HOME >> BIOLOGY >> NEWS
Revised guidelines published for testing for hereditary type of colorectal cancer

An international group of experts has updated a set of criteria for testing patients with colorectal cancer to determine whether the cancer is a specific type that is inherited and therefore may mean that a patient's family members are at an increased risk of the disease. The revised Bethesda Guidelines are published in the February 18 issue of the Journal of the National Cancer Institute.

Hereditary nonpolyposis colorectal cancer (HNPCC) usually occurs in patients younger than age 45 and can result in the development of cancers in a variety of tissues, such as the colon, rectum, endometrium, stomach, ovaries, brain, and skin. A major genetic characteristic of HNPCC tumors is microsatellite instability (MSI). Microsatellites are short repeated sequences of DNA, and MSI results when mutations in genes that are responsible for repairing damaged DNA cause microsatellites to become longer or shorter. Cancers that exhibit MSI account for about 15% of all colorectal cancers.

Because HNPCC results from inherited mutations, it is possible that family members of patients with HNPCC also have the genetic characteristics that put them at an increased risk for cancers associated with a particular mutation. In 1997, a panel of experts created the Bethesda Guidelines, which outlined criteria for testing tumors from patients with colorectal cancer for MSI so scientists can better understand the development process of HNPCC and identify patients with the syndrome. Such testing would also allow affected family members to take measures to reduce their risk of developing HNPCC-associated cancers.

In a commentary, Asad Umar, D.V.M., Ph.D., of the National Cancer Institute, and colleagues summarize a meeting in 2002 at which experts looked at the most recent evidence about HNPCC gene mutations and revised the Bethesda Guidelines for testing colorectal tumors for MSI. The revised criteria suggest that tumors from patients with colorectal cancer should be tested f
'"/>

Contact: Katherine Arnold
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
17-Feb-2004


Page: 1 2

Related biology news :

1. Revised model of protein-drug interactions could make job of drug designers a little easier
2. New guidelines show significant benefits of FUZEON for wide range of pre-treated HIV/AIDS patients
3. International critical care doctors release first-ever guidelines for sepsis
4. New ACOG guidelines on progesterone to prevent preterm birth praised by March of Dimes
5. Ethical guidelines needed before nutrigenomic groceries come to market
6. New guidelines can help health officials better predict and control dengue epidemics
7. Researchers develop guidelines to establish identity of genes responsible for complex diseases
8. Aborigine study suggests body mass index guidelines should be lower to block diabetes
9. New nutrition guidelines for diabetics promote emphasis on high-monounsaturated fat diet
10. Conservation International and Starbucks announce new coffee sourcing guidelines
11. Report on dietary supplements containing ephedra makes urgent call for research to develop dose guidelines, safety warnings

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... May 16, 2017  Veratad Technologies, LLC ( www.veratad.com ... age and identity verification solutions, announced today they will ... 2017, May 15 thru May 17, 2017, in ... International Trade Center. Identity impacts the ... in today,s quickly evolving digital world, defining identity is ...
(Date:4/19/2017)... ALBANY, New York , April 19, 2017 /PRNewswire/ ... highly competitive, as its vendor landscape is marked by ... in the market is however held by five major ... and Safran. Together these companies accounted for nearly 61% ... majority of the leading companies in the global military ...
(Date:4/13/2017)... India , April 13, 2017 According to ... Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, ... MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 Billion ... Growth Rate (CAGR) of 17.3%. ... MarketsandMarkets ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... , ... October 11, 2017 , ... ... gene in its endogenous context, enabling overexpression experiments and avoiding the use of ... small RNA guides is transformative for performing systematic gain-of-function studies. , This ...
(Date:10/11/2017)... CA, USA (PRWEB) , ... October 11, 2017 , ... ... to take place on 7th and 8th June 2018 in San Francisco, CA. The ... influencers as well as several distinguished CEOs, board directors and government officials from around ...
(Date:10/11/2017)... BioMarketing, a leading provider of patient support solutions, has announced ... network, which will launch this week. The VMS CNEs will ... to enhance the patient care experience by delivering peer-to-peer education ... professionals to help women who have been diagnosed and are ... ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... Disappearing forests ... the lives of over 5.5 million people each year. Especially those living in larger ... startup Treepex - based in one of the most pollution-affected countries globally - decided ...
Breaking Biology Technology:
Cached News: