HOME >> BIOLOGY >> NEWS
Salk Institute and SUGEN scientists map 'human kinome'

La Jolla, Calif.--A California research team has mapped an entire group of human enzymes, providing important information for the development of a new generation of drugs to treat cancer and other diseases. The findings will be published in the Dec. 6 issue of Science.

In the study, the team from the Salk Institute for Biological Studies and the biotechnology company SUGEN created a detailed catalog of the 518 protein kinase genes encoded by the human genome. Protein kinases are among the most important regulators of cell behavior. By chemically adding phosphate groups to other proteins, they control the activity of up to 30 percent of all cellular proteins, and are involved in almost all cellular functions. They are especially important in sending signals between and within cells, and in orchestrating complex functions such as cell division. Overactive kinases are the cause of some types of cancer, and the central role of kinases in controlling cell behavior has led to their being investigated as targets for treatment of a variety of other diseases, including diabetes, osteoporosis, inflammation and occular diseases.

Scientists in academia and pharmaceutical companies have intensively studied the role of kinases in basic biology and in disease for many years, and several drugs targeting kinases are under development. These drugs may offer an alternative treatment to standard chemotherapy for the treatment of specific kinds of cancer. The recently approved anti-cancer drug Gleevec, which is proving successful in treating chronic myeloid leukemia, is the first example of a small molecule kinase inhibitor drug of this sort.

The Human Kinome Project, as the researchers have called the current study, will have broad implications in both the development of new drugs and the understanding of basic cellular biology. Not only does it add over 100 new kinases that were not previously studied, it also classifies and compares all human kinases w
'"/>

Contact: Robert Bradford
bradford@salk.edu
858-453-4100
Salk Institute
5-Dec-2002


Page: 1 2 3

Related biology news :

1. NIH awards $18.2m to The Burnham Institute to develop Center on Proteolytic Pathways
2. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
3. The future of HIV therapeutics is brightening, according to Gladstone Institutes Director
4. Institute for OneWorld Health nominated for the 2004 World Technology Awards
5. UNC researchers awarded $8.65 million from National Institute on Aging
6. Institute for OneWorld Health receives Gates Foundation grant
7. Lupus Research Institute awards $3 million in novel research grants to further new science in lupus
8. Virginia Bioinformatics Institute researcher advances fight against sudden oak death disease
9. Institute for OneWorld Health CEO to speak at BIO on leveraging opportunities for global health
10. Institute for OneWorld Health CEO advocates focus first on developing world markets
11. Institute for Systems Biology, Pacific Northwest National Laboratory announce collaboration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... ... Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 ... but what is the most effective way to complete one? Will the study ...
(Date:7/2/2020)... ... 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , a ... for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology Association ... of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 single ...
(Date:7/1/2020)... Calif. (PRWEB) , ... July 01, 2020 , ... ... on building awareness and solutions for glioblastoma—the most common and aggressive adult brain ... Lisa Haile, JD, PhD. Senior Fellows are charged with supporting the organization’s initiatives ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). ... Specifically, for medical devices, the NMPA has departments dealing with medical device registration (pre-market ...
(Date:7/18/2020)... ... July 16, 2020 , ... Medial EarlySign , a ... prevention of high-burden diseases, and Centric Consulting, a business and technology consulting firm, ... existing data in order to identify and prioritize patients for care. , Combining ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
(Date:7/7/2020)... ... July 06, 2020 , ... R3 International is now offering ... to 200 million stem cells. Depending on the patient's condition, treatment may be offered ... will die having some form of Alzheimers dementia, and the incidence continues to increase ...
Breaking Biology Technology:
Cached News: