Salvage Gene Is At The Root Of Many Mutations

A trio of University of Rochester researchers has unexpectedly discovered that most mutations in yeast are caused by the activity of an enzyme that acts to salvage irreparably damaged DNA. The enzyme, REV1, helps a cell evade its own stringent quality control and opens the door to mutations. The findings are reported in the August 22 issue of Nature.

The researchers set out to understand the function of a family of DNA repair enzymes in yeast. When they damaged the yeast's DNA and then studied the yeast's coping mechanisms, they made a startling discovery: Almost all mutations in DNA, ironically, result from the activity of one of the DNA repair enzymes, REV1.

"We really found something that we weren't at all looking for," says David Hinkle, associate professor of biology. "This was a bombshell." Also working on the project, funded by the National Institutes of Health, are postdoctoral fellow John Nelson and Christopher Lawrence, professor of biophysics.

The vast majority of mutations come not from asbestos, pesticides, or other environmental factors, but from normal chemistry that goes on within our bodies. "DNA is not a stainless steel molecule," Lawrence points out. "It is susceptible to damage as a natural part of its existence."

The most common form of DNA damage is sporadic loss of individual molecules of adenine and guanine -- two of the four bases that encode genetic information along a strand of DNA. Such losses result in genetic gaps known as "abasic" sites.

"Formation of these abasic sites," says Hinkle, "is, in fact, one of the most common occurrences in our cells," taking place every day in about 10,000 to 20,000 of the three trillion DNA bases in each of our cells. Uncorrected abasic sit

Contact: Steve Bradt
University of Rochester

Page: 1 2 3

Related biology news :

1. Mutations may yield clues to heartbreaking childhood disease
2. Mutations in the ABCR gene are an overwhelming cause of inherited vision loss
3. Mutations not the only gene defect that leads to cancer
4. Emory University Scientists Demonstrate New Pathway For Genetic Mutations In Everyday Cell Life
5. Genetic Mutations Linked To Rare Metabolic Disease
6. Aspirin Decreases Genetic Mutations Associated With Inherited Colon Cancer
7. New Genetic Mutation Linked To Breast Cancer Risk Poses Less Risk Than Previously Discovered Gene Mutations
8. Frequent Genetic Mutations In Hepatocellular Carcinoma
9. UCSF Researchers Identify Mutations In Gene Causing Hereditary Form Of Childhood Rickets
10. Women Who Smoke While Pregnant Pass Along Genetic Mutations To Their Babies, According To Pitt Researchers
11. Common Mutations Linked To Increased Risk Of Breast Cancer

Post Your Comments:

(Date:6/28/2020)... BASEL, Switzerland (PRWEB) , ... ... ... leading provider of enterprise software solutions for biopharmaceutical R&D, today announced that ... oncology company developing innovative, full-length multispecific antibodies (Multiclonics®), to support their translational ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... monoclonal antibody development services, today announced that the company has received ISO9001:2015 ... the pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... announce the next event in a series of TOPIQ webinars, which will cover ... of webinars was developed in response to social distancing measures that resulted in ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 30, 2020 , ... ... today announced the release of its signature product called Beacon - a ... and other field medical professionals. , Beacon helps MSLs streamline communication ...
(Date:7/18/2020)... ... 17, 2020 , ... dicentra , a leading Contract ... industries, is pleased to announce that Charles Galea has joined its clinical trials ... is an accomplished and results-driven sales executive with over 10 years of expertise ...
(Date:7/7/2020)... ... ... R3 International is now offering stem cell therapy for Alzheimers dementia in ... the patient's condition, treatment may be offered IV, intrathecal or with a combination. , ... dementia, and the incidence continues to increase as individuals live longer. There is no ...
(Date:6/28/2020)... ... 2020 , ... The Indoor Lab, a leading provider of sensor solutions for ... types to ensure cleanliness, distancing and occupancy with its patent pending WipeAway™ technology using ... will provide a health performance index system that scores all aspects of compliance similar ...
Breaking Biology Technology:
Cached News: