HOME >> BIOLOGY >> NEWS
SARS information for antiviral drug design released by Protein Data Bank

NEW BRUNSWICK/PISCATAWAY, N.J. -- The Protein Data Bank (PDB), an international resource for biomedical research with facilities at Rutgers, The State University of New Jersey, has released to the public a three-dimensional crystal structure of the SARS virus main protease enzyme. Its availability to medical researchers worldwide is crucial because this enzyme is considered the primary target for new antiviral drugs being developed to combat the virus.

"The PDB was able to process and release this information so quickly because of the leading-edge technology it employs," said Rutgers Board of Governors Professor of Chemistry and Chemical Biology Helen M. Berman, director of the Protein Data Bank. "It is critically important that these kinds of data are made available quickly to expedite the drug discovery process, especially when we are dealing with a potentially epidemic disease like SARS. The rapid processing possible by the PDB is going to become increasingly important as we release structures with such medically important potential."

The actual structure determination was made by Structural GenomiX, Inc., a biotechnology company in San Diego. The company deposited its data with the PDB, which were processed rapidly by a team at Rutgers to make the data available in the public database.

"Having the three-dimensional structure of the SARS virus protease should accelerate the search for effective treatments for SARS," said Eddy Arnold, professor, Rutgers' department of chemistry and chemical biology. "Structure-based drug design has had an important impact on the development of anti-AIDS drugs that are now in use, and the rapid progress with characterizing the SARS coronavirus will enable more efficient paths to developing drugs for treating SARS. The PDB renders an important service to the research community in providing rapid access to this crucial information."

The Protein Data Bank is an Internet-accessible internation
'"/>

Contact: Joseph Blumberg
blumberg@ur.rutgers.edu
732-932-7084 x616
Rutgers, the State University of New Jersey
30-Jul-2003


Page: 1 2

Related biology news :

1. Spanish scientists develop powerful tool for exploration and integration of biological information
2. Many scientists believe the dog genome holds information that will benefit human health
3. Research on inherited eye disorders uncovers new information about blood-vessel formation
4. Statistical technique helps researchers gain more information from a single data run
5. CIESIN receives grant to establish government biological information site
6. Workshop takes systems view of information processing in organisms
7. Landmark study offers new information about breast cancer genes
8. Saliva spits out information on chemical exposure
9. Carnegie Mellon receives $2.5M to develop bio-molecular imaging and information discovery systems
10. Data privacy, emergency response, weather prediction to benefit from information technology advances
11. UC San Diego researchers receive $14 million from NSF for 10 new information technology projects

Post Your Comments:
(Date:10/15/2014)... admitted Johannes Gutenberg University Mainz (JGU) as a ... continues to maintain a significant nationwide standing in ... acceptance of Johannes Gutenberg University Mainz as a ... in the national and international competition for the ... Rhineland-Palatinate can be proud that Mainz University has ...
(Date:10/15/2014)... to bacterial pneumonia in female mice to an enzyme ... are naturally more resistant to respiratory infections than males. ... increased resistance to bacterial pneumonia in female mice is ... They also show that this enzyme is ultimately activated ... , The team, lead by Professor Lester Kobzik at ...
(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
(Date:10/22/2014)... and HONG KONG , Oct. 22, ... therapeutics enterprise, announced today that rare disease expert ... vice president, research. Dr. McKew brings more than two ... positions at the National Institutes of Health, Wyeth Research ... Wyeth). Dr. McKew will lead aTyr,s efforts to expand and ...
(Date:10/20/2014)... Convey Computer , the leader ... Iowa State University won first place in the ... HC-2ex, the team’s solution achieved the highest overall performance ... second place finisher. , Experts from all segments of ... long challenge, using a variety of design tools, hardware ...
(Date:10/20/2014)... , October 20, 2014 ... gastrointestinal (GI) disorders and the delivery of care has ... diseases and worrying inequalities in the provision of healthcare ... which was commissioned by United European Gastroenterology (UEG), have ... political and public awareness of the burden of GI ...
(Date:10/20/2014)... 20, 2014 OncLive® ... Cancer Center at Thomas Jefferson University has joined ... the Strategic Alliance Partnership program, the Sidney Kimmel ... to raise awareness of the Center’s cutting-edge research ... projects. Clinicians and other health care professionals from ...
Breaking Biology Technology:aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
Cached News: