The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
Science researchers report 'extremely unstable' gene expression in cloned mice

nd kidney, heart, and liver of mice cloned from embryonic stem cells. Unlike normal mice and mice created by in vitro fertilization, the expression of these genes varied widely between placentas and tissues of the clones, the researchers found.

They also discovered that the abnormal expression of one particular gene, called H19, was linked to a chemical alteration in part of the gene called methylation, another epigenetic phenomenon. Methylation, the addition of methyl groups to particular DNA nucleotides, makes the gene harder to transcribe and therefore lowers its expression levels. Degrees of methylation of H19 varied between the clones.

Although most of the mice showed increased birth and placental weights, along with the changes in gene expression, the researchers didn't find any significant correlation between any of the specific variations in gene expression and increased weight. The cumulative action of many abnormally expressed genes may be necessary to produce the overgrowth in clones, say the researchers in their report.

After documenting the changes in gene expression for the clones themselves, the investigators turned their attention to a second question: were these abnormalities produced by the cloning process itself, or did they already exist in the embryonic stem cells used to create the clones?

The scientists found that variation in imprinted gene expression was rampant among the stem cells as well. Wide variation in expression was observed between different embryonic stem cell lines, between individual colonies of cells, or subclones, of each line, and even between individual cells within each colony, surprising the researchers.

This research suggests that extreme variability in gene expression may be the hallmark of embryonic stem cells, noted Jaenisch.

The researchers are interested in finding out whether the epigenetic state of human embryonic stem cells cultured fo
'"/>

Contact: Ginger Pinholster
gpinhols@aaas.org
202-326-6421
American Association for the Advancement of Science
5-Jul-2001


Page: 1 2 3

Related biology news :

1. A long-necked sea predator from China described in Science
2. Brown ecologist garners major National Science Foundation grant
3. Popular Science announces Third Annual Brilliant 10
4. Winner of 2004 EMBO Science Writing Prize announced
5. Study in Science reveals recreational fishing takes big bite of ocean catch
6. New paper in Science introduces revolutionary new paradigm for fishery management
7. Articles on forest fire risks published in BioScience
8. Ralph J. Cicerone nominated to be next National Academy of Sciences president
9. Canine word-learning research published in Science
10. Articles on remote sensing in ecology published in BioScience
11. Fostering Diversity in the Sciences Symposium

Post Your Comments:
(Date:11/4/2009)... Software, Inc., the commercial arm of the Open Mi...enmicroscopy.org ), is proud to announce its coll...y,s exciting new project titled "The Cell: An Imag...ulus grant through the National Institutes of Heal... the American Reinvestment and Recovery Act, to bu...
(Date:11/3/2009)...shed in a recent issue of HortTechnology , scient...ffects of covering orchard floors with reflective ...distribution, orchard temperature, and profitabili...and Solarmate films installed 5 weeks before comme.... The research showed that the use of both films i...
(Date:11/3/2009)...ool of Engineering and Applied Science have for th...oratory the enzyme responsible for producing the b... , The research, published Oct. 23 in the journ...pment of other compounds with similarly beneficial...e is one of the most interesting but least underst...
Breaking Biology News(10 mins):Glencoe Software to Support the ASCB 'Stimulus Grant' to Build Virtual Image Library of the Cell 2Reflective film can boost profits for apple growers 2UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin 2Scientists open doors to diagnosis of emphysema 9456 1Scientists open doors to diagnosis of emphysema 9456 2COMFORCE Corporation to Hold Conference Call to Discuss Second Quarter 2009 Results 53484 1COMFORCE Corporation to Hold Conference Call to Discuss Second Quarter 2009 Results 53484 2International Milk Genomics 26amp 3B Human Health Symposium Speaker Program Announced 13329 1International Milk Genomics 26amp 3B Human Health Symposium Speaker Program Announced 13329 2International Milk Genomics 26amp 3B Human Health Symposium Speaker Program Announced 13329 3
(Date:11/5/2009)... Drug safety specialty firm Bi...rning and Informatics earned the Certified Profess...edential from the American Society for Training an...helle Flewell has more than fifteen years of medic...nce and is responsible for the development of the ...
(Date:11/4/2009)... This webinar, which will be p...ne working in continuous flow chemistry processing...ow cell inline using various meso and micro scale ... over 670 publications has been recognized with se...t recently the 2009 Tetrahedron Prize. , ...
(Date:11/4/2009)... PETERSBURG, Va., Nov. 4 ...ced today that the company plans to introduce the ...ubsidiary, Rock Creek Pharmaceuticals, for worldwi...tiv Health, Inc . (Nasdaq: VTIV). inVentiv Healt...utions for every stage of the product lifecycle, i...
(Date:11/4/2009)... SAN CARLOS, Calif., Nov. 4 /PRNewswire-FirstCall/...orted its financial results for the third quarter ...quarter ended September 30, 2009 improved to $31.0...loss of $37.0 million or $0.40 per share in the th...make improvements to its operating efficiencies as...
Breaking Biology Technology:BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 2BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 3BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 4Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 2Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 2Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 4Nektar Therapeutics Reports Third Quarter 2009 Financial Results 2Nektar Therapeutics Reports Third Quarter 2009 Financial Results 3Nektar Therapeutics Reports Third Quarter 2009 Financial Results 4Nektar Therapeutics Reports Third Quarter 2009 Financial Results 5Nektar Therapeutics Reports Third Quarter 2009 Financial Results 6Nektar Therapeutics Reports Third Quarter 2009 Financial Results 7Nektar Therapeutics Reports Third Quarter 2009 Financial Results 8Nektar Therapeutics Reports Third Quarter 2009 Financial Results 9Nektar Therapeutics Reports Third Quarter 2009 Financial Results 10
Other News:
.... Wheeze associated with prenatal tobacco smoke ex...: 307-12 ... Young children may be at increased ri...ing pregnancy, finds research in the Archives of D...f the effects of exposure to environmental tobacco...
....Findings suggest replacing refined grains with wh...- Higher intakes of whole grain foods are associat...independent of known cardiovascular disease (CVD) ...mber 27 issue of The Journal of the American Medic...
....Now that a map of the human genome is nearly comp...ing the form and function of the proteins our gene...t, the Stanford Synchrotron Radiation Laboratory (...ipate in determining the three-dimensional structu...
In a large-scale study of middle-aged men spanning eight years, Hu and colleagues tracked the food consumption of 44,875 men and identified two overall dietary patterns which they labeled as either "p
Increased consumption of whole grain foods associated with decreased risk of stroke 2Stanford Synchrotron Radiation Lab receives $6 million grant to decipher protein structures 2Dietary patterns predict heart attack risk in middle-aged men 2
... 6, 2004) -- Mechanical loading through exercise ...unced during skeletal growth and development, acco...tment of Orthopaedic Surgery and director of ortho...f Medicine, Indianapolis.......Exercise that puts ...
.... - The pathogen responsible for a precooked chick... in ready-to-eat meats, thanks to a new biosensor ....A team of food scientists has developed a sensor ...steria monocytogenes in less than 24 hours at conc...
...g as three months after their prostate cancer diag...orse than those who have treatment sooner. That i...Chase Cancer Center presented today at the 46th An...ic Radiology and Oncology in Atlanta, Ga...."The t...
... Royal Swedish Academy of Sciences announced today...rine Biological Laboratory in Woods Hole, Massachu...ry for "the discovery of ubiquitin-mediated protei...emistry at the Technion-Israel Institute of Techno...
Running not swimming or biking is best kind of loading exercise for childrens bone growth 2Running not swimming or biking is best kind of loading exercise for childrens bone growth 3New biosensor rapidly detects deadly foodborne pathogen 2New biosensor rapidly detects deadly foodborne pathogen 3New biosensor rapidly detects deadly foodborne pathogen 4Does a time delay between prostate cancer diagnosis and start of radiation treatment matter? 2Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry 2Marine Biological Laboratory summer investigator wins Nobel Prize in Chemistry 3