Rimonbant shows promise in addressing multiple risk factors

Quebec City, Canada, March 9, 2004 - Results of a Phase III clinical trial (RIO-Lipids or Rimonabant In Obesity) comparing rimonabant, the first drug in a new class called Selective CB1 Blockers (or SCB1Bs), to placebo found that overweight or obese patients with untreated dyslipidemia (high triglycerides, low HDL-cholesterol) lost almost 20 lbs (8.6 kg) when treated for a year with rimonabant 20mg. Weight loss was accompanied by a decrease in waist size of 3.4 inches (9.1 cm) demonstrating a significant reduction in abdominal obesity, an independent marker for heart disease. Dramatic improvements were also seen in lipid profile with a 23% increase in HDL-cholesterol (good cholesterol) and a 15% decrease in triglycerides. Improvements in glucose tolerance and insulin levels were also observed. In another important finding, the number of patients diagnosed at baseline with metabolic syndrome,1 who were treated with rimonabant 20mg, was reduced by half. The drug was also found to be safe and well-tolerated.

Rimonabant works by inhibiting the CB1 receptor, one of two receptors found in a newly described physiological system called the Endocannabinoid System (EC System), believed to play a critical role in the regulation of food intake and energy expenditure.

"While the weight loss was clinically relevant, what is truly remarkable in the RIO-Lipids study is the significant effect rimonabant had on improving associated cardiovascular risk factors," said Jean-Pierre Despr's, principal investigator for RIO-Lipids and Professor in the Department of Food Sciences and Nutrition and Medicine at Laval University, and Director of Research at the Quebec Heart Institute located at the Laval Hospital Center in Quebec City, Canada. "Rimonabant appears to have a direct effect on fat cells which may be contributing to the beneficial effects of this drug on abdominal obesity and associated risk factors. Couple this with the markedly

Contact: Glenn Lehrman

Page: 1 2 3 4 5 6

Related biology news :

1. New study shows hope for treating inhalant abuse
2. Chemical derived from vitamin-E shows early promise as cancer drug
3. Cancer vaccine based on pathogenic listeria bacteria shows promise targeting metastases
4. Trial shows which brain cancer patients benefit from temozolomide
5. New research shows plants can shuffle and paste gene pieces to generate genetic diversity
6. Preclinical safety study shows adipose-derived stem cells improve heart function after heart attack
7. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
8. A probable cause for high blood pressure identified - shows links with diabetes
9. Blue marlin in gulf have high mercury levels, A&M study shows
10. New research shows air pollution can reduce childrens lung function
11. Pneumococcal vaccine reduces ear infections, pneumonia, new study shows

Post Your Comments:

(Date:10/12/2015)... 2015 Hoyos Labs ... company, will introduce its new biometric four-finger ... simultaneously, providing an unprecedented level of security ... the new biometric standard for secure transactions ... from financial services to healthcare are implementing ...
(Date:10/9/2015)... , Oct. 09 2015 ... addition of the "Samsung Galaxy S6 ... report to their offering. --> ... the "Samsung Galaxy S6 Fingerprint Sensor ... their offering. --> Research and ...
(Date:10/8/2015)... October 8, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... Wocket® smart wallet announces that revenues for the ... $410,000 compared with $113,00 for the three months ... months ended September 30, 2015 were approximately $520,000. ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... CAMBRIDGE, Mass. , Oct. 13, 2015 ... quantitative methodologies at critical decision points throughout the drug ... at QSP Congress Boston 2015 on October 20-22, 2015 ... John Burke , PhD, Co-Founder, President, and CEO of ... drug discovery from early research to clinical trials" on ...
(Date:10/13/2015)... ... October 13, 2015 , ... ... antibodies, today announced that it has received a Phase I Small Business Innovative ... the National Institute of General Medical Sciences (NIGMS), will fund the development of ...
(Date:10/13/2015)... Florida , October 13, 2015 ... specializing in the development of innovative peptide and gene-based ... metastatic disease, will be a featured presenting company at ... at the Wyndham Grand Hotel in Jupiter, ... TapImmune, Inc. (TPIV), a clinical-stage immunotherapy company ...
(Date:10/13/2015)... Hills, MI (PRWEB) , ... October 13, 2015 ... ... Michigan-based manufacturer and distributor of automation systems, material handling solutions and components, is ... Located off I-94 near State Street, the facility is Exotic’s second major expansion ...
Breaking Biology Technology:
Cached News: