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Rutgers-Newark biologist links presence of protein to spread of cancerous cells

Biology researchers at Rutgers-Newark have identified a new link between a specific protein and its role in determining how cancerous cells divide, spread and form new tumors in other parts of the human body.

In the article, "Rho Overexpression Leads to Mitosis-associated Detachment of Cells from Epithelial Sheets: A Link to the Mechanism of Cancer Dissemination," appearing in the August 9-13 edition of the Proceedings of the National Academy of Science, Rutgers-Newark Biology Chair Edward Bonder reveals that the overexpression of Rho protein in certain cells can cause the cells to take on a rounded shape, bud, break off and form cell colonies distant to the original cell colony.

By connecting the presence of Rho proteins to this cell division and movement phenomenon, researchers may have begun to pave the way for the development of more specific approaches to treat cancerous cells. For example, chemotherapy agents act to eradicate any cell that is dividing. With this approach, healthy cells are destroyed along with unhealthy ones, leading to the debilitating side effects experienced by many chemotherapy patients. Through the identification of the novel effect of a Rho pathway within a dividing cell, researchers may be able to develop more targeted pharmacological approaches that can attack unhealthy dividing cells while leaving the healthy ones intact.

Rho proteins serve as a regulator with the ability to turn on or activate other proteins, including myosin II, a motor protein instrumental in taking energy and converting it to movement in the human body. The researchers' findings identified a link between cell division and a cell's ability to remain associated with its parent tissue.

According to Dr. Bonder, researchers uncovered this information while attempting to learn more about what regulates the changes of cells within healing wounds in epithelial (skin) cells. After introducing Rho into a culture of cells, some cells budded
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Contact: Peter Haigney
phaigney@andromeda.rutgers.edu
973-353-1663
Rutgers, the State University of New Jersey
11-Aug-2004


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