HOME >> BIOLOGY >> NEWS
Same gene found to cause mental retardation in children, neurodegenerative condition in older males

HONOLULU, HI Researchers have recently discovered a progressive neurodegenerative condition -- resulting in tremor, balance problems, and dementia -- which may affect as many as one in 3,000 men. This condition has now been associated with the same gene that causes fragile X syndrome, the most common heritable form of mental retardation. Findings of this study are being presented at the American Academy of Neurology Annual Meeting in Honolulu, March 29-April 5, 2003.

Remarkably, the same gene has been found to cause these two different and independent syndromes, affecting different groups of individuals. Fragile X syndrome is a developmental disorder beginning in childhood, while the newly identified neurological syndrome (Fragile X Associated Tremor/Ataxia Syndrome, or FXTAS) affects mainly male carriers who were not affected by fragile X syndrome retardation, and who displayed no symptoms prior to age 50.

"We discovered that FXTAS-affected individuals have numerous inclusions, or spherical particles, in their brain cells," noted study author Paul Hagerman, MD, PhD, professor of Biological Chemistry at the University of California Davis School of Medicine. Through this study, the researchers are determining what is in the inclusions and why they form. "We believe this finding is an important clue as to the cause of the disorder, one that may ultimately help with development of therapies for both the tremor disorder and fragile X syndrome."

Currently, male carriers of the gene do not know they are carriers unless there is an affected grandchild in the family. This is how the researchers have discovered the cases studied to date. Affected individuals have thus far been given other, descriptive diagnoses, such as "atypical Parkinson disease," and have in many cases seen multiple neurologists in their efforts to diagnose their condition.

"We hope that one of the positive outcomes of our investigations will be a greater awareness withi
'"/>

Contact: Marilee Reu
mreu@aan.com
651-695-2789
American Academy of Neurology
2-Apr-2003


Page: 1 2

Related biology news :

1. New signs of life found at the Poles
2. Key cell-death step found
3. European common frog found to use novel mating strategy
4. Byproduct of water-disinfection process found to be highly toxic
5. Genuine stem cells found in skin might treat hair loss, wounds
6. Flame retardants found on supermarket shelves
7. Anti-cancer compound in vegetables found to block late-stage breast-cancer cell growth
8. Genetic clues found for common congenital brain disorder
9. New clues to hereditary blinding disease found
10. Anti-bacterial additive found in Maryland streams
11. Genetic mutation linked to more aggressive breast cancer found more often in African-Americans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... FRANCISCO (PRWEB) , ... February 04, 2019 , ... ... of a new Explorer™ story which provides insights to help individuals understand how ... to decreased cardiovascular wellness. , After individuals eat foods that contain choline ...
(Date:2/2/2019)... ... February 01, 2019 , ... uBiome, ... Testing Laboratories by A2LA, which establishes requirements for medical laboratories to demonstrate competence ... is already CLIA-licensed as well as College of American Pathologists (CAP)-accredited, a designation ...
(Date:1/24/2019)... ... 23, 2019 , ... rHEALTH LLC, an innovative digital health ... the United States Patent and Trademark Office (USPTO) for U.S. Patent Application No. ... This application covers the addition of a length scale to hydrogel microparticles. ...
Breaking Biology News(10 mins):
(Date:1/15/2019)... ... 15, 2019 , ... Personalized treatment plans may extend life expectancy for early-stage ... new study published in the journal Radiology. , Kidney, or renal, tumors are ... surgical procedure in which the tumor and part of the kidney are removed. However, ...
(Date:1/11/2019)... ... 11, 2019 , ... Drawing on over 22 years of software development expertise, ... EST will explore some of the key lessons that have driven customer satisfaction with ... multiple vendors, and find out how to ensure that you continue to be able ...
(Date:1/10/2019)... (PRWEB) , ... January 08, 2019 , ... VGI Medical ... has become a leader in bringing innovation to the market including VerteLoc, CerLoc, SiJoin ... the facet joint by utilizing a unique patented dual geometric design to limit motion ...
(Date:1/7/2019)... ... 07, 2019 , ... Kainos Medicine Inc. today announced that ... code-named "KM-819." KM-819 is an orally active small molecule that is a ... , This Phase 1 randomized, double-blind, placebo-controlled dose-escalation study was to evaluate ...
Breaking Biology Technology:
Cached News: