HOME >> BIOLOGY >> NEWS
Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases

A group from the Salk institute illuminates the structural basis for tetraketide cyclization in stilbene synthase, the enzyme that produces resveratrol, the beneficial phytonutrient found in red wine.

Plant natural products called stilbenes can confer antifungal resistance to host plants and have been shown to possess health benefits for humans and other animals when present in their diet. The best known stilbene is resveratrol, which is found in grapes and is believed to be a major contributor to the "French Paradox," which refers to the health benefits associated with the moderate consumption of red wine. The mechanism of stilbene synthesis is therefore of great pharmaceutical and medical interest. Much is already understood about the enzymatic features of type III polyketide synthases, the enzyme family that generates stilbenes, but until now one mystery remained: How are stilbene synthases regulated to conduct the specific cyclization reaction required to produce stilbenes? For example, stilbene synthase (STS) and chalcone synthase (CHS) share 75%90% amino acid sequence identity and generate the same tetraketide, but STS enzymes cyclize this tetraketide via an intramolecular C2 to C7 aldol condensation to make stilbene, whereas the CHS cyclize via C2 to C6 condensation reaction to make chalcone. A group of researchers led by Joseph Noel at the Salk Institute has revealed the structural basis for the specificity of this critical reaction. To do this, the Noel group generated the first crystal structure of a STS and identified how STS evolved from its CHS ancestor by comparing the two at the structural and molecular levels. To prove their hypothesis, the Noel group used this information to convert alfalfa CHS into a functional STS by structure-guided engineering. Their work reveals an unexpected mechanism for functional divergence of the STS from the CHS. Specificity of cyclization is not regulated by the shape of the active site, as was believed prev
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
17-Sep-2004


Page: 1 2

Related biology news :

1. Genes can influence both alcohol consumption and dependence
2. Genes may be central to cocaine addiction
3. Genes appear to play a role in development of chronic obstructive pulmonary disease
4. Genes make the marsh
5. Genes predict response of adult leukemia patients to chemotherapy
6. Genes influence memory in families with Alzheimers disease
7. Genes control severity of heart failure, study finds
8. Genes that regulate hearing link humans and fruit flies in new way
9. Genes discovered that regulate blood stem cell development
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
(Date:4/15/2014)... are many viral diseases in the world for which ... fever, which is spread by mosquitoes in the tropics, ... more familiar in Finland and is easily spread by ... children and the elderly. , Researchers at Aalto University ... in preliminary tests to prevent the spread of one ...
(Date:4/15/2014)... parasites of cuttlefish, squid and octopus has uncovered ... shown how they may help in investigating populations ... has described 10 new parasite species− dicyemid mesozoans ... (cuttlefish, squid and octopus). They are the ... Australian waters. , "Although dicyemid parasites have ...
(Date:4/15/2014)... 15, 2014) New research published in the ... American College of Nutrition shows whey protein, either ... part of a weight-loss or weight-maintenance diet, may provide ... , The meta-analysis included 14 randomized controlled trials with ... those weight loss studies that used whey protein to ...
Breaking Biology News(10 mins):Nanocrystalline cellulose modified into an efficient viral inhibitor 2Bizarre parasite may provide cuttlefish clues 2New meta-analysis builds on the power of whey protein for improved body composition 2New meta-analysis builds on the power of whey protein for improved body composition 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
Cached News: