SFVAMC/UCSF researchers develop lead for a new Alzheimer's disease drug - a fragment of a brain grow...( vast chemical libraries for more potent...)

SFVAMC/UCSF researchers develop lead for a new Alzheimer's disease drug - a fragment of a brain growth protein

vast chemical libraries for more potent compounds," he said. These chemical libraries contain thousands of drug-like chemicals that can be searched through computer databases.

"Without our active molecules to serve as guides, it would be quite difficult to effectively search these vast libraries," he said.

Chemicals that closely match the shapes and structures in the NGF fragments will be gathered for further testing in nerve cell cultures. The most potent of these will then be tested in mouse models of Alzheimer's disease, Longo said.

"Our lead compounds will contribute to the long-term goal of creating drugs that prevent the onset and/or slow the progression of Alzheimer's disease," he said.

Most of the results presented by Longo were also published in the September 22 issue of the Journal of Biological Chemistry. Co-authors on the study were Youmei Xie, MD, UCSF/SFVAMC postdoctoral researcher in neurology, Michelle Tisi, BA, lab technician, Tracy Yeo, PhD, UCSF assistant professor of neurology.

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Contact: Kevin Boyd
kboyd@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
7-Nov-2000

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