HOME >> BIOLOGY >> NEWS
Rice bioengineers develop method to grow 3-D bone matrix

HOUSTON-- Oct. 3, 2002 -- A new study by Rice University researchers indicates that bioengineers growing bone in the laboratory may be able to create the mechanical stimulation needed to grow bone outside the body.

One of the greatest challenges tissue engineers face in growing bone in the laboratory is recreating the conditions that occur inside the body. The recipe for growing healthy bones includes not only a precise biological mix -- bone cells called "osteoblasts" and several growth factors that osteoblasts use to build the mineralized matrix of bones -- but also mechanical stimulation. Astronauts whose bones become brittle after months in orbit are a testament to the importance that mechanical stress plays in bone growth. In orbit, their skeletons aren't subject to the everyday stresses of gravity.

Tissue engineers at Rice placed bone marrow-derived osteoblasts from rats into centimeter-wide plexiglass chambers containing a thin stack of titanium fiber mesh. The samples were covered with a liquid growth medium -- a bath of chemicals that promotes bone growth -- and sealed in an incubator. After letting the cultures sit overnight -- to give the cells time to attach themselves to the mesh -- engineers pumped growth medium through the cultures for 16 days. Bone cultures were subjected to a range of three different flow rates to provide mechanical stimulation, and another set of cultures were grown in a motionless bath.

Results of the research appear in the current issue of the Proceedings of the National Academy of Sciences USA.

"Researchers have used fluid flow to stimulate bone growth before, but no one has looked at its effect on three-dimensional cultures that have been subjected to continuous stimulation for several days," said Tony Mikos, the John W. Cox Professor of Bioengineering. "We found that even the lowest flow rate produced a significant increase in the formation of mineralized bone. Moreover, the miner
'"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
3-Oct-2002


Page: 1 2

Related biology news :

1. UCSD bioengineers develop first genome-scale computational model of gene regulation
2. Dartmouth bioengineers develop humanized yeast
3. Tufts University bioengineers discover secret of spider, silkworm fiber strength
4. UCSD bioengineers use computer model to predict evolution of bacteria
5. UCSD bioengineers develop first computer model that predicts disease variant based on genetic defect
6. Possible cause and treatment for shock uncovered by UC San Diego bioengineers
7. NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
8. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
9. Wisconsin scientists develop quick botox test
10. Bronfenbrenner book sums up human development
11. Researchers develop fast track way to discover how cells are regulated

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Rice bioengineers develop method grow bone matrix

(Date:4/20/2015)... The announcement comes as demand for fire ... Ireland,s foremost records management company, has ... an impressive track record of clients within the first 12 ... management sector in Dubai . As a ... employ a further eight staff members at its Irish headquarters. ...
(Date:4/14/2015)... 2015  HYPR Corp. today announced it has ... Alliance tm , an industry consortium transforming online ... share technology and collaborate to deliver open specifications ... secure and private, and easier to use. ... protects sensitive user information and eliminates the dependency ...
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
(Date:5/26/2015)... Pharmaco-Kinesis Corporation (PKC) announced today that its ... on the Beach in Santa Monica, CA ... Company,s innovative Metronomic Biofeedback Pump (MBP), a fully smart ... time to a target site of the human body ... in real-time.  ...
(Date:5/26/2015)... JERUSALEM , May 26, 2015 ... http://www.oramed.com ), a clinical-stage pharmaceutical company focused on the ... it has submitted the study protocol for the company,s ... to the U.S. Food and Drug Administration (FDA). The ... Drug (IND) application. The Phase IIb study ...
(Date:5/26/2015)... Just the characterization of being a new breakthrough ... not guarantee immediate acceptance. In particular, a new ... failures is often met with significant skepticism. The ... that is often an unappreciated aspect of scientific innovation. ... has found that building acceptance of its new ...
(Date:5/22/2015)... , May 22, 2015  Actavis plc (NYSE: ... U.S. Court of Appeals for the Second Circuit has ... injunction requiring the Company to continue distribution of NAMENDA ... - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO   "While we ... ruling, we intend to continue our strong efforts to ...
Breaking Biology Technology:Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 2Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 3Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 4Pharmaco-Kinesis Corporation Convenes Third Neuro-Oncology Clinical Advisory Board Meeting 5Oramed Submits Protocol to U.S. FDA for Its Phase IIb Oral Insulin Study 2Oramed Submits Protocol to U.S. FDA for Its Phase IIb Oral Insulin Study 3In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 2In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8
Cached News: