HOME >> BIOLOGY >> NEWS
Rice centromere, supposedly quiet genetic domain, surprises

MADISON - Probing the last genomic frontier of higher organisms, an international team of scientists has succeeded in sequencing a little understood - but critical - genetic domain in rice.

In doing so, the group, led by Jiming Jiang, a professor of horticulture at the University of Wisconsin-Madison, and C. Robin Buell of the Institute for Genomic Research in Rockville, Md., has exposed a supposedly barren region of a rice chromosome known as the centromere. The work, published in the current (Jan. 11) online editions of the journal Nature Genetics, reveals for the first time that a native centromere, typically composed of enormous spans of indecipherable, non-coding DNA, contains active genes.

The feat promises to help fill in a key genetic void and enhance the scientific understanding of chromosomes, the molecular structures that are found in all animal and plant cells, and are the essential carriers of hereditary information, enabling the processes of cell division and replication.

At a practical level, the work is a necessary step toward science's long-term goal of creating an artificial chromosome for plants, says Jiang. Such a tool, now available only for humans and yeast, would be an invaluable aid to scientific study and a precursor to precision plant engineering techniques.

"This is a significant step," says Jiang. "This is the first centromere to be sequenced at this level for any higher organism."

The centromere of rice, says Jiang, lent itself to sequencing because, unlike centromeres from other organisms, it is of a manageable size. Most centromeres are composed of vast stretches of what was once called "junk DNA," seemingly nonsense genetic sequences with no apparent coding function.

"They're humongous," Jiang explains. The DNA within centromeres is "highly repetitive, and it is resistant to mapping, cloning and sequencing," he says.

The finding of active genes was a surprise, says Jiang. The n
'"/>

Contact: Jiming Jiang
jjiang1@wisc.edu
608-262-1878
University of Wisconsin-Madison
11-Jan-2004


Page: 1 2 3

Related biology news :

1. Ears cant hear when special sensory cells dont stay quiet
2. Study backs theory that accumulating mutations of quiet genes foster aging
3. Researchers determine genetic cause of Timothy syndrome
4. Rare childhood genetic syndrome identified
5. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
6. Scientists decipher genetic code of biothreat pathogen
7. Chemical genetics identifies SARS inhibitors
8. 22nd amino acid synthesized and added to genetic code of e. coli bacteria
9. The impact of genetic variations on the treatment of early rheumatoid arthritis
10. Adaptive changes in the genome may provide insight into the genetics of complex disease
11. New genetic hypothesis for the cause of autism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/31/2020)... ... 2020 , ... Justin Zamirowski to lead upcoming launches of ... on Type 2 diabetes and associated comorbidities. , Justin brings over 20 years ... As Chief Commercial Officer, Justin will lead Better Therapeutics’ efforts in ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/2/2020)... FREDERICK, Md. (PRWEB) , ... ... ... company, Molecular Biology Systems, B.V. (MBS) has announced a publication detailing the ... a one-step reverse transcription polymerase chain reaction (RT-PCR) in 16 minutes. The ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... ... August 11, 2020 , ... The FSHD Society ... Muscular Dystrophy Clinical Trial Research Network (FSHD CTRN), with consideration of ... a consortium of academic research centers in the United States and Europe with ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... Introducing Ardent ... for transformative growth, , Known as MediVet Biologics since its ... , The new Ardent Animal Health will build on its base of ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... leading global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, ... have entered into a strategic partnership whereby Catalent will provide support for the ...
(Date:7/18/2020)... ... 16, 2020 , ... After research model surgery and catheter implantation, the long ... only the beginning of a successful study, while protecting and accessing the catheter or ... Head of Surgery from Envigo in a live webinar on ...
Breaking Biology Technology:
Cached News: