Respiratory activation in patients with obstructive sleep apnea syndrome (OSA)

Bethesda, MD -- Sleep apnea/hypopnea syndrome is characterized by repetitive upper airway obstruction with ensuing cyclical hypoxia, or a decreased level of oxygen in the blood. Repetitive hypoxia is followed by persistently increased ventilatory motor output, commonly referred to as long-term facilitation (LTF). This excitatory mechanism occurs after repetitive stimulation of the carotid bodies as ventilation returns to baseline over a long duration, up to several hours.


LTF is drawn out by repetitive hypoxia during sleep, but only in those who snore regularly and have evidence of inspiratory (timed during inhalation) flow limitation during sleep. Given the occurrence of repetitive hypoxemia in patients with sleep apnea, researchers set out to investigate the occurrence of LTF in patients with obstructive sleep apnea/hypopnea syndrome (OSA).

A new study tested the hypothesis that episodic hypoxic exposure activates LTF in OSA patients during stable non-rapid eye movement (NREM) sleep. The study was undertaken by inducing repetitive hypoxia in OSA patients using nasal continuous positive airway pressure (CPAP) to maintain upper airway patency and stable sleep state for the duration of the experiments.

The authors of the study, Long-term Facilitation in Obstructive Sleep Apnea Patients During NREM Sleep, are Salah E. Aboubakr, Amy Taylor, Reason Ford, Sarosh Siddiqi, and M. Safwan Badr, all from the Medical Service, John D. Dingell Veterans Affairs Medical Center, and the Division of Pulmonary/Critical Care and Sleep Medicine, Department of Medicine, Wayne State University School of Medicine, Detroit, Michigan. The study is published in the December 2001 edition of the Journal of Applied Physiology.


The 11 test subjects selected or this study had recently documented and untreated sleep apnea. Subjects with other medical problems, such as daytime hypoxemia or cor pulmonale (hypertr

Contact: Donna Krupa
American Physiological Society

Page: 1 2 3 4

Related biology news :

1. Respiratory-pacing device found beneficial in heart failure
2. Respiratory manifestations may be secondary to inflammation in cystic fibrosis patients
3. Common Respiratory Virus Identified As One Cause Of Heart Muscle Damage That Can Lead To Sudden Death
4. Enzyme activation appears key in helping internal clock tell night from day
5. HIV exhausts the immune system through chronic non-specific activation
6. Study suggests new view of gene activation as a dynamic process
7. Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
8. Pancreatic cancer linked to errant reactivation of embryo cell pathway
9. Vitex reports parasite inactivation results at ISBT 2002
10. Folding upon binding: unique protein activation mechanism found by scientists at TSRI
11. Findings link disease specific anitbodies to activation of T cells for the first time

Post Your Comments:

(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... ... of medical marijuana products targeting the needs of consumers who are incorporating medical ... takes place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments is ... Nanoscience Analytical offers a broad range of contract analysis services for advanced ...
(Date:10/7/2017)... Mass. , Oct. 6, 2017  The ... work of three scientists, Jacques Dubochet, Joachim ... breakthrough developments in cryo-electron microscopy (cryo-EM) ... technology within the structural biology community. The winners ... Scientists can now routinely produce highly resolved, three-dimensional ...
(Date:10/6/2017)... (PRWEB) , ... October 06, 2017 , ... ... host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial ... Investigator, Dana-Farber Cancer Institute. The event is free and open to the public, ...
Breaking Biology Technology:
Cached News: