HOME >> BIOLOGY >> NEWS
Rice bioengineers develop method to grow 3-D bone matrix

HOUSTON-- Oct. 3, 2002 -- A new study by Rice University researchers indicates that bioengineers growing bone in the laboratory may be able to create the mechanical stimulation needed to grow bone outside the body.

One of the greatest challenges tissue engineers face in growing bone in the laboratory is recreating the conditions that occur inside the body. The recipe for growing healthy bones includes not only a precise biological mix -- bone cells called "osteoblasts" and several growth factors that osteoblasts use to build the mineralized matrix of bones -- but also mechanical stimulation. Astronauts whose bones become brittle after months in orbit are a testament to the importance that mechanical stress plays in bone growth. In orbit, their skeletons aren't subject to the everyday stresses of gravity.

Tissue engineers at Rice placed bone marrow-derived osteoblasts from rats into centimeter-wide plexiglass chambers containing a thin stack of titanium fiber mesh. The samples were covered with a liquid growth medium -- a bath of chemicals that promotes bone growth -- and sealed in an incubator. After letting the cultures sit overnight -- to give the cells time to attach themselves to the mesh -- engineers pumped growth medium through the cultures for 16 days. Bone cultures were subjected to a range of three different flow rates to provide mechanical stimulation, and another set of cultures were grown in a motionless bath.

Results of the research appear in the current issue of the Proceedings of the National Academy of Sciences USA.

"Researchers have used fluid flow to stimulate bone growth before, but no one has looked at its effect on three-dimensional cultures that have been subjected to continuous stimulation for several days," said Tony Mikos, the John W. Cox Professor of Bioengineering. "We found that even the lowest flow rate produced a significant increase in the formation of mineralized bone. Moreover, the miner
'"/>

Contact: Jade Boyd
jadeboyd@rice.edu
713-348-6778
Rice University
3-Oct-2002


Page: 1 2

Related biology news :

1. UCSD bioengineers develop first genome-scale computational model of gene regulation
2. Dartmouth bioengineers develop humanized yeast
3. Tufts University bioengineers discover secret of spider, silkworm fiber strength
4. UCSD bioengineers use computer model to predict evolution of bacteria
5. UCSD bioengineers develop first computer model that predicts disease variant based on genetic defect
6. Possible cause and treatment for shock uncovered by UC San Diego bioengineers
7. NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
8. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
9. Wisconsin scientists develop quick botox test
10. Bronfenbrenner book sums up human development
11. Researchers develop fast track way to discover how cells are regulated

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... NEW YORK , May 16, 2016   ... authentication solutions, today announced the opening of an IoT ... to strengthen and expand the development of embedded ... provides an unprecedented level of convenience and security with ... to authenticate one,s identity aside from DNA. EyeLock,s platform ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Sequenom, Inc. (NASDAQ: SQNM ... lives through the development of innovative products and services, ... the United States denied its petition to ... of Sequenom,s U.S. Patent No. 6,258,540 (",540 Patent") are ... by the Supreme Court,s Mayo Collaborative Services v. Prometheus ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and ... clinical trial team. , Using the CONSULT module, patients and physicians can schedule a ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... operations for Amgen, will join the faculty of the University of North ... adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on ...
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
Breaking Biology Technology:
Cached News: