Rutgers chemist uses NMR to elucidate protein-DNA i...( base but each base will only bond wit...)

Rutgers chemist uses NMR to elucidate protein-DNA interaction

base, but each base will only bond with one other specific base. For example, Adenine (A) will only bond with thymine (T), and guanine (G) will only bond with cytosine (C).

"We know that any protein binds first with any irrelevant DNA sequence, but the interaction is weak. It searches for the correct sequence by sliding along the DNA until it can bind with a specific DNA sequence and form a complex," Kalodimos explained. "This helps us begin to complete the story of how proteins and DNA find each other in a very fast and accurate way. It provides us with a classical model for understanding protein-DNA interaction and offers valuable information about how transcription can be modulated at the gene level."

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Contact: Peter Haigney
phaigney@andromeda.rutgers.edu
973-353-1663
Rutgers, the State University of New Jersey
15-Jul-2004

Page: 1 2
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