Rising expectations from new yeast study

Although studying the mating response of brewer's yeast may not stimulate most people, it's exciting stuff to University of Illinois at Chicago biologists David Stone and Metodi Metodiev. In the May 24 issue of the journal Science, they report an important finding about the way cells communicate in the yeast Saccharomyces cerevisiae. The finding may have implications for developing a range of pharmaceuticals, including new cancer treatments.

Saccharomyces cerevisiae has been widely studied and was the first eukaryote to have its genome fully sequenced. What makes this microbe a great research tool is that, although it is simpler than higher eukaryotes, its basic mechanisms of cellular function are the same as those of plant and animal cells, despite a billion years of divergent evolution.

Stone, an associate professor of biological sciences, and Metodiev, a research assistant professor, specialize in signal transduction the processes whereby cells consider the many thousands of stimuli they encounter and turn this information into the responses necessary for life. Stone began his study of yeast signal transduction in 1988.

The yeast exists as two mating types, like opposite sexes. Each mating type proliferates rapidly when grown in separate cultures, but when mixed, the opposite types communicate by secreting a chemical love potion called a pheromone. Exposure to pheromone causes the cells to stop dividing, then fuse, or mate.

"To us, the two most important aspects of the mating response are that first, pheromone triggers cells to stop dividing. Second, the cells are able to orient their growth toward the source of pheromone, a process called chemotropism," said Stone. "Growth control is of obvious importance because of its relationship to cancer. Chemotropism is of fundamental importance because we find many chemotropic phenomena in development in adult organisms. For example, our immune systems respond to chemical signals. When

Contact: Paul Francuch
University of Illinois at Chicago

Page: 1 2 3

Related biology news :

1. Rising childhood leukaemia incidence prompts conference
2. Rising ozone levels pose challenge to U.S. soybean production, scientists say
3. Rising Maryland to welcome new biotech president
4. Rising rates of overweight among preschoolers in developing countries
5. Binocular rivalry: Fulfilling visual expectations
6. Purdue yeast makes ethanol from agricultural waste more effectively
7. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
8. Protein-only prions confirmed in FSU yeast study
9. Bakers yeast rises from genome duplication
10. Building a better atlas of yeast proteins
11. New findings in yeast may reveal why growing older is the greatest carcinogen in humans

Post Your Comments:

(Date:11/3/2018)... ... November 01, 2018 , ... The Conference ... be held February 6-8, 2019 at the Crowne Plaza Times Square in New ... plenary session is Genentech’s Global Franchise Leader in Cancer Immunotherapy Biomarkers and IO360° ...
(Date:11/3/2018)... Colo. (PRWEB) , ... November 01, 2018 , ... As ... Union (EU) continue to alter the landscape of quality systems for manufacturers worldwide. To ... medical device makers must act on now. , “While 2020 may sound far off, ...
(Date:10/31/2018)... Fla. (PRWEB) , ... October 31, 2018 , ... ... mark of its FebriDx® test, clearing the way for its immediate launch in ... rapid, accurate, and simple to use point-of-care test that is expected to contribute ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... YORK (PRWEB) , ... November 05, 2018 , ... ... is launching live educational support for healthcare professionals through its website, http://www.glycomark.com ... will offer a live chat and video option via the website in November ...
(Date:11/3/2018)... ... November 01, 2018 , ... ... Consortium Summit. Dr. Jean Mulinde, Senior Advisor, Division of Clinical Compliance Evaluation, CDER, ... safety and ensure data reliability. , What should clinical research industry stakeholders keep ...
(Date:10/31/2018)... , ... October 30, 2018 , ... Rooam , ... launch operations in Chicago this winter. After its acquisition of the Tally payment app, ... transactions and set default tips, Rooam will grow its market share and increase the ...
(Date:10/31/2018)... Calif. (PRWEB) , ... October 30, 2018 , ... Pippa Rose is a young Labrador ... around one year old, Pippa suffered a partial tear to the cruciate ligament in her ... to run or go on walks. Kinsley reported that it broke her heart to ...
Breaking Biology Technology:
Cached News: