HOME >> BIOLOGY >> NEWS
Rockefeller researchers inject cells, boost immune system in humans

Findings take important first step toward vaccines for cancer, viruses

A single injection of specialized immune system cells -- removed from the bloodstream and exposed to a foreign substance -- can trigger a potent immune response in humans that lasts for months, Rockefeller University researchers report. The experiment provides the first conclusive evidence that one dose of these cells, called dendritic cells, can prompt a strong immune response, and it suggests new ways of improving vaccines and protecting against cancer.

"We've shown for the first time that a single injection of mature dendritic cells can induce a significant level of immunity in people," says Rockefeller's Nina Bhardwaj, M.D., Ph.D., associate professor for clinical investigation and senior author of the study. "The results indicate that this method could be a powerful new way to fight cancers and chronic infections like HIV." Bhardwaj, along with lead author Madhav Dhodapkar, M.D., a Rockefeller clinical scholar and assistant professor, and nine other colleagues reported the results of the experiment in the July 15 issue of the Journal of Clinical Investigation.

Ralph Steinman, M.D., another co-author and head of Rockefeller's Laboratory of Immunology and Cellular Physiology, which gave birth to much research on dendritic cells, says the new technique will probably first be used to treat people with advanced cancers and those who have gotten rid of the disease but are vulnerable to a recurrence. The other main targets will be chronic viral infections such as HIV, hepatitis, Epstein-Barr virus and herpes.

Dendritic cells have become the subject of increased interest by immunologists. Located in most tissues, dendritic cells are responsible for signaling the presence of an intruder to the body's T cells, which play the primary role in the immune response against invading microbes. Dendritic cells capture antigens from the foreign substance and present them to t
'"/>

Contact: Joseph Bonner
runews@rockvax.rockefeller.edu
212-327-7900
Rockefeller University
15-Jul-1999


Page: 1 2 3 4

Related biology news :

1. Rockefeller University scientists take on controversial vibration theory of smell
2. By the year 2050, human population could add 2.6 billion people, reports Rockefeller scientist
3. White House awards National Medal of Science to Rockefeller Universitys James Darnell
4. Lasker Award honors Rockefeller University biochemist for pioneering studies of gene activation
5. Rockefeller scientists identify natural proteins that push stem cells to produce hair, not skin
6. Rockefeller, Weill Cornell researchers find link between estrogen, brain structure changes
7. Rockefeller researchers provide the first functional evidence for mammalian pheromone receptors
8. Another transmembrane protein structure solved by Rockefeller scientists
9. Rockefeller researchers identify defense system in plants
10. Rockefeller University Centennial Symposium to explore biology of drug abuse and addiction
11. Rockefeller University researchers discover immune-cell mechanism that boosts therapeutic antibody potency

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... ... 13, 2020 , ... Acumed LLC today announced that it ... of the Louisville-based company’s orthobiologics portfolio. Under the terms of the agreement, Acumed ... phosphate-based bone allograft (Trabexus) and calcium phosphate-based biocement (Fortera). Vivorte will continue to ...
(Date:3/10/2020)... ... March 10, 2020 , ... ... of Directors. Dr. Narasimhan is Senior Vice President of Strategic Initiatives, Portfolio Innovation ... Board of Directors of Cytonus, we are extremely pleased to welcome Manisha Narasimhan ...
(Date:3/5/2020)... ... March 05, 2020 , ... ... its Scientific Advisory Board (SAB) comprised of the industry’s key opinion leaders ... therapy centers, and private industry. Cytonus is a leading cell-based platform technology ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... March 03, 2020 , ... ... pharmaceutical, biotech and medical device industries, was recognized by INC. 5,000 on an ... annual lists to note industry leaders greatly impacting their spheres of influence and ...
(Date:2/21/2020)... ... ... In a free session on Tuesday, March 10, 2020 at ... BS, MS, Vice President Rare, Orphan and Pediatric Diseases, and Rachael Young, Associate Director, ... patients, sites and sponsors. , When planning a rare disease clinical trial, drug developers ...
(Date:2/19/2020)... ... February 18, 2020 , ... ... populations down to the strain level, recently unveiled a novel DNA isolation product. ... and unbiased isolation of high molecular weight (HMW) single-stranded DNA (ssDNA) in excess ...
(Date:2/11/2020)... ... February 11, 2020 , ... Synagro Technologies, Inc. , ... announced that the City of Fort Worth has partnered with Synagro of Texas-CDR ... April of 2020, Synagro will assume operation of the city’s current biosolids management ...
Breaking Biology Technology:
Cached News: