancer linked to errant reactivation of embryo cell pathway
9. Vitex reports parasite inactivation results at ISBT 2002
10. Folding upon binding: unique protein activation mechanism found by scientists at TSRI
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... first robotic gym for the rehabilitation and functional motor sense evaluation of ... Italy . The first 30 robots will be available from June ... . The technology was developed and patented at the IIT laboratories and ... thanks to a 10 million euro investment from entrepreneur Sergio Dompè. ... ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
(Date:4/24/2017)... , April 24, 2017 Janice ... partner with  Identity Strategy Partners, LLP (IdSP) , ... or without President Trump,s March 6, 2017 ... Entry , refugee vetting can be instilled with greater ... (Right now, all refugee applications are suspended by ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... (PRWEB) , ... June 21, 2017 , ... ... regional office in North Carolina, and engages Timothy Reinhardt to manage the new ... quality leadership at Pfizer Inc, with his most recent role as the Director ...
(Date:6/22/2017)... ... June 22, 2017 , ... Ovation Fertility supports the ... disease, bringing new hope for prospective parents who are challenged with costs of ... the World Health Organization’s designation in hopes of changing the way health insurers, ...
(Date:6/22/2017)... ... 2017 , ... The first human cell line HeLa, established in 1951, has ... cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination and ... and is associated with dramatic consequences for research. , In this educational webinar, ...
(Date:6/20/2017)... ... 20, 2017 , ... CTNext , Connecticut’s go-to resource ... a Higher Education Entrepreneurship Advisory Committee to implement the recommendations of the master ... representatives from 35 higher education institutions across the state over the past six ...
Breaking Biology Technology:
Cached News: