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Salmonella uses molecular staples to change structure of infected cells

"While SipA is specific to Salmonella, many bacterial pathogens use their own virulence proteins to manipulate actin in the cytoplasm," Stebbins says. "What we have learned about Salmonella is a first step in a coming molecular understanding of similar processes in many bacteria. This field of study is really coming of age."

Defining how pathogens invade human cells may ultimately aid in the design of novel antibiotics, which is increasingly important given the rise of antibiotic resistance, Stebbins says.


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Contact: Joseph Bonner
bonnerj@rockefeller.edu
212-327-8998
Rockefeller University
25-Sep-2003


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