HOME >> BIOLOGY >> NEWS
Rutgers-Newark biologist links presence of protein to spread of cancerous cells

Biology researchers at Rutgers-Newark have identified a new link between a specific protein and its role in determining how cancerous cells divide, spread and form new tumors in other parts of the human body.

In the article, "Rho Overexpression Leads to Mitosis-associated Detachment of Cells from Epithelial Sheets: A Link to the Mechanism of Cancer Dissemination," appearing in the August 9-13 edition of the Proceedings of the National Academy of Science, Rutgers-Newark Biology Chair Edward Bonder reveals that the overexpression of Rho protein in certain cells can cause the cells to take on a rounded shape, bud, break off and form cell colonies distant to the original cell colony.

By connecting the presence of Rho proteins to this cell division and movement phenomenon, researchers may have begun to pave the way for the development of more specific approaches to treat cancerous cells. For example, chemotherapy agents act to eradicate any cell that is dividing. With this approach, healthy cells are destroyed along with unhealthy ones, leading to the debilitating side effects experienced by many chemotherapy patients. Through the identification of the novel effect of a Rho pathway within a dividing cell, researchers may be able to develop more targeted pharmacological approaches that can attack unhealthy dividing cells while leaving the healthy ones intact.

Rho proteins serve as a regulator with the ability to turn on or activate other proteins, including myosin II, a motor protein instrumental in taking energy and converting it to movement in the human body. The researchers' findings identified a link between cell division and a cell's ability to remain associated with its parent tissue.

According to Dr. Bonder, researchers uncovered this information while attempting to learn more about what regulates the changes of cells within healing wounds in epithelial (skin) cells. After introducing Rho into a culture of cells, some cells budded
'"/>

Contact: Peter Haigney
phaigney@andromeda.rutgers.edu
973-353-1663
Rutgers, the State University of New Jersey
11-Aug-2004


Page: 1 2

Related biology news :

1. Rutgers-Newark scientist: Mosquitoes may carry lethal parasite
2. Grant of powerful computer to Rutgers-Newark will increase understanding of brain activity
3. Tracing genes, biologists show lizard migration is traced to Florida
4. UCLA molecular biologists uproot the tree of life
5. UCSD biologists develop super-endurance strain of mice
6. Springtime blooms seen earlier now than in the past, say Boston University biologists
7. Study by Tufts biologist provides window into progression of some degenerative diseases
8. UCSD biologists discover cells defense mechanism against class of disease-causing bacterial toxins
9. U of T microbiologists achieve results with pattern recognition software
10. Carnegie Mellon computational biologist Russell Schwartz receives prestigious CAREER award
11. Parting genomes: UA biologists discover seeds of speciation

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/27/2020)... , ... January 27, 2020 , ... On Thursday, February ... Solutions Life Sciences, Reed Tech and Richard Castle, Global Account Manager Medical ... discussing the procedure, other topics include EU MDR timing deadlines, best practices in creating ...
(Date:1/24/2020)... FARMINGTON, Conn. (PRWEB) , ... January 24, 2020 , ... ... populations down to the strain level, today announced that the company will debut a ... place January 26-29. , The new product, Shoreline Biome's Rapid Prep kit, is ...
(Date:1/24/2020)... ... January 24, 2020 , ... Worldwide Business with ... President Dr. Stanley Stanbridge and Vice President of Sales and Marketing Jeff Maier to ... Network as sponsored content on Sunday, Jan. 26, 2020 at 5:30 p.m. EST and ...
Breaking Biology News(10 mins):
(Date:2/19/2020)... ... February 18, 2020 , ... ... populations down to the strain level, recently unveiled a novel DNA isolation product. ... and unbiased isolation of high molecular weight (HMW) single-stranded DNA (ssDNA) in excess ...
(Date:2/19/2020)... ... February 19, 2020 , ... Red ... life sciences industry, today announced the opening of a new office in Tokyo, ... Nucleus R&D. , Red Nucleus announced the new office in response to customer ...
(Date:2/11/2020)... ... February 11, 2020 , ... INSPAN ... a long-term follow-up clinical study of outpatient L4-L5 lumbar interspinous fixation for ... extension block design, the Inspan device fixates the spine to allow for ...
(Date:2/10/2020)... ... ... R3 Medical Training announced it is now registering for its next Comprehensive ... is hands on involving real patients and stem cell biologics, with every attendee receiving ... Training Course has received rave reviews from attendees, who love the hands on nature ...
Breaking Biology Technology:
Cached News: