HOME >> BIOLOGY >> NEWS
Revised guidelines published for testing for hereditary type of colorectal cancer

An international group of experts has updated a set of criteria for testing patients with colorectal cancer to determine whether the cancer is a specific type that is inherited and therefore may mean that a patient's family members are at an increased risk of the disease. The revised Bethesda Guidelines are published in the February 18 issue of the Journal of the National Cancer Institute.

Hereditary nonpolyposis colorectal cancer (HNPCC) usually occurs in patients younger than age 45 and can result in the development of cancers in a variety of tissues, such as the colon, rectum, endometrium, stomach, ovaries, brain, and skin. A major genetic characteristic of HNPCC tumors is microsatellite instability (MSI). Microsatellites are short repeated sequences of DNA, and MSI results when mutations in genes that are responsible for repairing damaged DNA cause microsatellites to become longer or shorter. Cancers that exhibit MSI account for about 15% of all colorectal cancers.

Because HNPCC results from inherited mutations, it is possible that family members of patients with HNPCC also have the genetic characteristics that put them at an increased risk for cancers associated with a particular mutation. In 1997, a panel of experts created the Bethesda Guidelines, which outlined criteria for testing tumors from patients with colorectal cancer for MSI so scientists can better understand the development process of HNPCC and identify patients with the syndrome. Such testing would also allow affected family members to take measures to reduce their risk of developing HNPCC-associated cancers.

In a commentary, Asad Umar, D.V.M., Ph.D., of the National Cancer Institute, and colleagues summarize a meeting in 2002 at which experts looked at the most recent evidence about HNPCC gene mutations and revised the Bethesda Guidelines for testing colorectal tumors for MSI. The revised criteria suggest that tumors from patients with colorectal cancer should be tested f
'"/>

Contact: Katherine Arnold
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
17-Feb-2004


Page: 1 2

Related biology news :

1. Revised model of protein-drug interactions could make job of drug designers a little easier
2. New guidelines show significant benefits of FUZEON for wide range of pre-treated HIV/AIDS patients
3. International critical care doctors release first-ever guidelines for sepsis
4. New ACOG guidelines on progesterone to prevent preterm birth praised by March of Dimes
5. Ethical guidelines needed before nutrigenomic groceries come to market
6. New guidelines can help health officials better predict and control dengue epidemics
7. Researchers develop guidelines to establish identity of genes responsible for complex diseases
8. Aborigine study suggests body mass index guidelines should be lower to block diabetes
9. New nutrition guidelines for diabetics promote emphasis on high-monounsaturated fat diet
10. Conservation International and Starbucks announce new coffee sourcing guidelines
11. Report on dietary supplements containing ephedra makes urgent call for research to develop dose guidelines, safety warnings

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2020)... ... April 27, 2020 , ... ... was started by three teenagers with an idea to help millions of people ... the time of great need and suffering, an outlet has been created for ...
(Date:4/22/2020)... ... April 20, 2020 , ... RCH Solutions (RCH ), a global ... announces the hiring of Michael Wlodarczyk as Director of Sales and Business Development. Based ... grow the company’s already strong presence across the Northeast. , “We continue to see ...
(Date:4/18/2020)... ... April 16, 2020 , ... SIRION Biotech GmbH , a world ... it will present a company update on its work expediting gene therapy research and ... on April 22 and 23. Dieter Lingelbach, the Company’s Chief Operating Officer, will also ...
Breaking Biology News(10 mins):
(Date:4/26/2020)... ... April 23, 2020 , ... Indegene Omnipresence, Inc. ... providing applications and services for use on Microsoft Azure. The customer experience management ... up online for a built-for-purpose customer engagement capability to use in their commercial ...
(Date:4/22/2020)... and CAMBRIDGE, Mass. (PRWEB) , ... April 20, ... ... Budapest with US offices in Cambridge, MA, announced today that Omixon’s founder and ... the early commercialisation of Omixon’s flagship product Holotype HLA since 2014 before stepping ...
(Date:4/22/2020)... ... April 21, 2020 , ... ... work through COVID-19. Many clinical trial teams are working remotely and have paused ... wants to help researchers continue their research during this uncertain time by giving ...
(Date:4/7/2020)... ... April 06, 2020 , ... Gateway Genomics , leading developer ... SneakPeek Early Gender DNA Tests sold in March, just months after attaining ... an ecommerce product, where a mom could order her kit online, collect a DNA ...
Breaking Biology Technology:
Cached News: