HOME >> BIOLOGY >> NEWS
Rockefeller researchers inject cells, boost immune system in humans

Findings take important first step toward vaccines for cancer, viruses

A single injection of specialized immune system cells -- removed from the bloodstream and exposed to a foreign substance -- can trigger a potent immune response in humans that lasts for months, Rockefeller University researchers report. The experiment provides the first conclusive evidence that one dose of these cells, called dendritic cells, can prompt a strong immune response, and it suggests new ways of improving vaccines and protecting against cancer.

"We've shown for the first time that a single injection of mature dendritic cells can induce a significant level of immunity in people," says Rockefeller's Nina Bhardwaj, M.D., Ph.D., associate professor for clinical investigation and senior author of the study. "The results indicate that this method could be a powerful new way to fight cancers and chronic infections like HIV." Bhardwaj, along with lead author Madhav Dhodapkar, M.D., a Rockefeller clinical scholar and assistant professor, and nine other colleagues reported the results of the experiment in the July 15 issue of the Journal of Clinical Investigation.

Ralph Steinman, M.D., another co-author and head of Rockefeller's Laboratory of Immunology and Cellular Physiology, which gave birth to much research on dendritic cells, says the new technique will probably first be used to treat people with advanced cancers and those who have gotten rid of the disease but are vulnerable to a recurrence. The other main targets will be chronic viral infections such as HIV, hepatitis, Epstein-Barr virus and herpes.

Dendritic cells have become the subject of increased interest by immunologists. Located in most tissues, dendritic cells are responsible for signaling the presence of an intruder to the body's T cells, which play the primary role in the immune response against invading microbes. Dendritic cells capture antigens from the foreign substance and present them to t
'"/>

Contact: Joseph Bonner
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
15-Jul-1999


Page: 1 2 3 4

Related biology news :

1. Rockefeller University scientists take on controversial vibration theory of smell
2. By the year 2050, human population could add 2.6 billion people, reports Rockefeller scientist
3. White House awards National Medal of Science to Rockefeller Universitys James Darnell
4. Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
5. Rockefeller scientists identify natural proteins that push stem cells to produce hair, not skin
6. Rockefeller, Weill Cornell researchers find link between estrogen, brain structure changes
7. Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors
8. Another transmembrane protein structure solved by Rockefeller scientists
9. Rockefeller researchers identify defense system in plants
10. Rockefeller University Centennial Symposium to explore biology of drug abuse and addiction
11. Rockefeller University researchers discover immune-cell mechanism that boosts therapeutic antibody potency

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/13/2017)... UBM,s Advanced Design and Manufacturing event in ... and evolving technology through its 3D Printing and Smart ... the expo portion of the event and feature a ... on trending topics within 3D printing and smart manufacturing. ... will take place June 13-15, 2017 at the Jacob K. ...
(Date:4/11/2017)... -- Research and Markets has announced the addition of ... offering. ... market to grow at a CAGR of 30.37% during the period ... has been prepared based on an in-depth market analysis with inputs ... growth prospects over the coming years. The report also includes a ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... The ... three Winners and six Finalists of the 2017 Blavatnik Regional Awards for Young ... Family Foundation and administered by the New York Academy of Sciences to honor ...
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... today it will be hosting a Webinar titled, “Pathology is going digital. Is ... , on digital pathology adoption best practices and how Proscia improves lab economics ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
Breaking Biology Technology:
Cached News: