HOME >> BIOLOGY >> NEWS
Resveratrol synthase uncovered: Cyclization specificity of type III polyketide synthases

A group from the Salk institute illuminates the structural basis for tetraketide cyclization in stilbene synthase, the enzyme that produces resveratrol, the beneficial phytonutrient found in red wine.

Plant natural products called stilbenes can confer antifungal resistance to host plants and have been shown to possess health benefits for humans and other animals when present in their diet. The best known stilbene is resveratrol, which is found in grapes and is believed to be a major contributor to the "French Paradox," which refers to the health benefits associated with the moderate consumption of red wine. The mechanism of stilbene synthesis is therefore of great pharmaceutical and medical interest. Much is already understood about the enzymatic features of type III polyketide synthases, the enzyme family that generates stilbenes, but until now one mystery remained: How are stilbene synthases regulated to conduct the specific cyclization reaction required to produce stilbenes? For example, stilbene synthase (STS) and chalcone synthase (CHS) share 75%90% amino acid sequence identity and generate the same tetraketide, but STS enzymes cyclize this tetraketide via an intramolecular C2 to C7 aldol condensation to make stilbene, whereas the CHS cyclize via C2 to C6 condensation reaction to make chalcone. A group of researchers led by Joseph Noel at the Salk Institute has revealed the structural basis for the specificity of this critical reaction. To do this, the Noel group generated the first crystal structure of a STS and identified how STS evolved from its CHS ancestor by comparing the two at the structural and molecular levels. To prove their hypothesis, the Noel group used this information to convert alfalfa CHS into a functional STS by structure-guided engineering. Their work reveals an unexpected mechanism for functional divergence of the STS from the CHS. Specificity of cyclization is not regulated by the shape of the active site, as was believed prev
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
17-Sep-2004


Page: 1 2

Related biology news :

1. Genes can influence both alcohol consumption and dependence
2. Genes may be central to cocaine addiction
3. Genes appear to play a role in development of chronic obstructive pulmonary disease
4. Genes make the marsh
5. Genes predict response of adult leukemia patients to chemotherapy
6. Genes influence memory in families with Alzheimers disease
7. Genes control severity of heart failure, study finds
8. Genes that regulate hearing link humans and fruit flies in new way
9. Genes discovered that regulate blood stem cell development
10. Genes that paint fly derrieres hint at convergence
11. Genes, Brain and Behavior Symposium April 16

Post Your Comments:
(Date:8/17/2015)... , Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market ... new sales campaign for Q4 2015. The new marketing ... team consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) ... Group is a leader in retail driven marketing and ...
(Date:8/12/2015)... 12, 2015 As the digital ... innovation and advanced biometrics technology is accelerating beyond expectations.  ... rely on using their credit cards, the digital currency, ... for payment services led by companies in the space ... Google, Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ...
(Date:8/12/2015)... 12, 2015  Synaptics Inc. (NASDAQ: SYNA ... today announced that four of its fingerprint ID ... officially been named FIDO Certified™ by the Fast ... certification, Synaptics, Natural ID™ fingerprint solutions are fully ... (UAF) standard and are interoperable among other products ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
(Date:9/3/2015)... , Sept. 3, 2015 /PRNewswire/ - bioLytical Laboratories ... to announce its study " Sensitivity of a rapid ... is enhanced by its affinity for HIV gp41 IgM ... Clinical Virology.  This study highlights INSTI,s ability to detect ... their findings at the 8 th annual International ...
(Date:9/3/2015)... ... 03, 2015 , ... If you plan to attend the 27th annual ... also want to sign up for the tour of Framingham State University's newest addition ... walk through of the (8) chemistry teaching labs that are exclusively utilizing (49) ...
(Date:9/2/2015)... DUBLIN , Sep. 02, 2015 ... ) has announced the addition of Jain PharmaBiotech,s ... Markets and Companies" to their offering. ... markets based on technologies and applications. The report ... basis for estimation of markets. Technologies include array ...
(Date:9/2/2015)... Biovista Inc. is glad to ... BeHEARD science challenge, a global competition hosted by the ... to the latest life science innovations and technologies. ... analytics capability to support Steven Laffoon and ... of Niemann-Pick Disease Type A (NPA), a rare and ...
Breaking Biology Technology:bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 2bioLytical's INSTI HIV Test Detects gp41 specific IgM Antibodies 3Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2
Cached News: