Rising expectations from new yeast study

ever we get a wound, immune cells detect the source of chemical signals coming from the wound and migrate toward it. Chemotropism is also relevant to cancer because tumor cells metastasize in response to chemical signals released by specific tissues."

At the molecular level, the yeast mating response works through a series of steps: the signaling pheromone binds to a receptor on the cell membrane, thus activating a signaling molecule called a G-protein. G-protein is made of two parts, G-alpha and G-beta-gamma. G-beta-gamma triggers a sequence of signals along a pathway of enzymes, ending in the activation of a protein called a MAPK, which enters the cell nucleus and affects targets that block cell division.

To resume division, the cells must turn off the mating signal. Exactly how this worked was unclear until Metodiev and Stone, using a research technique called proteomics, discovered that the other part of the G-protein (G-alpha) eventually bypasses this linear signal progression and binds directly to the bottom-level MAPK. It then diverts the MAPK from the nucleus, which allows the growth signal to turn back on. This G-alpha/MAPK binding was previously unknown.

The UIC scientists also discovered that G-alpha lures the MAPK enzymes to the cell's plasma membrane where it works to help orient cell growth toward another cell's chemical signal.

"In contrast to traditional therapies, today's modern drug discovery process is directed at specific proteins and protein-protein interactions," said Metodiev. "In this case, we have demonstrated the interaction of two very important and well-characterized signaling molecules, G-alpha and MAPK. This interaction is a natural target of drug discovery research."

"It's basic scientific research but definitely has the potential to influence therapeutics," said Stone. "There are many human diseases related to problems in controlling cell growth and differentiation. For example, if we know

Contact: Paul Francuch
University of Illinois at Chicago

Page: 1 2 3

Related biology news :

1. Rising childhood leukaemia incidence prompts conference
2. Rising ozone levels pose challenge to U.S. soybean production, scientists say
3. Rising Maryland to welcome new biotech president
4. Rising rates of overweight among preschoolers in developing countries
5. Binocular rivalry: Fulfilling visual expectations
6. Purdue yeast makes ethanol from agricultural waste more effectively
7. Carnegie Mellon U biologists identify critical player in yeast ribosome assembly
8. Protein-only prions confirmed in FSU yeast study
9. Bakers yeast rises from genome duplication
10. Building a better atlas of yeast proteins
11. New findings in yeast may reveal why growing older is the greatest carcinogen in humans

Post Your Comments:

(Date:4/16/2019)... ... April 16, 2019 , ... The ... signature events: The 2019 ISPE Biopharmaceutical Manufacturing Conference , on 18–20 June ... place in one of the most influential bio hubs, Boston, Massachusetts USA, these ...
(Date:4/9/2019)... ... ... The McLeod Center for Cancer Treatment and Research has been ... conducted by an independent, third-party panel of experts in radiation oncology, patient safety and ... McLeod is the only such cancer center in South Carolina. The hospital also represents ...
(Date:4/4/2019)... ... April 02, 2019 , ... ... company, will present results demonstrating that RNA genetic testing (RGT), as a supplement ... study, awarded as a Top Rated poster, is one of 13 presentations at ...
Breaking Biology News(10 mins):
(Date:3/29/2019)... ... March 28, 2019 , ... Specific ... CARB-X has proceeded with a second stage of funding for Specific’s Reveal™ rapid ... is on top of the $1.7 million already awarded by CARB-X. The additional ...
(Date:3/23/2019)... Pa. (PRWEB) , ... March 22, 2019 , ... ... of its LenS3 Multi-Angle Light Scattering (MALS) detector , offering a revolutionary ... of synthetic polymers, polysaccharides, proteins, and biopolymers. A novel optical design, a unique ...
(Date:3/19/2019)... ... ... free webinar will review strategies for data management in modular and adaptive clinical ... times by up to 30 percent, reducing cost while increasing quality, achieving clinical site set-up ... to migrate data – reducing risk and impact on trial success, trial teams, and trial ...
(Date:3/14/2019)... ... March 14, 2019 , ... EyeCRO LLC has been ... EyeCRO joins the Department of Veterans Affairs, the Oklahoma Medical Research Foundation, Oklahoma ... institution in Oklahoma to receive this prestigious endorsement. The award letter from ...
Breaking Biology Technology:
Cached News: