HOME >> BIOLOGY >> NEWS
SARS virus can change quickly and unpredictably, analysis indicates

ANN ARBOR, Mich.---The SARS virus is capable of changing rapidly and unpredictably, which could present serious challenges for managing the disease and developing drugs and vaccines to combat it, research at the University of Michigan suggests.

Ever since the SARS virus suddenly appeared in humans, scientists have been speculating about its origins and relationships to other, similar viruses. Using evolutionary analysis of protein sequences, the U-M researchers concluded that the SARS virus represents a different and previously little known lineage that has undergone some recombination, a process that can shuffle genes or gene regions among different viral lineages. This shuffling process provides genetic variation, which can help viruses survive and adapt in new hosts. The results appear in the September issue of the journal Infection, Genetics and Evolution.

The virus associated with SARS (known as SARS-CoV) is a type of coronavirus, so named because of the crown of spikes on its surface. Coronaviruses are divided into three categories: group one has been found in primates, carnivores and the group of animals that includes cattle, pigs and deer; group two occurs in that same group of animals as well as in rodents, birds and animals in the group that includes horses, tapirs and rhinos; group three has been found only in birds. Previous evolutionary analyses have suggested that the SARS virus is equally, but distantly, related to the three coronavirus groups.

Graduate student Joshua Rest and associate professor David Mindell, both of the U-M Department of Ecology and Evolutionary Biology, used a technique that detects recombination by analyzing the gene for a protein known as RNA dependent RNA polymerase (RDRP). In their analysis, one end of the RDRP gene appeared most closely related to group 3 coronaviruses, but the other end appeared distantly related to all three groups, suggesting that the RDRP gene in SARS-CoV had been cobbled together
'"/>

Contact: Nancy Ross Flanigan
rossflan@umich.edu
734-647-1853
University of Michigan
2-Oct-2003


Page: 1 2

Related biology news :

1. Pacific Northwest team unveils largest virus proteome to date
2. No role for simian virus 40 in human pleural mesotheliomas
3. Cannabis may help combat cancer-causing herpes viruses
4. Scientists find nanowires capable of detecting individual viruses
5. $7.5 Million grant to Yale researchers for role of viruses in cancer
6. Simian virus 40 not associated with non-Hodgkin lymphoma, study shows
7. Common cold virus can cause polio in mice when injected into muscles
8. Defensive action by influenza viruses demonstrated by Hebrew university researcher
9. Study of flu patients reveals virus outsmarting key drug
10. Images reveal how rotavirus - leading cause of diarrhea - enters cells
11. Bright idea could doom cancer and viruses, say Purdue scientists

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... (PRWEB) , ... July 03, 2020 , ... ... proud to earn outstanding recognition and multiple awards for not only the products ... ABM portfolio, SoME® Skincare and Vivace® Microneedle RF. All the brands built by ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... announced that it has entered into a multi-year contract with Merus N.V., ... their translational and clinical research strategy to discover and develop ground-breaking drugs. ...
(Date:6/23/2020)... TORONTO (PRWEB) , ... June 22, 2020 , ... The ... time. Typically, ligand binding assays (LBA) have dominated this area. However, the use of ... several years. , This now necessitates the question “How do you choose which approach ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/1/2020)... N.C. (PRWEB) , ... June 29, 2020 , ... ... reported year to date growth of 40% in 2020, despite many obstacles created ... technology, MedShift aims to increase revenue for its partnered medical practices and medical ...
(Date:6/28/2020)... ... June 25, 2020 , ... The Indoor Lab, a ... Safe Space™ for businesses of all types to ensure cleanliness, distancing and occupancy with ... , A Safe Space™ enabled business will provide a health performance index system that ...
(Date:6/28/2020)... ... June 26, 2020 , ... The ... today announced its strong opposition to the recently introduced bicameral Facial Recognition ... ban on most federal use of nearly all biometric and related image analytics ...
Breaking Biology Technology:
Cached News: