HOME >> BIOLOGY >> NEWS
Ribozymes To The Rescue: New UF Gene Therapy Shows Promise For Treatment Of Inherited Blindness

GAINESVILLE---University of Florida researchers have designed a new genetic weapon that can--in laboratory animals--significantly slow progression of retinitis pigmentosa, a leading cause of inherited human blindness.

The weapon, a ribozyme manufactured in the laboratory, works by chopping up genetic messengers before they deliver the instructions of a mutant gene.

"This is the first case we know of where ribozymes have been used to correct a disease in an animal in a way that realistically could be used in humans," said Alfred S. Lewin, a professor of molecular genetics and microbiology in UF's College of Medicine. "We also believe this technique might be useful for other inherited diseases."

Lewin and William Hauswirth, a professor with dual appointments in ophthalmology, as well as molecular genetics and microbiology, are leading a team conducting further animal studies in preparation for human clinical trials, an estimated five years away.

About 1 in 3,000 Americans has retinitis pigmentosa, a degenerative disease whose symptoms generally first appear during adolescence. As the disorder progresses, night vision, peripheral vision and ultimately all sight can be lost. Currently, there is no way to halt the deterioration.

Since the UF research was published in the August issue of Nature Medicine, Lewin has heard from many other scientists who are working to apply "ribozyme rescue" to heart disease, neurological disorders and viral diseases.

"UF's work is a great example of how fundamental research, whose goal is to understand basic cellular processes, can lead to important advances that have a direct impact on human health," said John Burke, a professor of microbiology and molecular genetics at the University of Vermont.

UF's research builds on the Nobel Prize-winning discovery in other laboratories that ribonucleic acid, or RNA, can act as an enzyme, a substance that causes chemical reactions within cells. It is then known as a ri
'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
9-Oct-1998


Page: 1 2 3

Related biology news :

1. Ribozymes Come Ready For Action
2. Interdisciplinary Method Offers New Way To Study Ribozymes
3. 1st International Conference on Cell Therapy for Cardiovascular Disease
4. National Cancer Gene Therapy Foundation gives $4.0 million in research grants
5. Braunschweig Prize 2003 for Molecular Cancer Therapy
6. Alliance for Cancer Gene Therapy announces $1.5 million in national grants to young investigators
7. New research on safety of intracoronary delivery of adenovector reported in cover story of Molecular Therapy
8. Therapy hinders AIDS virus from evolving drug resistance, Hopkins researchers find
9. Invitation To Cover: American Society Of Gene Therapy Meeting
10. Gene Therapy For Pain
11. Role Of Protein Linked To Colon Cancer Identified, Offering Potential Target For Therapy

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/24/2017)... Research and Markets has announced the addition ... Trends - Industry Forecast to 2025" report to their offering. ... The Global Biometric ... of around 15.1% over the next decade to reach approximately $1,580 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 ... ... introduce the Fluidnatek® Electrospinning and Electrospraying line of ... scales from table-top equipment for the lab to fully automated pilot plants ...
(Date:8/16/2017)... , ... August 16, 2017 , ... While art and ... much more closely connected than one might think. A Mesh Is Also a ... at the University City Science Center’s Esther Klein Gallery (EKG) on August 17 and ...
(Date:8/16/2017)... ... August 16, 2017 , ... We are proud to ... inspection at our Dilworth, MN site. The inspection took place Monday, July 31st ... as part of a routine Bioresearch Monitoring Program (BIMO) with the USFDA wherein ...
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017  Kingfisher Talent, ... search and leadership development, and Virdis Group, global executive search ... exclusive alliance that enables clients to leverage the expertise and ... "For our clients here in the Boston ... diverse population of leadership talent throughout the US, ...
Breaking Biology Technology:
Cached News: