Results Of Poisoning Visible In Urine

Toxic substances present in the environment or resulting from the use of medication release chemical compounds which can quickly react with human tissue, thereby causing damage. Up to now, it was not easy to identify this damage at an early stage. Recently, however, toxicologists at Amsterdam Vrije Universiteit have discovered substances formed during this reaction of free radicals with the tissue which are excreted in the urine within only a few days. This discovery has made it easier to determine the damaging effects of chemotherapy in cancer patients, and to do so at an earlier stage. The research was funded by the NWO's Technology Foundation (STW).

The toxicologists carried out tests on rats to see whether the presence of such substances as acetone and aldehydes indicates damage caused by free radicals. These substances are created when free radicals react with lipids in the membranes of cells. The body thinks they are waste products and excretes them in the urine. The rats received doses of toxic chemicals which led to free radicals being released in the kidneys or the liver. Higher doses of these toxic chemicals mean increased excretion of acetone and aldehydes. The concentrations of these substances in the urine give an earlier indication of the damage caused by the free radicals than can be done using other techniques.

The toxicologists then examined whether acetone or aldehydes can also be used as indicators of physical damage in patients receiving chemotherapy for cancer. Chemotherapy makes use of a variety of substances including cytostatics, which may result in the production of free radicals in the body. Depending on the type of chemotherapy, the amount of acetone and aldehydes excreted during the first three days after treatment was between two and twelve times higher than normal. By administering anti-oxidants, it was possible to restrict excretion of these products. Anti-oxidants react with the free radicals, making them harmless to the b

Contact: Dr. Loeckie de Zwart
Netherlands Organization for Scientific Research

Page: 1 2

Related biology news :

1. Results of pivotal study for GlaxoSmithKlines Valtrex published in New England Journal of Medicine
2. Results from open-label Raptiva study suggest continued benefit with long-term treatment
3. NASA Materials Conference Features Science Results, Experts on Technologies for Exploration
4. Abgenix Reports Encouraging Preclinical Results With ABX-EGF In Cancer Research
5. Encouraging Results In Preclinical Studies Of Parkinsons Disease Gene Therapy
6. Quicker Implementation Of Research Results
7. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
8. New Gene Therapy Technique Results In Efficient Gene Delivery
9. False Security: You Cant Always Believe The Results Of A Genetic Test
10. Cell Pathways Reports Extension Study Results Showing Ability Of FGN-1 To Prevent Formation Of Precancerous Colon Polyps
11. Results Of Hog-Stress Study May Lead To Better Management Methods

Post Your Comments:

(Date:5/14/2019)... ... May 13, 2019 , ... NRD, LLC is excited ... on May 15-16, 2019, the largest medical technology event in the Northeast serving ... embedded systems product organizations. , They will be displaying their latest technologies, including ...
(Date:5/8/2019)... ... May 08, 2019 , ... RG+A, Inc., ... Carol S. Mann has agreed to serve as Chief Executive Officer and pharmaceutical ... Officer, effective immediately. They will join Chairman and Founder Roger Green to create ...
(Date:5/8/2019)... ... May 08, 2019 , ... ... diameter of 200 microns and a lead-in fiber of 100 microns. With dimensions ... standard and positioning itself as the world leader in the development of fiber ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... ... the Diopsys® ffERG/Photopic Negative Response vision test, a new full field ... it is estimated that 6.3 million Americans will have glaucoma, with black Americans ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... will present results documenting discrepancies between U.S. insurer policies for genetic testing and ... risk for hereditary breast and ovarian cancer (HBOC). , Jill S. ...
(Date:4/18/2019)... ... April 18, 2019 , ... Taking a step closer ... chemical engineer at Worcester Polytechnic Institute (WPI) has developed a novel process using ... manufacture isobutanol and other biofuels more economically. , Isobutanol, like ethanol, is an ...
(Date:4/12/2019)... ... April 12, 2019 , ... ... neurotechnology and will educate about innovative tools and devices being used to enhance ... for more information. , This segment of Advancements will focus on Sound for ...
Breaking Biology Technology:
Cached News: