HOME >> BIOLOGY >> NEWS
Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness

GAINESVILLE---University of Florida researchers have designed a new genetic weapon that can--in laboratory animals--significantly slow progression of retinitis pigmentosa, a leading cause of inherited human blindness.

The weapon, a ribozyme manufactured in the laboratory, works by chopping up genetic messengers before they deliver the instructions of a mutant gene.

"This is the first case we know of where ribozymes have been used to correct a disease in an animal in a way that realistically could be used in humans," said Alfred S. Lewin, a professor of molecular genetics and microbiology in UF's College of Medicine. "We also believe this technique might be useful for other inherited diseases."

Lewin and William Hauswirth, a professor with dual appointments in ophthalmology, as well as molecular genetics and microbiology, are leading a team conducting further animal studies in preparation for human clinical trials, an estimated five years away.

About 1 in 3,000 Americans has retinitis pigmentosa, a degenerative disease whose symptoms generally first appear during adolescence. As the disorder progresses, night vision, peripheral vision and ultimately all sight can be lost. Currently, there is no way to halt the deterioration.

Since the UF research was published in the August issue of Nature Medicine, Lewin has heard from many other scientists who are working to apply "ribozyme rescue" to heart disease, neurological disorders and viral diseases.

"UF's work is a great example of how fundamental research, whose goal is to understand basic cellular processes, can lead to important advances that have a direct impact on human health," said John Burke, a professor of microbiology and molecular genetics at the University of Vermont.

UF's research builds on the Nobel Prize-winning discovery in other laboratories that ribonucleic acid, or RNA, can act as an enzyme, a substance that causes chemical reactions within cells. It is then known as a ri
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
9-Oct-1998


Page: 1 2 3

Related biology news :

1. Ribozymes Come Ready For Action
2. Interdisciplinary Method Offers New Way To Study Ribozymes
3. 1st International Conference on Cell Therapy for Cardiovascular Disease
4. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
5. Braunschweig Prize 2003 for Molecular Cancer Therapy
6. Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
7. New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
8. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
9. Invitation To Cover: American Society Of Gene Therapy Meeting
10. Gene Therapy For Pain
11. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/4/2019)... ... June 04, 2019 , ... Molecular Devices, ... Susan Murphy as the new President of Molecular Devices, replacing Greg Milosevich who ... company, Danaher Corporation. , Since joining Molecular Devices in a scientific engineering role, ...
(Date:6/4/2019)... , ... June 04, 2019 , ... Lajollacooks4u is delighted ... recipients. The recognition, which honors hospitality excellence, is given only to businesses that have ... Excellence for five consecutive years. , To qualify for the Certificate of ...
(Date:5/31/2019)... ... May 29, 2019 , ... FileWave, the ... mobile, announces the launch of version 13.1. The new version extends FileWave’s mobile ... and supports Apple’s spring release functionality. Version 13.1 builds on FileWave’s version 13 ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... ... 15, 2019 , ... Milton Hershey School® has named William Charles Ballough Harding ... biomedical industry, where he is changing lives by creating solutions to global healthcare challenges ... the vision of our founders – Milton and Catherine Hershey – who always hoped ...
(Date:5/8/2019)... ... May 07, 2019 , ... Standing at 16.2 hands, Atlas is on the large side for ... team and barrel racing, among other activities. When loping around a corner in late ... being a busy horse to only being able to walk. Fortunately Atlas’ owner, Kelly, ...
(Date:5/2/2019)... (PRWEB) , ... April 30, ... ... the International Organization for Standardization ISO 9001:2015 standard, REPROCELL USA Inc. has ... customer requirements. In addition, REPROCELL USA Inc. aims to enhance customer satisfaction ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... in the greater Boston area. Gone are the days of painful hair transplant ... Robotic Hair Restoration System is the only robotic intelligent solution to offer a ...
Breaking Biology Technology:
Cached News: