HOME >> BIOLOGY >> NEWS
Role of key protein that may stave off inherited form of Alzheimer's disease discovered by UC Irvine researchers

Research on early-onset form of neural disease may lead to prevention methods

A key protein involved in the regulation of calcium in brain cells may influence the development of therapies and preventive methods for early-onset familial Alzheimer's disease, an inherited form of this neurological disorder that affects adults in their 30s and early 40s, UC Irvine neuroscience researchers have found.

Malcolm A. Leissring and Frank M. LaFerla, in collaboration with Ian Parker, all of UCI's Department of Neurobiology and Behavior, have discovered that a protein named calsenilin can offset calcium imbalances in brain cells that can lead to the neural changes associated with Alzheimer's disease. Among its roles, calcium helps regulate numerous cellular activities, but these imbalances, however, are not related to dietary intake of calcium, the UCI researchers point out. Their findings appear in the July 18, 2000 issue of Proceedings of the National Academy of Sciences.

Most early-onset familial Alzheimer's disease cases are triggered by mutations in the genes that produce the protein presenilin. Mutations in these genes disrupt the proper handling of calcium inside brain cells, which can contribute to the identifying factors of Alzheimer's disease. These pathological features include the development of brain plaques caused by increased production of ß-amyloid proteins, neural fibril formation and cell death.

The UCI researchers have found in tests using frog eggs that the calsenilin protein, when bound to specific sites on the presenilin protein, can counteract the effects of mutant presenilin by stabilizing the activity of the mechanisms, which are called signaling pathways, that distribute calcium within cells. Calsenilin does this by reversing the increase of calcium signaling caused by presenilin mutations. Researchers from Harvard Medical School and Mount Sinai School of Medicine in New York, who worked with UCI res
'"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
31-Jul-2000


Page: 1 2 3

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. Researchers identify protein promoting vascular tumor growth
3. UCI scientists successfully target key HIV protein; breakthrough may lead to new drug therapies
4. Experimental drug shown to block mutant protein causing blood disease
5. Loss of the neuronal adhesion protein d-catenin leads to severe cognitive dysfunction
6. Images of tail of protein needed for cell multiplication suggest anticancer drug targets
7. New dye directly reveals activated proteins in living cells
8. Disruption of protein-folding causes neurodegeneration, mental retardation
9. A new protein is discovered to play a key role in cancer progression
10. Optimizing proteins death domain halts leukemia in laboratory study
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: