Revised guidelines published for testing for hereditary type of colorectal cancer

An international group of experts has updated a set of criteria for testing patients with colorectal cancer to determine whether the cancer is a specific type that is inherited and therefore may mean that a patient's family members are at an increased risk of the disease. The revised Bethesda Guidelines are published in the February 18 issue of the Journal of the National Cancer Institute.

Hereditary nonpolyposis colorectal cancer (HNPCC) usually occurs in patients younger than age 45 and can result in the development of cancers in a variety of tissues, such as the colon, rectum, endometrium, stomach, ovaries, brain, and skin. A major genetic characteristic of HNPCC tumors is microsatellite instability (MSI). Microsatellites are short repeated sequences of DNA, and MSI results when mutations in genes that are responsible for repairing damaged DNA cause microsatellites to become longer or shorter. Cancers that exhibit MSI account for about 15% of all colorectal cancers.

Because HNPCC results from inherited mutations, it is possible that family members of patients with HNPCC also have the genetic characteristics that put them at an increased risk for cancers associated with a particular mutation. In 1997, a panel of experts created the Bethesda Guidelines, which outlined criteria for testing tumors from patients with colorectal cancer for MSI so scientists can better understand the development process of HNPCC and identify patients with the syndrome. Such testing would also allow affected family members to take measures to reduce their risk of developing HNPCC-associated cancers.

In a commentary, Asad Umar, D.V.M., Ph.D., of the National Cancer Institute, and colleagues summarize a meeting in 2002 at which experts looked at the most recent evidence about HNPCC gene mutations and revised the Bethesda Guidelines for testing colorectal tumors for MSI. The revised criteria suggest that tumors from patients with colorectal cancer should be tested f

Contact: Katherine Arnold
Journal of the National Cancer Institute

Page: 1 2

Related biology news :

1. Revised model of protein-drug interactions could make job of drug designers a little easier
2. New guidelines show significant benefits of FUZEON for wide range of pre-treated HIV/AIDS patients
3. International critical care doctors release first-ever guidelines for sepsis
4. New ACOG guidelines on progesterone to prevent preterm birth praised by March of Dimes
5. Ethical guidelines needed before nutrigenomic groceries come to market
6. New guidelines can help health officials better predict and control dengue epidemics
7. Researchers develop guidelines to establish identity of genes responsible for complex diseases
8. Aborigine study suggests body mass index guidelines should be lower to block diabetes
9. New nutrition guidelines for diabetics promote emphasis on high-monounsaturated fat diet
10. Conservation International and Starbucks announce new coffee sourcing guidelines
11. Report on dietary supplements containing ephedra makes urgent call for research to develop dose guidelines, safety warnings

Post Your Comments:

(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/18/2017)... April 18, 2017  Socionext Inc., a global expert in SoC-based ... edge server, the M820, which features the company,s hybrid codec technology. ... by Tera Probe, Inc., will be showcased during the upcoming Medtec ... show at the Las Vegas Convention Center ... Click here ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... ... of medical marijuana products targeting the needs of consumers who are incorporating medical ... takes place in Phoenix, Arizona. , As operators of two successful Valley dispensaries, ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... instruments and applications consulting for microscopy and surface analysis, Nanoscience Instruments is ... Nanoscience Analytical offers a broad range of contract analysis services for advanced ...
(Date:10/7/2017)... Mass. , Oct. 6, 2017  The ... work of three scientists, Jacques Dubochet, Joachim ... breakthrough developments in cryo-electron microscopy (cryo-EM) ... technology within the structural biology community. The winners ... Scientists can now routinely produce highly resolved, three-dimensional ...
(Date:10/6/2017)... (PRWEB) , ... October 06, 2017 , ... ... host a lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial ... Investigator, Dana-Farber Cancer Institute. The event is free and open to the public, ...
Breaking Biology Technology:
Cached News: