HOME >> BIOLOGY >> NEWS
Rockefeller and Aaron Diamond researchers say resistance to HIV drugs may be higher than previously thought

For example, the death rate from AIDS dropped 47 percent in the United States between 1996 and 1997. Scientists have been concerned, however, that the success of antiretroviral drugs has resulted in the increased transmission of drug-resistant strains of the virus.

To measure the prevalence of this resistance, the researchers performed genetic analysis on virus in blood drawn from 80 patients to find any HIV mutations associated with drug resistance. They found that 13 of the patients, or 16.3 percent of the total, carried strains that were less susceptible to an antiretroviral drug by a factor of three or more. The scientists said the actual percentage of patients carrying resistant strains in the group is probably higher because other mutations that confer resistance have not yet been identified. Viruses resistant to more than one drug were found in only 3 patients, constituting 3.8 percent of the total.

"Rather than jumping to any conclusions about whether resistant strains of HIV are being widely spread, we need to measure the resistance in other populations," says study co-author Martin Markowitz, M.D. "If it appears that HIV resistance to drugs is becoming more common in the future, we may have to alter current strategies for treatment. But until we know more, we do not want patients to stop taking drugs because in most cases they are quite effective." The scientists recommend initiation of clinical trials to determine whether therapy guided by resistance testing would work better than issuing the standard drug or combination of drugs. Such testing might lead to drug therapies tailored around the specific resistant HIV strain found in a particular patient.

Boden's and Markowitz's co-authors are Arlene Hurley, R.N., Linqi Zhang, Ph.D., Yunzhen Cao, M.D., Yong Guo, M.S. Elizabeth Jones, B.A., John Tsay, B.A., James Ip, B.A., of the Aaron Diamond Aids Research Center at Rockefeller University, Charles Farthing, M.D., of
'"/>

Contact: Jim Stallard
stallaj@rockvax.rockefeller.edu
212-327-8977
Rockefeller University
21-Sep-1999


Page: 1 2 3

Related biology news :

1. Rockefeller University scientists take on controversial vibration theory of smell
2. By the year 2050, human population could add 2.6 billion people, reports Rockefeller scientist
3. White House awards National Medal of Science to Rockefeller Universitys James Darnell
4. Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
5. Rockefeller scientists identify natural proteins that push stem cells to produce hair, not skin
6. Rockefeller, Weill Cornell researchers find link between estrogen, brain structure changes
7. Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors
8. Another transmembrane protein structure solved by Rockefeller scientists
9. Rockefeller researchers identify defense system in plants
10. Rockefeller University Centennial Symposium to explore biology of drug abuse and addiction
11. Rockefeller University researchers discover immune-cell mechanism that boosts therapeutic antibody potency

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: